Kristi Reynolds1, Sharon H Saydah2, Scott Isom3, Jasmin Divers4, Jean M Lawrence5, Dana Dabelea6, Elizabeth J Mayer-Davis7, Giuseppina Imperatore8, Ronny A Bell9, Richard F Hamman10. 1. Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: Kristi.Reynolds@kp.org. 2. Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: zle0@cdc.gov. 3. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United States. Electronic address: sisom@wakehealth.edu. 4. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United States. Electronic address: jdivers@wakehealth.edu. 5. Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: Jean.M.Lawrence@kp.org. 6. Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, United States. Electronic address: Dana.Dabelea@ucdenver.edu. 7. Department of Nutrition, University of North Carolina, Chapel Hill, NC, United States; Department of Medicine, University of North Carolina, Chapel Hill, NC, United States. Electronic address: mayerdav@email.unc.edu. 8. Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: gai5@cdc.gov. 9. Department of Public Health, East Carolina University, Greenville, NC, United States. Electronic address: bellr16@ecu.edu. 10. Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, United States. Electronic address: Richard.Hamman@ucdenver.edu.
Abstract
AIMS: To estimate short-term mortality rates for individuals with type 1 or type 2 diabetes diagnosed before age 20 years from the SEARCH for Diabetes in Youth study. METHODS: We included 8358 individuals newly-diagnosed with type 1 (n = 6840) or type 2 (n = 1518) diabetes from 1/1/2002-12/31/2008. We searched the National Death Index through 12/31/2010. We calculated standardized mortality ratios (SMRs) based on age, sex, and race for the comparable US population in the geographic areas of the SEARCH study. RESULTS: During 44,893 person-years (PY) of observation (median follow-up = 5.3 years), 41 individuals died (91.3 deaths/100,000 PY); 26 with type 1 (70.6 deaths/100,000 PY) and 15 with type 2 (185.6 deaths/100,000 PY) diabetes. The expected mortality rate was 70.9 deaths/100,000 PY. The overall SMR (95% CI) was 1.3 (1.0, 1.8) and was high among individuals with type 2 diabetes 2.4 (1.3, 3.9), females 2.2 (1.3, 3.3), 15-19 year olds 2.7 (1.7,4.0), and non-Hispanic blacks 2.1 (1.2, 3.4). CONCLUSIONS: Compared to the state populations of similar age, sex, and race, our results show excess mortality in individuals with type 2 diabetes, females, older youth, and non-Hispanic blacks. We did not observe excess short-term mortality in individuals with type 1 diabetes.
AIMS: To estimate short-term mortality rates for individuals with type 1 or type 2 diabetes diagnosed before age 20 years from the SEARCH for Diabetes in Youth study. METHODS: We included 8358 individuals newly-diagnosed with type 1 (n = 6840) or type 2 (n = 1518) diabetes from 1/1/2002-12/31/2008. We searched the National Death Index through 12/31/2010. We calculated standardized mortality ratios (SMRs) based on age, sex, and race for the comparable US population in the geographic areas of the SEARCH study. RESULTS: During 44,893 person-years (PY) of observation (median follow-up = 5.3 years), 41 individuals died (91.3 deaths/100,000 PY); 26 with type 1 (70.6 deaths/100,000 PY) and 15 with type 2 (185.6 deaths/100,000 PY) diabetes. The expected mortality rate was 70.9 deaths/100,000 PY. The overall SMR (95% CI) was 1.3 (1.0, 1.8) and was high among individuals with type 2 diabetes 2.4 (1.3, 3.9), females 2.2 (1.3, 3.3), 15-19 year olds 2.7 (1.7,4.0), and non-Hispanic blacks 2.1 (1.2, 3.4). CONCLUSIONS: Compared to the state populations of similar age, sex, and race, our results show excess mortality in individuals with type 2 diabetes, females, older youth, and non-Hispanic blacks. We did not observe excess short-term mortality in individuals with type 1 diabetes.
Authors: Meda E Pavkov; Peter H Bennett; William C Knowler; Jonathan Krakoff; Maurice L Sievers; Robert G Nelson Journal: JAMA Date: 2006-07-26 Impact factor: 56.272
Authors: Raynard E Washington; Trevor J Orchard; Vincent C Arena; Ronald E LaPorte; Aaron M Secrest; Eugene S Tull Journal: Diabetes Res Clin Pract Date: 2013-12-27 Impact factor: 5.602
Authors: Maria I Constantino; Lynda Molyneaux; Franziska Limacher-Gisler; Abdulghani Al-Saeed; Connie Luo; Ted Wu; Stephen M Twigg; Dennis K Yue; Jencia Wong Journal: Diabetes Care Date: 2013-07-11 Impact factor: 19.112
Authors: Thomas R Hird; Ella Zomer; Alice Owen; Lei Chen; Zanfina Ademi; Dianna J Magliano; Danny Liew Journal: Diabetologia Date: 2019-04-27 Impact factor: 10.122
Authors: Jean M Lawrence; Kristi Reynolds; Sharon H Saydah; Amy Mottl; Catherine Pihoker; Dana Dabelea; Lawrence Dolan; Leora Henkin; Angela D Liese; Scott Isom; Jasmin Divers; Lynne Wagenknecht Journal: Diabetes Care Date: 2021-10-04 Impact factor: 19.112
Authors: Jean M Lawrence; Jasmin Divers; Scott Isom; Sharon Saydah; Giuseppina Imperatore; Catherine Pihoker; Santica M Marcovina; Elizabeth J Mayer-Davis; Richard F Hamman; Lawrence Dolan; Dana Dabelea; David J Pettitt; Angela D Liese Journal: JAMA Date: 2021-08-24 Impact factor: 157.335
Authors: Julia Hudnut-Beumler; Jill L Kaar; Anya Taylor; Megan M Kelsey; Kristen J Nadeau; Philip Zeitler; Janet Snell-Bergeon; Laura Pyle; Melanie Cree-Green Journal: Pediatr Diabetes Date: 2021-04-27 Impact factor: 3.409
Authors: Dana Dabelea; Katherine A Sauder; Elizabeth T Jensen; Amy K Mottl; Alyssa Huang; Catherine Pihoker; Richard F Hamman; Jean Lawrence; Lawrence M Dolan; Ralph D' Agostino; Lynne Wagenknecht; Elizabeth J Mayer-Davis; Santica M Marcovina Journal: Ann N Y Acad Sci Date: 2021-02-05 Impact factor: 6.499
Authors: Dianna J Magliano; Julian W Sacre; Jessica L Harding; Edward W Gregg; Paul Z Zimmet; Jonathan E Shaw Journal: Nat Rev Endocrinol Date: 2020-03-20 Impact factor: 43.330
Authors: Thaddäus Tönnies; Giuseppina Imperatore; Annika Hoyer; Sharon H Saydah; Ralph B D'Agostino; Jasmin Divers; Scott Isom; Dana Dabelea; Jean M Lawrence; Elizabeth J Mayer-Davis; Catherine Pihoker; Lawrence Dolan; Ralph Brinks Journal: Ann Epidemiol Date: 2019-07-12 Impact factor: 6.996
Authors: Corinna Koebnick; Giuseppina Imperatore; Elizabeth T Jensen; Jeanette M Stafford; Amy S Shah; Amy K Mottl; Ronny A Bell; Dana Dabelea; Angela D Liese; Santica M Marcovina; Ralph B D'Agostino; Elaine M Urbina; Jean M Lawrence Journal: J Clin Hypertens (Greenwich) Date: 2020-04-15 Impact factor: 2.885