| Literature DB >> 29795125 |
Barbara Uszczynska-Ratajczak1, Julien Lagarde2,3, Adam Frankish4, Roderic Guigó2,3, Rory Johnson5,6.
Abstract
Gene maps, or annotations, enable us to navigate the functional landscape of our genome. They are a resource upon which virtually all studies depend, from single-gene to genome-wide scales and from basic molecular biology to medical genetics. Yet present-day annotations suffer from trade-offs between quality and size, with serious but often unappreciated consequences for downstream studies. This is particularly true for long non-coding RNAs (lncRNAs), which are poorly characterized compared to protein-coding genes. Long-read sequencing technologies promise to improve current annotations, paving the way towards a complete annotation of lncRNAs expressed throughout a human lifetime.Entities:
Mesh：
Substances：
Year: 2018 PMID： 29795125 PMCID： PMC6451964 DOI： 10.1038/s41576-018-0017-y
Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242