Zhichao Wu1,2,3, Denis S D Weng1, Abinaya Thenappan1, Rashmi Rajshekhar1, Robert Ritch4, Donald C Hood1,5. 1. Department of Psychology, Columbia University, New York, NY, USA. 2. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia. 3. Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Australia. 4. Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA. 5. Department of Ophthalmology, Columbia University, New York, NY, USA.
Abstract
PURPOSE: Our purpose was to compare the effectiveness of detecting progressive retinal nerve fiber layer (RNFL) thickness changes using widefield scans compared to circumpapillary circle scans derived from optic disc volume scans when using a manual region-of-interest (ROI) approach. METHODS: In a prospective observational study, a total of 125 eyes diagnosed clinically with glaucoma or suspected glaucoma that had both widefield (12 × 9 mm) and optic disc (6 × 6 mm) scans obtained at least one year apart were included. Changes in the RNFL thickness between the two visits were evaluated within region(s) of observed or suspected glaucomatous damage, which were manually outlined after reviewing key features from each scan on the second visit (described as a manual ROI approach). Within ROI(s), changes in the widefield and circumpapillary RNFL thickness (wfRNFLROI and cpRNFLROI), as well as in the global circumpapillary RNFL thickness (cpRNFLG), were determined. The performance of these three methods for detecting progressive changes was compared using longitudinal signal-to-noise ratios (SNRs), whereby the rate of change determined by each method was normalized by individualized estimates of measurement variability and age-related change. RESULTS: On average, the longitudinal SNRs for the wfRNFLROI, cpRNFLROI, and cpRNFLG methods were -0.57, -0.38, and -0.23 y-1, respectively, being significantly more negative for the wfRNFLROI than the latter two methods (P ≤ 0.009). CONCLUSIONS: Progressive RNFL thickness changes were more effectively detected on widefield optical coherence tomography (OCT) scans using a manual ROI approach compared to conventional derived circumpapillary circle scans. TRANSLATIONAL RELEVANCE: Widefield OCT scans show promise for improving the detection of glaucomatous progression.
PURPOSE: Our purpose was to compare the effectiveness of detecting progressive retinal nerve fiber layer (RNFL) thickness changes using widefield scans compared to circumpapillary circle scans derived from optic disc volume scans when using a manual region-of-interest (ROI) approach. METHODS: In a prospective observational study, a total of 125 eyes diagnosed clinically with glaucoma or suspected glaucoma that had both widefield (12 × 9 mm) and optic disc (6 × 6 mm) scans obtained at least one year apart were included. Changes in the RNFL thickness between the two visits were evaluated within region(s) of observed or suspected glaucomatous damage, which were manually outlined after reviewing key features from each scan on the second visit (described as a manual ROI approach). Within ROI(s), changes in the widefield and circumpapillary RNFL thickness (wfRNFLROI and cpRNFLROI), as well as in the global circumpapillary RNFL thickness (cpRNFLG), were determined. The performance of these three methods for detecting progressive changes was compared using longitudinal signal-to-noise ratios (SNRs), whereby the rate of change determined by each method was normalized by individualized estimates of measurement variability and age-related change. RESULTS: On average, the longitudinal SNRs for the wfRNFLROI, cpRNFLROI, and cpRNFLG methods were -0.57, -0.38, and -0.23 y-1, respectively, being significantly more negative for the wfRNFLROI than the latter two methods (P ≤ 0.009). CONCLUSIONS: Progressive RNFL thickness changes were more effectively detected on widefield optical coherence tomography (OCT) scans using a manual ROI approach compared to conventional derived circumpapillary circle scans. TRANSLATIONAL RELEVANCE: Widefield OCT scans show promise for improving the detection of glaucomatous progression.
Authors: Abinaya Thenappan; Carlos Gustavo De Moraes; Diane L Wang; Daiyan Xin; Ravivarn Jarukasetphon; Robert Ritch; Donald C Hood Journal: J Glaucoma Date: 2017-05 Impact factor: 2.503
Authors: Donald C Hood; Brad Fortune; Maria A Mavrommatis; Juan Reynaud; Rithambara Ramachandran; Robert Ritch; Richard B Rosen; Hassan Muhammad; Alfredo Dubra; Toco Y P Chui Journal: Invest Ophthalmol Vis Sci Date: 2015-10 Impact factor: 4.799
Authors: Atsuya Miki; Felipe A Medeiros; Robert N Weinreb; Sonia Jain; Feng He; Lucie Sharpsten; Naira Khachatryan; Na'ama Hammel; Jeffrey M Liebmann; Christopher A Girkin; Pamela A Sample; Linda M Zangwill Journal: Ophthalmology Date: 2014-03-13 Impact factor: 12.079
Authors: Bingyao Tan; Jacqueline Chua; Thiyagrajan Harish; Amanda Lau; Alfred Tau Liang Gan; Yar Li Tan; Damon W K Wong; Rachel Shujuan Chong; Marcus Ang; Rahat Husain; Leopold Schmetterer Journal: Br J Ophthalmol Date: 2019-10-04 Impact factor: 4.638