Donald C Hood1, Brad Fortune2, Maria A Mavrommatis3, Juan Reynaud2, Rithambara Ramachandran3, Robert Ritch4, Richard B Rosen4, Hassan Muhammad3, Alfredo Dubra5, Toco Y P Chui4. 1. Departments of Psychology and Ophthalmology Columbia University, New York, New York, United States. 2. Legacy Health, Legacy Research Institute, Portland, Oregon, United States. 3. Department of Psychology, Columbia University, New York, New York, United States. 4. Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States. 5. Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
Abstract
PURPOSE: High-resolution images of glaucomatous damage to the retinal nerve fiber layer (RNFL) were obtained with an adaptive optics-scanning light ophthalmoscope (AO-SLO) and used as a basis for comparisons between en face slab images and thickness maps derived from optical coherence tomography (OCT) scans. METHODS: Wide-field (9 × 12 mm) cube scans were obtained with swept-source OCT (DRI-OCT) from six eyes of six patients. All eyes had a deep defect near fixation as seen on a 10-2 visual field test. Optical coherence tomography en face images, based on the average reflectance intensity, were generated (ATL 3D-Suite) from 52-μm slabs just below the vitreal border of the inner limiting membrane. The RNFL thickness maps were generated from the same OCT data. Both were compared with the AO-SLO peripapillary images that were previously obtained. RESULTS: On AO-SLO images, three eyes showed small regions of preserved and/or missing RNFL bundles within the affected region. Details in these regions were seen on the OCT en face images but not on the RNFL thickness maps. In addition, in the healthier hemi-retinas of two eyes, there were darker, arcuate-shaped regions on en face images that corresponded to abnormalities seen on AO-SLO. These were not seen on RNFL thickness maps. CONCLUSIONS: Details of local glaucomatous damage, missing or easily overlooked on traditional OCT RNFL thickness analysis used in clinical OCT reports, were seen on OCT en face images based on the average reflectance intensity. While more work is needed, it is likely that en face slab imaging has a role in the clinical management of glaucoma.
PURPOSE: High-resolution images of glaucomatous damage to the retinal nerve fiber layer (RNFL) were obtained with an adaptive optics-scanning light ophthalmoscope (AO-SLO) and used as a basis for comparisons between en face slab images and thickness maps derived from optical coherence tomography (OCT) scans. METHODS: Wide-field (9 × 12 mm) cube scans were obtained with swept-source OCT (DRI-OCT) from six eyes of six patients. All eyes had a deep defect near fixation as seen on a 10-2 visual field test. Optical coherence tomography en face images, based on the average reflectance intensity, were generated (ATL 3D-Suite) from 52-μm slabs just below the vitreal border of the inner limiting membrane. The RNFL thickness maps were generated from the same OCT data. Both were compared with the AO-SLO peripapillary images that were previously obtained. RESULTS: On AO-SLO images, three eyes showed small regions of preserved and/or missing RNFL bundles within the affected region. Details in these regions were seen on the OCT en face images but not on the RNFL thickness maps. In addition, in the healthier hemi-retinas of two eyes, there were darker, arcuate-shaped regions on en face images that corresponded to abnormalities seen on AO-SLO. These were not seen on RNFL thickness maps. CONCLUSIONS: Details of local glaucomatous damage, missing or easily overlooked on traditional OCT RNFL thickness analysis used in clinical OCT reports, were seen on OCT en face images based on the average reflectance intensity. While more work is needed, it is likely that en face slab imaging has a role in the clinical management of glaucoma.
Authors: Josine van der Schoot; Koenraad A Vermeer; Johannes F de Boer; Hans G Lemij Journal: Invest Ophthalmol Vis Sci Date: 2012-04-30 Impact factor: 4.799
Authors: Koenraad A Vermeer; Josine van der Schoot; Hans G Lemij; Johannes F de Boer Journal: Invest Ophthalmol Vis Sci Date: 2012-09-12 Impact factor: 4.799
Authors: Brad Fortune; Claude F Burgoyne; Grant A Cull; Juan Reynaud; Lin Wang Journal: Invest Ophthalmol Vis Sci Date: 2012-06-22 Impact factor: 4.799
Authors: Donald C Hood; Monica F Chen; Dongwon Lee; Benjamin Epstein; Paula Alhadeff; Richard B Rosen; Robert Ritch; Alfredo Dubra; Toco Y P Chui Journal: Transl Vis Sci Technol Date: 2015-04-10 Impact factor: 3.283
Authors: Maria A Mavrommatis; Nicole De Cuir; Juan Reynaud; Carlos G De Moraes; Daiyan Xin; Rashmi Rajshekhar; Jeffrey M Liebmann; Robert Ritch; Brad Fortune; Donald C Hood Journal: J Glaucoma Date: 2019-03 Impact factor: 2.503
Authors: Hassan Muhammad; Thomas J Fuchs; Nicole De Cuir; Carlos G De Moraes; Dana M Blumberg; Jeffrey M Liebmann; Robert Ritch; Donald C Hood Journal: J Glaucoma Date: 2017-12 Impact factor: 2.503
Authors: Donald C Hood; Daiyan Xin; Diane Wang; Ravivarn Jarukasetphon; Ravivarn Jarukatsetphorn; Rithu Ramachandran; Lola M Grillo; Carlos G De Moraes; Robert Ritch Journal: JAMA Ophthalmol Date: 2015-12 Impact factor: 7.389
Authors: Hongli Yang; Haomin Luo; Christy Hardin; Yaxing Wang; Jin Wook Jeoung; Cindy Albert; Jayme R Vianna; Glen P Sharpe; Juan Reynaud; Shaban Demirel; Steven L Mansberger; Brad Fortune; Marcelo Nicolela; Stuart K Gardiner; Balwantray C Chauhan; Claude F Burgoyne Journal: Am J Ophthalmol Date: 2019-12-30 Impact factor: 5.258
Authors: Zhichao Wu; Abinaya Thenappan; Denis S D Weng; Robert Ritch; Donald C Hood Journal: Transl Vis Sci Technol Date: 2018-02-28 Impact factor: 3.283
Authors: Zhichao Wu; Denis S D Weng; Abinaya Thenappan; Rashmi Rajshekhar; Robert Ritch; Donald C Hood Journal: Transl Vis Sci Technol Date: 2018-06-04 Impact factor: 3.283
Authors: Zhichao Wu; Denis S D Weng; Abinaya Thenappan; Robert Ritch; Donald C Hood Journal: Transl Vis Sci Technol Date: 2018-03-29 Impact factor: 3.283