Literature DB >> 29705208

Basic experiments in 2H static NMR for the characterization of protein side-chain dynamics.

Liliya Vugmeyster1, Dmitry Ostrovsky2.   

Abstract

The focus of this review is the basic methodology for applications of static deuteron NMR for studies of dynamics in the side chains of proteins. We review experimental approaches for the measurements of static line shapes and relaxation rates as well as signal enhancement strategies using the multiple echo acquisition scheme. Further, we describe computational strategies for modeling jump and diffusive motions underlying experimental data. Applications are chosen from studies of amyloid fibrils comprising the amyloid-β protein.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Deuterium; Motions; Side-chains dynamics; Solid-state NMR; Static 2H NMR

Mesh：

Substances：

Year:  2018        PMID： 29705208      PMCID： PMC6133770          DOI： 10.1016/j.ymeth.2018.04.030

Source DB:  PubMed          Journal:  Methods        ISSN： 1046-2023            Impact factor:   3.608


  34 in total

1.  Finite pulse width artifact suppression in spin-1 quadrupolar echo spectra by phase cycling.

Authors:  E S Mananga; Y S Rumala; G S Boutis
Journal:  J Magn Reson       Date:  2006-06-19       Impact factor: 2.229

2.  NMR studies of localized water and protein backbone dynamics in mechanically strained elastin.

Authors:  Cheng Sun; Odingo Mitchell; Jiaxin Huang; Gregory S Boutis
Journal:  J Phys Chem B       Date:  2011-11-07       Impact factor: 2.991

3.  Protein dynamics in the solid state from 2H NMR line shape analysis: a consistent perspective.

Authors:  Eva Meirovitch; Zhichun Liang; Jack H Freed
Journal:  J Phys Chem B       Date:  2015-02-03       Impact factor: 2.991

4.  Solvent-Driven Dynamical Crossover in the Phenylalanine Side-Chain from the Hydrophobic Core of Amyloid Fibrils Detected by 2H NMR Relaxation.

Authors:  Liliya Vugmeyster; Dmitry Ostrovsky; Gina L Hoatson; Wei Qiang; Isaac B Falconer
Journal:  J Phys Chem B       Date:  2017-07-21       Impact factor: 2.991

5.  Conformation of amino acid side-chains in proteins.

Authors:  J Janin; S Wodak
Journal:  J Mol Biol       Date:  1978-11-05       Impact factor: 5.469

6.  Methyl group rotation, 1H spin-lattice relaxation in an organic solid, and the analysis of nonexponential relaxation.

Authors:  Peter A Beckmann; Evan Schneider
Journal:  J Chem Phys       Date:  2012-02-07       Impact factor: 3.488

7.  Nuclear magnetic resonance studies of amino acids and proteins. Deuterium nuclear magnetic resonance relaxation of deuteriomethyl-labeled amino acids in crystals and in Halobacterium halobium and Escherichia coli cell membranes.

Authors:  M A Keniry; A Kintanar; R L Smith; H S Gutowsky; E Oldfield
Journal:  Biochemistry       Date:  1984-01-17       Impact factor: 3.162

8.  Dynamics of Hydrophobic Core Phenylalanine Residues Probed by Solid-State Deuteron NMR.

Authors:  Liliya Vugmeyster; Dmitry Ostrovsky; Toni Villafranca; Janelle Sharp; Wei Xu; Andrew S Lipton; Gina L Hoatson; Robert L Vold
Journal:  J Phys Chem B       Date:  2015-11-12       Impact factor: 2.991

9.  Glassy dynamics of protein methyl groups revealed by deuteron NMR.

Authors:  Liliya Vugmeyster; Dmitry Ostrovsky; Kirsten Penland; Gina L Hoatson; Robert L Vold
Journal:  J Phys Chem B       Date:  2013-01-22       Impact factor: 2.991

Review 10.  Studying Dynamics by Magic-Angle Spinning Solid-State NMR Spectroscopy: Principles and Applications to Biomolecules.

Authors:  Paul Schanda; Matthias Ernst
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2016-02-15       Impact factor: 9.795
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  4 in total

1.  Solid-state NMR reveals a comprehensive view of the dynamics of the flexible, disordered N-terminal domain of amyloid-β fibrils.

Authors:  Dan Fai Au; Dmitry Ostrovsky; Riqiang Fu; Liliya Vugmeyster
Journal:  J Biol Chem       Date:  2019-02-08       Impact factor: 5.157

2.  Deuteron Solid-State NMR Relaxation Measurements Reveal Two Distinct Conformational Exchange Processes in the Disordered N-Terminal Domain of Amyloid-β Fibrils.

Authors:  Liliya Vugmeyster; Dan Fai Au; Dmitry Ostrovsky; Riqiang Fu
Journal:  Chemphyschem       Date:  2019-06-14       Impact factor: 3.102

3.  Comparative Hydrophobic Core Dynamics Between Wild-Type Amyloid-β Fibrils, Glutamate-3 Truncation, and Serine-8 Phosphorylation.

Authors:  Liliya Vugmeyster; Dan Fai Au; Matthew C Smith; Dmitry Ostrovsky
Journal:  Chemphyschem       Date:  2021-12-13       Impact factor: 3.520

Review 4.  Recent developments in deuterium solid-state NMR for the detection of slow motions in proteins.

Authors:  Liliya Vugmeyster
Journal:  Solid State Nucl Magn Reson       Date:  2021-01-07       Impact factor: 2.293
  4 in total

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