Literature DB >> 30177374

X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.

Pierre Montay-Gruel1, Audrey Bouchet2, Maud Jaccard3, David Patin3, Raphael Serduc4, Warren Aim2, Kristoffer Petersson5, Benoit Petit1, Claude Bailat3, Jean Bourhis1, Elke Bräuer-Krisch6, Marie-Catherine Vozenin7.   

Abstract

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
Copyright © 2018. Published by Elsevier B.V.

Entities:  

Keywords:  Cognitive impairment; Radiation-induced brain injury; Synchrotron radiation; Ultra-high dose-rate X-ray radiation

Mesh：

Year:  2018        PMID： 30177374     DOI： 10.1016/j.radonc.2018.08.016

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN： 0167-8140            Impact factor:   6.280


  48 in total

1.  An ionizing radiation acoustic imaging (iRAI) technique for real-time dosimetric measurements for FLASH radiotherapy.

Authors:  Ibrahim Oraiqat; Wei Zhang; Dale Litzenberg; Kwok Lam; Noora Ba Sunbul; Jean Moran; Kyle Cuneo; Paul Carson; Xueding Wang; Issam El Naqa
Journal:  Med Phys       Date:  2020-08-16       Impact factor: 4.071

2.  Biological effects in normal cells exposed to FLASH dose rate protons.

Authors:  Manuela Buonanno; Veljko Grilj; David J Brenner
Journal:  Radiother Oncol       Date:  2019-03-05       Impact factor: 6.280

3.  Maintenance of Tight Junction Integrity in the Absence of Vascular Dilation in the Brain of Mice Exposed to Ultra-High-Dose-Rate FLASH Irradiation.

Authors:  Barrett D Allen; Munjal M Acharya; Pierre Montay-Gruel; Patrik Goncalves Jorge; Claude Bailat; Benoît Petit; Marie-Catherine Vozenin; Charles Limoli
Journal:  Radiat Res       Date:  2020-12-01       Impact factor: 2.841

Review 4.  Biological Benefits of Ultra-high Dose Rate FLASH Radiotherapy: Sleeping Beauty Awoken.

Authors:  M-C Vozenin; J H Hendry; C L Limoli
Journal:  Clin Oncol (R Coll Radiol)       Date:  2019-04-19       Impact factor: 4.126

5.  A simulation study of ionizing radiation acoustic imaging (iRAI) as a real-time dosimetric technique for ultra-high dose rate radiotherapy (UHDR-RT).

Authors:  Noora H Ba Sunbul; Wei Zhang; Ibrahim Oraiqat; Dale W Litzenberg; Kwok L Lam; Kyle Cuneo; Jean M Moran; Paul L Carson; Xueding Wang; Shaun D Clarke; Martha M Matuszak; Sara A Pozzi; Issam El Naqa
Journal:  Med Phys       Date:  2021-09-08       Impact factor: 4.071

Review 6.  Organoids as Complex In Vitro Models for Studying Radiation-Induced Cell Recruitment.

Authors:  Benjamin C Hacker; Marjan Rafat
Journal:  Cell Mol Bioeng       Date:  2020-06-15       Impact factor: 2.321

7.  Ultra-High-Dose-Rate FLASH Irradiation Limits Reactive Gliosis in the Brain.

Authors:  Pierre Montay-Gruel; Mineh Markarian; Barrett D Allen; Jabra D Baddour; Erich Giedzinski; Patrik Goncalves Jorge; Benoît Petit; Claude Bailat; Marie-Catherine Vozenin; Charles Limoli; Munjal M Acharya
Journal:  Radiat Res       Date:  2020-12-01       Impact factor: 2.841

Review 8.  All for one, though not one for all: team players in normal tissue radiobiology.

Authors:  Marjan Boerma; Catherine M Davis; Isabel L Jackson; Dörthe Schaue; Jacqueline P Williams
Journal:  Int J Radiat Biol       Date:  2021-07-01       Impact factor: 2.694

9.  Modeling the effect of oxygen on the chemical stage of water radiolysis using GPU-based microscopic Monte Carlo simulations, with an application in FLASH radiotherapy.

Authors:  Youfang Lai; Xun Jia; Yujie Chi
Journal:  Phys Med Biol       Date:  2021-01-26       Impact factor: 3.609

10.  Evaluating the Reproducibility of Mouse Anatomy under Rotation in a Custom Immobilization Device for Conformal FLASH Radiotherapy.

Authors:  Ryan B Ko; Luis A Soto; Rie von Eyben; Stavros Melemenidis; Erinn B Rankin; Peter G Maxim; Edward E Graves; Billy W Loo
Journal:  Radiat Res       Date:  2020-12-01       Impact factor: 2.841
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