Literature DB >> 30221203

Event segmentation protects emotional memories from competing experiences encoded close in time.

Joseph E Dunsmoor1, Marijn C W Kroes2, Caroline M Moscatelli3, Michael D Evans3, Lila Davachi4, Elizabeth A Phelps3,5,6.   

Abstract

Fear memories are characterized by their permanence and a fierce resistance to unlearning by new experiences. We considered whether this durability involves a process of memory segmentation that separates competing experiences. To address this question, we used an emotional learning task designed to measure recognition memory for category exemplars encoded during competing experiences of fear-conditioning and extinction. Here we show that people recognized more fear-conditioned exemplars encoded during conditioning than conceptually related exemplars encoded immediately after a perceptual event boundary separating conditioning from extinction. Selective episodic memory depended on a period of consolidation, an explicit break between competing experiences, and was unrelated to within-session arousal or the explicit realization of a transition from conditioning to extinction. Collectively, these findings suggest that event boundaries guide selective consolidation to prioritize emotional information in memory-at the expense of related but conflicting information experienced shortly thereafter. We put forward a model whereby event boundaries bifurcate related memory traces for incompatible experiences. This stands in contrast to a mechanism that integrates related experiences for adaptive generalization123, and reveals a potentially distinct organization by which competing memories are adaptively segmented to select and protect nascent fear memories from immediate sources of interference.

Entities:  

Year:  2018        PMID: 30221203      PMCID: PMC6136428          DOI: 10.1038/s41562-018-0317-4

Source DB:  PubMed          Journal:  Nat Hum Behav        ISSN: 2397-3374


  54 in total

1.  Post-training injections of catecholaminergic drugs do not modulate fear conditioning in rats and mice.

Authors:  H J Lee; S Y Berger; O Stiedl; J Spiess; J J Kim
Journal:  Neurosci Lett       Date:  2001-05-04       Impact factor: 3.046

Review 2.  Context, ambiguity, and unlearning: sources of relapse after behavioral extinction.

Authors:  Mark E Bouton
Journal:  Biol Psychiatry       Date:  2002-11-15       Impact factor: 13.382

3.  Similarity breeds proximity: pattern similarity within and across contexts is related to later mnemonic judgments of temporal proximity.

Authors:  Youssef Ezzyat; Lila Davachi
Journal:  Neuron       Date:  2014-03-05       Impact factor: 17.173

4.  A model for Pavlovian learning: variations in the effectiveness of conditioned but not of unconditioned stimuli.

Authors:  J M Pearce; G Hall
Journal:  Psychol Rev       Date:  1980-11       Impact factor: 8.934

5.  Consolidation in human motor memory.

Authors:  T Brashers-Krug; R Shadmehr; E Bizzi
Journal:  Nature       Date:  1996-07-18       Impact factor: 49.962

6.  The computational nature of memory modification.

Authors:  Samuel J Gershman; Marie-H Monfils; Kenneth A Norman; Yael Niv
Journal:  Elife       Date:  2017-03-15       Impact factor: 8.140

Review 7.  Dopamine and adaptive memory.

Authors:  Daphna Shohamy; R Alison Adcock
Journal:  Trends Cogn Sci       Date:  2010-09-09       Impact factor: 20.229

8.  Emotional learning selectively and retroactively strengthens memories for related events.

Authors:  Joseph E Dunsmoor; Vishnu P Murty; Lila Davachi; Elizabeth A Phelps
Journal:  Nature       Date:  2015-01-21       Impact factor: 49.962

9.  Delayed extinction attenuates conditioned fear renewal and spontaneous recovery in humans.

Authors:  Nicole C Huff; Jose Alba Hernandez; Nineequa Q Blanding; Kevin S LaBar
Journal:  Behav Neurosci       Date:  2009-08       Impact factor: 1.912

10.  Gating of fear in prelimbic cortex by hippocampal and amygdala inputs.

Authors:  Francisco Sotres-Bayon; Demetrio Sierra-Mercado; Enmanuelle Pardilla-Delgado; Gregory J Quirk
Journal:  Neuron       Date:  2012-11-21       Impact factor: 17.173

View more
  14 in total

1.  Episodic memory and Pavlovian conditioning: ships passing in the night.

Authors:  Joseph E Dunsmoor; Marijn C W Kroes
Journal:  Curr Opin Behav Sci       Date:  2018-10-11

2.  Role of Human Ventromedial Prefrontal Cortex in Learning and Recall of Enhanced Extinction.

Authors:  Joseph E Dunsmoor; Marijn C W Kroes; Jian Li; Nathaniel D Daw; Helen B Simpson; Elizabeth A Phelps
Journal:  J Neurosci       Date:  2019-02-19       Impact factor: 6.167

3.  Neural reinstatement reveals divided organization of fear and extinction memories in the human brain.

Authors:  Augustin C Hennings; Mason McClay; Michael R Drew; Jarrod A Lewis-Peacock; Joseph E Dunsmoor
Journal:  Curr Biol       Date:  2021-11-22       Impact factor: 10.834

4.  Contextual reinstatement promotes extinction generalization in healthy adults but not PTSD.

Authors:  Augustin C Hennings; Mason McClay; Jarrod A Lewis-Peacock; Joseph E Dunsmoor
Journal:  Neuropsychologia       Date:  2020-07-29       Impact factor: 3.139

5.  Behavioral and neural processes in counterconditioning: Past and future directions.

Authors:  Nicole E Keller; Augustin C Hennings; Joseph E Dunsmoor
Journal:  Behav Res Ther       Date:  2019-12-12

6.  Active suppression prevents the return of threat memory in humans.

Authors:  Ye Wang; Zijian Zhu; Jingchu Hu; Daniela Schiller; Jian Li
Journal:  Commun Biol       Date:  2021-05-21

Review 7.  Laboratory models of post-traumatic stress disorder: The elusive bridge to translation.

Authors:  Joseph E Dunsmoor; Josh M Cisler; Gregory A Fonzo; Suzannah K Creech; Charles B Nemeroff
Journal:  Neuron       Date:  2022-03-23       Impact factor: 18.688

8.  Event boundaries do not cause the immediate extinction deficit after Pavlovian fear conditioning in rats.

Authors:  Michael S Totty; Martin R Payne; Stephen Maren
Journal:  Sci Rep       Date:  2019-07-01       Impact factor: 4.379

9.  Thought suppression inhibits the generalization of fear extinction.

Authors:  Augustin C Hennings; Sophia A Bibb; Jarrod A Lewis-Peacock; Joseph E Dunsmoor
Journal:  Behav Brain Res       Date:  2020-10-11       Impact factor: 3.332

10.  The limited reach of surprise: Evidence against effects of surprise on memory for preceding elements of an event.

Authors:  Aya Ben-Yakov; Verity Smith; Richard Henson
Journal:  Psychon Bull Rev       Date:  2021-06-25
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.