Amy Sanghavi Shah1, Mamta Jaiswal2, Dana Dabelea3, Jasmin Divers4, Scott Isom5, Angela D Liese6, Jean M Lawrence7, Grace Kim8, Elaine M Urbina9. 1. Cincinnati Children's Hospital Medical Center and the University of Cincinnati, United States of America. Electronic address: amy.shah@cchmc.org. 2. Department of Neurology, University of Michigan, Ann Arbor, MI, United States of America. 3. Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, United States of America. 4. Division of Health Services Research, NYU Long Island School of Medicine, Mineola, NY, United States of America. 5. Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, United States of America. 6. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States of America. 7. Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States of America. 8. Seattle Children's Hospital, Seattle, WA, United States of America. 9. Cincinnati Children's Hospital Medical Center and the University of Cincinnati, United States of America.
Abstract
AIMS: To evaluate cardiovascular risk factors and heart rate variability (HRV) in young adults with type 2 diabetes and arterial stiffness and to explore the relationship between HRV and arterial stiffness. METHODS: We studied 185 young adults with youth-onset T2D enrolled in the SEARCH for Diabetes in Youth Study. Cardiovascular risk factors and HRV were compared between individuals with and without type 2 diabetes and arterial stiffness (defined as a pulse wave velocity greater than the 90th percentile of healthy controls, >6.767 m/s). Semiparametric regression evaluated the independent relationship between HRV and PWV. RESULTS: Participants with T2D and arterial stiffness were more likely to be older, non-Hispanic Black, have higher systolic and diastolic blood pressure, greater adiposity and obesity-related dyslipidemia (higher triglycerides and lower HDLC). Participants with T2D and arterial stiffness also had lower overall HRV (lower SDNN) with parasympathetic loss (lower RMSSD and PNN50), p < 0.05. Lower HRV tended to be but was not significantly associated with arterial stiffness after adjustment for age, race/ethnicity, sex and cardiovascular risk factors (beta coefficient = -1.11, p = 0.08). CONCLUSIONS: Youth with T2D and arterial stiffness have a worse cardiovascular risk profile, specifically risk factors related to the metabolic syndrome and lower HRV.
AIMS: To evaluate cardiovascular risk factors and heart rate variability (HRV) in young adults with type 2 diabetes and arterial stiffness and to explore the relationship between HRV and arterial stiffness. METHODS: We studied 185 young adults with youth-onset T2D enrolled in the SEARCH for Diabetes in Youth Study. Cardiovascular risk factors and HRV were compared between individuals with and without type 2 diabetes and arterial stiffness (defined as a pulse wave velocity greater than the 90th percentile of healthy controls, >6.767 m/s). Semiparametric regression evaluated the independent relationship between HRV and PWV. RESULTS:Participants with T2D and arterial stiffness were more likely to be older, non-Hispanic Black, have higher systolic and diastolic blood pressure, greater adiposity and obesity-related dyslipidemia (higher triglycerides and lower HDLC). Participants with T2D and arterial stiffness also had lower overall HRV (lower SDNN) with parasympathetic loss (lower RMSSD and PNN50), p < 0.05. Lower HRV tended to be but was not significantly associated with arterial stiffness after adjustment for age, race/ethnicity, sex and cardiovascular risk factors (beta coefficient = -1.11, p = 0.08). CONCLUSIONS: Youth with T2D and arterial stiffness have a worse cardiovascular risk profile, specifically risk factors related to the metabolic syndrome and lower HRV.
Authors: Amy S Shah; Dana Dabelea; Jennifer W Talton; Elaine M Urbina; Ralph B D Agostino; R Paul Wadwa; Santica Marcovina; Richard F Hamman; Stephen R Daniels; Lawrence M Dolan Journal: J Pediatr Date: 2014-03-27 Impact factor: 4.406
Authors: Melanie Cree-Green; Bryan C Bergman; Eda Cengiz; Larry A Fox; Tamara S Hannon; Kellee Miller; Brandon Nathan; Laura Pyle; Darcy Kahn; Michael Tansey; Eileen Tichy; Eva Tsalikian; Ingrid Libman; Kristen J Nadeau Journal: J Clin Endocrinol Metab Date: 2019-08-01 Impact factor: 5.958
Authors: Lorraine Levitt Katz; Samuel S Gidding; Fida Bacha; Kathryn Hirst; Siripoom McKay; Laura Pyle; Joao A C Lima Journal: Pediatr Diabetes Date: 2014-01-22 Impact factor: 4.866
Authors: M Piepoli; P Sleight; S Leuzzi; F Valle; G Spadacini; C Passino; J Johnston; L Bernardi Journal: Circulation Date: 1997-04-01 Impact factor: 29.690
Authors: David M Maahs; Stephen R Daniels; Sarah D de Ferranti; Helén L Dichek; Joseph Flynn; Benjamin I Goldstein; Aaron S Kelly; Kristen J Nadeau; Pamela Martyn-Nemeth; Stavroula K Osganian; Laurie Quinn; Amy S Shah; Elaine Urbina Journal: Circulation Date: 2014-08-28 Impact factor: 29.690
Authors: Fida Bacha; Samuel S Gidding; Laura Pyle; Lorraine Levitt Katz; Andrea Kriska; Kristen J Nadeau; Joao A C Lima Journal: J Pediatr Date: 2016-08-04 Impact factor: 4.406
Authors: Amy S Shah; Laure El Ghormli; Samuel S Gidding; Kara S Hughan; Lorraine E Levitt Katz; Dorit Koren; Jeanie B Tryggestad; Fida Bacha; Barbara H Braffett; Silva Arslanian; Elaine M Urbina Journal: Acta Diabetol Date: 2021-09-20 Impact factor: 4.280
Authors: Amy S Shah; Scott Isom; Ralph D'Agostino; Lawrence M Dolan; Dana Dabelea; Giuseppina Imperatore; Amy Mottl; Eva Lustigova; Catherine Pihoker; Santica Marcovina; Elaine M Urbina Journal: Diabetes Care Date: 2022-07-07 Impact factor: 17.152