PURPOSE: Evaluation of the influence of iterative reconstruction, tube settings and patient habitus on the accuracy of iodine quantification with dual-layer spectral CT (DL-CT). MATERIAL AND METHODS: A CT abdomen phantom with different extension rings and four iodine inserts (1, 2, 5 and 10 mg/ml) was scanned on a DL-CT. The phantom was scanned with tube-voltages of 120 and 140 kVp and CTDIvol of 2.5, 5, 10 and 20 mGy. Reconstructions were performed for eight levels of iterative reconstruction (i0-i7). Diagnostic dose levels are classified depending on patient-size and radiation dose. RESULTS: Measurements of iodine concentration showed accurate and reliable results. Taking all CTDIvol-levels into account, the mean absolute percentage difference (MAPD) showed less accuracy for low CTDIvol-levels (2.5 mGy: 34.72%) than for high CTDIvol-levels (20 mGy: 5.89%). At diagnostic dose levels, accurate quantification of iodine was possible (MAPD 3.38%). Level of iterative reconstruction did not significantly influence iodine measurements. Iodine quantification worked more accurately at a tube voltage of 140 kVp. Phantom size had a considerable effect only at low-dose-levels; at diagnostic dose levels the effect of phantom size decreased (MAPD <5% for all phantom sizes). CONCLUSION: With DL-CT, even low iodine concentrations can be accurately quantified. Accuracies are higher when diagnostic radiation doses are employed.
PURPOSE: Evaluation of the influence of iterative reconstruction, tube settings and patient habitus on the accuracy of iodine quantification with dual-layer spectral CT (DL-CT). MATERIAL AND METHODS: A CT abdomen phantom with different extension rings and four iodine inserts (1, 2, 5 and 10 mg/ml) was scanned on a DL-CT. The phantom was scanned with tube-voltages of 120 and 140 kVp and CTDIvol of 2.5, 5, 10 and 20 mGy. Reconstructions were performed for eight levels of iterative reconstruction (i0-i7). Diagnostic dose levels are classified depending on patient-size and radiation dose. RESULTS: Measurements of iodine concentration showed accurate and reliable results. Taking all CTDIvol-levels into account, the mean absolute percentage difference (MAPD) showed less accuracy for low CTDIvol-levels (2.5 mGy: 34.72%) than for high CTDIvol-levels (20 mGy: 5.89%). At diagnostic dose levels, accurate quantification of iodine was possible (MAPD 3.38%). Level of iterative reconstruction did not significantly influence iodine measurements. Iodine quantification worked more accurately at a tube voltage of 140 kVp. Phantom size had a considerable effect only at low-dose-levels; at diagnostic dose levels the effect of phantom size decreased (MAPD <5% for all phantom sizes). CONCLUSION: With DL-CT, even low iodine concentrations can be accurately quantified. Accuracies are higher when diagnostic radiation doses are employed.
Authors: Jessica C Hsu; Lenitza M Nieves; Oshra Betzer; Tamar Sadan; Peter B Noël; Rachela Popovtzer; David P Cormode Journal: Wiley Interdiscip Rev Nanomed Nanobiotechnol Date: 2020-05-22
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Authors: Anushri Parakh; Chansik An; Simon Lennartz; Prabhakar Rajiah; Benjamin M Yeh; Frank J Simeone; Dushyant V Sahani; Avinash R Kambadakone Journal: Radiographics Date: 2021-02-19 Impact factor: 5.333
Authors: Andreas P Sauter; Johannes Hammel; Sebastian Ehn; Klaus Achterhold; Felix K Kopp; Melanie A Kimm; Kai Mei; Alexis Laugerette; Franz Pfeiffer; Ernst J Rummeny; Daniela Pfeiffer; Peter B Noël Journal: Sci Rep Date: 2019-04-09 Impact factor: 4.379
Authors: Andreas P Sauter; Nadav Shapira; Felix K Kopp; Juliane Aichele; Jannis Bodden; Andreas Knipfer; Ernst J Rummeny; Peter B Noël Journal: Eur J Radiol Open Date: 2020-05-07