Giacomo Savini1, Domenico Schiano-Lomoriello2, Kenneth J Hoffer2. 1. From G.B. Bietti Eye Foundation IRCCS (Savini, Schiano-Lomoriello), Rome, Italy; Stein Eye Institute (Hoffer), University of California, Los Angeles, and St. Mary's Eye Center (Hoffer), Santa Monica, California, USA. Electronic address: giacomo.savini@alice.it. 2. From G.B. Bietti Eye Foundation IRCCS (Savini, Schiano-Lomoriello), Rome, Italy; Stein Eye Institute (Hoffer), University of California, Los Angeles, and St. Mary's Eye Center (Hoffer), Santa Monica, California, USA.
Abstract
PURPOSE: To evaluate the repeatability of automatic measurements by a new anterior segment optical coherence tomographer (AS-OCT) combined with Placido topography and their agreement with those provided by 2 rotating Scheimpflug cameras. SETTING: G.B. Bietti Foundation IRCCS, Rome, Italy. DESIGN: Evaluation of a diagnostic test instrument. METHODS: Unoperated eyes and eyes with previous myopic excimer laser surgery were analyzed. Three consecutive scans were acquired with an AS-OCT device (MS-39) and 1 with 2 rotating Scheimpflug cameras (Pentacam HR and Sirius). The following parameters were evaluated: simulated keratometry, posterior and total corneal power, total corneal astigmatism, corneal asphericity, thinnest corneal thickness, central epithelial thickness, corneal diameter, and aqueous depth. Repeatability was assessed using test-retest variability, the coefficient of variation (CoV), and the intraclass correlation coefficient; agreement was assessed by the 95% limits of agreement. RESULTS: The study comprised 96 unoperated eyes and 43 eyes with previous myopic excimer laser surgery. High repeatability was achieved in both groups, as shown by a CoV less than 1.0% for most parameters. The repeatability of epithelial thickness was slightly lower than that of the whole corneal thickness, although the CoV was still good (1.87% in unoperated eyes; 3.28% in post-refractive surgery eyes). Moderate repeatability was found for total corneal astigmatism measurements, with a CoV greater than 20.0%. Agreement with Scheimpflug cameras was high for aqueous depth and thinnest corneal thickness and moderate for most other parameters. CONCLUSION: The high repeatability of automatic measurements by the new AS-OCT device supports its use in clinical practice.
PURPOSE: To evaluate the repeatability of automatic measurements by a new anterior segment optical coherence tomographer (AS-OCT) combined with Placido topography and their agreement with those provided by 2 rotating Scheimpflug cameras. SETTING: G.B. Bietti Foundation IRCCS, Rome, Italy. DESIGN: Evaluation of a diagnostic test instrument. METHODS: Unoperated eyes and eyes with previous myopic excimer laser surgery were analyzed. Three consecutive scans were acquired with an AS-OCT device (MS-39) and 1 with 2 rotating Scheimpflug cameras (Pentacam HR and Sirius). The following parameters were evaluated: simulated keratometry, posterior and total corneal power, total corneal astigmatism, corneal asphericity, thinnest corneal thickness, central epithelial thickness, corneal diameter, and aqueous depth. Repeatability was assessed using test-retest variability, the coefficient of variation (CoV), and the intraclass correlation coefficient; agreement was assessed by the 95% limits of agreement. RESULTS: The study comprised 96 unoperated eyes and 43 eyes with previous myopic excimer laser surgery. High repeatability was achieved in both groups, as shown by a CoV less than 1.0% for most parameters. The repeatability of epithelial thickness was slightly lower than that of the whole corneal thickness, although the CoV was still good (1.87% in unoperated eyes; 3.28% in post-refractive surgery eyes). Moderate repeatability was found for total corneal astigmatism measurements, with a CoV greater than 20.0%. Agreement with Scheimpflug cameras was high for aqueous depth and thinnest corneal thickness and moderate for most other parameters. CONCLUSION: The high repeatability of automatic measurements by the new AS-OCT device supports its use in clinical practice.