Literature DB >> 33725348

Multifaceted Roles of Long Non-coding RNAs in Head and Neck Cancer.

Leslie Duncan1,2, Chloe Shay3, Yong Teng4,5.   

Abstract

The majority of RNA transcripts are non-coding RNA (ncRNA) transcripts with lengths exceeding 200 nucleotides that are not translated into protein. Unlike microRNAs (miRNAs), long ncRNAs (lncRNAs) are not confined to a single mechanism of action but have a large and diverse role in biological processes as they can function as transcription regulators, decoys, scaffolds, and enhancer RNAs. Currently, many lncRNA molecules are under investigation for their role in tumorigenesis, metastasis, and prognosis in different types of cancer. This review not only summarizes the characteristics and functions of lncRNAs but also discusses the therapeutic implications and applications of lncRNAs with roles associated with head and neck cancer. Our aim is to pinpoint the potential way to perturb specific lncRNAs for future therapeutic use.

Entities:  

Keywords:  Head and neck cancer; Roles and functions; lncRNA

Mesh：

Substances：

Year:  2021        PMID： 33725348     DOI： 10.1007/978-3-030-55035-6_7

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  49 in total

Review 1.  Evolution and functions of long noncoding RNAs.

Authors:  Chris P Ponting; Peter L Oliver; Wolf Reik
Journal:  Cell       Date:  2009-02-20       Impact factor: 41.582

Review 2.  Molecular mechanisms of long noncoding RNAs.

Authors:  Kevin C Wang; Howard Y Chang
Journal:  Mol Cell       Date:  2011-09-16       Impact factor: 17.970

3.  Discovery and annotation of long noncoding RNAs.

Authors:  John S Mattick; John L Rinn
Journal:  Nat Struct Mol Biol       Date:  2015-01       Impact factor: 15.369

4.  ["Di-Lok" tray in construction of bridgework].

Authors:  H Wupper
Journal:  Dent Labor (Munch)       Date:  1969-06

5.  An atlas of human long non-coding RNAs with accurate 5' ends.

Authors:  Chung-Chau Hon; Jordan A Ramilowski; Jayson Harshbarger; Nicolas Bertin; Owen J L Rackham; Julian Gough; Elena Denisenko; Sebastian Schmeier; Thomas M Poulsen; Jessica Severin; Marina Lizio; Hideya Kawaji; Takeya Kasukawa; Masayoshi Itoh; A Maxwell Burroughs; Shohei Noma; Sarah Djebali; Tanvir Alam; Yulia A Medvedeva; Alison C Testa; Leonard Lipovich; Chi-Wai Yip; Imad Abugessaisa; Mickaël Mendez; Akira Hasegawa; Dave Tang; Timo Lassmann; Peter Heutink; Magda Babina; Christine A Wells; Soichi Kojima; Yukio Nakamura; Harukazu Suzuki; Carsten O Daub; Michiel J L de Hoon; Erik Arner; Yoshihide Hayashizaki; Piero Carninci; Alistair R R Forrest
Journal:  Nature       Date:  2017-03-01       Impact factor: 49.962

Review 6.  Modular regulatory principles of large non-coding RNAs.

Authors:  Mitchell Guttman; John L Rinn
Journal:  Nature       Date:  2012-02-15       Impact factor: 49.962

7.  Circulating Long Noncoding RNAs as Biomarkers for Predicting Head and Neck Squamous Cell Carcinoma.

Authors:  Yao Yao; Xinyuan Chen; Shuai Lu; Chao Zhou; Guolong Xu; Zhongyi Yan; Jianrong Yang; Tonghua Yu; Wei Chen; Yichun Qian; Shounian Ding; Junwei Tang; Yun Chen; Yuan Zhang
Journal:  Cell Physiol Biochem       Date:  2018-10-24

8.  The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.

Authors:  Thomas Derrien; Rory Johnson; Giovanni Bussotti; Andrea Tanzer; Sarah Djebali; Hagen Tilgner; Gregory Guernec; David Martin; Angelika Merkel; David G Knowles; Julien Lagarde; Lavanya Veeravalli; Xiaoan Ruan; Yijun Ruan; Timo Lassmann; Piero Carninci; James B Brown; Leonard Lipovich; Jose M Gonzalez; Mark Thomas; Carrie A Davis; Ramin Shiekhattar; Thomas R Gingeras; Tim J Hubbard; Cedric Notredame; Jennifer Harrow; Roderic Guigó
Journal:  Genome Res       Date:  2012-09       Impact factor: 9.043

9.  lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs.

Authors:  Xiu Cheng Quek; Daniel W Thomson; Jesper L V Maag; Nenad Bartonicek; Bethany Signal; Michael B Clark; Brian S Gloss; Marcel E Dinger
Journal:  Nucleic Acids Res       Date:  2014-10-20       Impact factor: 16.971

10.  LncRNADisease: a database for long-non-coding RNA-associated diseases.

Authors:  Geng Chen; Ziyun Wang; Dongqing Wang; Chengxiang Qiu; Mingxi Liu; Xing Chen; Qipeng Zhang; Guiying Yan; Qinghua Cui
Journal:  Nucleic Acids Res       Date:  2012-11-21       Impact factor: 16.971
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