Literature DB >> 31350901

An expanded landscape of human long noncoding RNA.

Shuai Jiang1, Si-Jin Cheng1, Li-Chen Ren1, Qian Wang1, Yu-Jian Kang1, Yang Ding1, Mei Hou1, Xiao-Xu Yang1, Yuan Lin1, Nan Liang1, Ge Gao1.   

Abstract

Long noncoding RNAs (lncRNAs) are emerging as key regulators of multiple essential biological processes involved in physiology and pathology. By analyzing the largest compendium of 14,166 samples from normal and tumor tissues, we significantly expand the landscape of human long noncoding RNA with a high-quality atlas: RefLnc (Reference catalog of LncRNA). Powered by comprehensive annotation across multiple sources, RefLnc helps to pinpoint 275 novel intergenic lncRNAs correlated with sex, age or race as well as 369 novel ones associated with patient survival, clinical stage, tumor metastasis or recurrence. Integrated in a user-friendly online portal, the expanded catalog of human lncRNAs provides a valuable resource for investigating lncRNA function in both human biology and cancer development.
© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

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Year:  2019        PMID： 31350901     DOI： 10.1093/nar/gkz621

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  84 in total

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Journal:  Cancer Cell       Date:  2015-10-12       Impact factor: 31.743

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Authors:  Matthew K Iyer; Yashar S Niknafs; Rohit Malik; Udit Singhal; Anirban Sahu; Yasuyuki Hosono; Terrence R Barrette; John R Prensner; Joseph R Evans; Shuang Zhao; Anton Poliakov; Xuhong Cao; Saravana M Dhanasekaran; Yi-Mi Wu; Dan R Robinson; David G Beer; Felix Y Feng; Hariharan K Iyer; Arul M Chinnaiyan
Journal:  Nat Genet       Date:  2015-01-19       Impact factor: 38.330

5.  The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.

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  38 in total

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8.  Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease.

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