Literature DB >> 29588035

Xenon Anesthesia and CT: Noninvasive Measures of Brain Anesthetic Concentration.

Andrew McKinstry-Wu1, Charles W Carspecken2, Alex Proekt2, Max B Kelz2.   

Abstract

The existence of a barrier between anesthetic behavioral state transitions has been observed across phyla, but demonstrating that such a barrier exists and is not a pharmacokinetic artifact has not yet been possible in humans. Such an investigation requires temporally precise information regarding the brain concentration of anesthetic in order to demonstrate the specific pharmacokinetic-pharmacodynamic mismatch that is hysteresis. We propose a method to noninvasively determine brain tissue anesthetic concentration using computerized tomography and the radiopaque gaseous anesthetic xenon. Such a technique can be used to investigate pharmacokinetic-pharmacodynamic mismatches in humans.
© 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Anesthesia; Computerized tomography; Human; Hysteresis; Xenon

Mesh：

Substances：

Year:  2018        PMID： 29588035      PMCID： PMC6241249          DOI： 10.1016/bs.mie.2018.01.011

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  17 in total

Review 1.  Xenon, a modern anaesthesia gas.

Authors:  K Hecker; J H Baumert; N Horn; R Rossaint
Journal:  Minerva Anestesiol       Date:  2004-05       Impact factor: 3.051

Review 2.  Xenon Anesthesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Authors:  Lawrence Siu-Chun Law; Elaine Ah-Gi Lo; Tong Joo Gan
Journal:  Anesth Analg       Date:  2016-03       Impact factor: 5.108

Review 3.  Fluorescence optical imaging in anticancer drug delivery.

Authors:  Tomáš Etrych; Henrike Lucas; Olga Janoušková; Petr Chytil; Thomas Mueller; Karsten Mäder
Journal:  J Control Release       Date:  2016-02-16       Impact factor: 9.776

4.  Xenon enhanced CT for analysis of cerebral integrity, perfusion, and blood flow.

Authors:  B P Drayer; S K Wolfson; O M Reinmuth; M Dujovny; M Boehnke; E E Cook
Journal:  Stroke       Date:  1978 Mar-Apr       Impact factor: 7.914

5.  Xenon measurement in breathing systems: a comparison of ultrasonic and thermal conductivity methods.

Authors:  R King; M Bretland; A Wilkes; J Dingley
Journal:  Anaesthesia       Date:  2005-12       Impact factor: 6.955

6.  Diazepam produces disinhibitory cognitive effects in male volunteers.

Authors:  J B Deakin; M R F Aitken; J H Dowson; T W Robbins; B J Sahakian
Journal:  Psychopharmacology (Berl)       Date:  2003-12-19       Impact factor: 4.530

7.  Bispectral index, entropy, and quantitative electroencephalogram during single-agent xenon anesthesia.

Authors:  Ruut M Laitio; Kimmo Kaskinoro; Mika O K Särkelä; Kaike K Kaisti; Elina Salmi; Anu Maksimow; Jaakko W Långsjö; Riku Aantaa; Katja Kangas; Satu Jääskeläinen; Harry Scheinin
Journal:  Anesthesiology       Date:  2008-01       Impact factor: 7.892

8.  A conserved behavioral state barrier impedes transitions between anesthetic-induced unconsciousness and wakefulness: evidence for neural inertia.

Authors:  Eliot B Friedman; Yi Sun; Jason T Moore; Hsiao-Tung Hung; Qing Cheng Meng; Priyan Perera; William J Joiner; Steven A Thomas; Roderic G Eckenhoff; Amita Sehgal; Max B Kelz
Journal:  PLoS One       Date:  2010-07-30       Impact factor: 3.240

9.  Monitoring xenon in the breathing circuit with a thermal conductivity sensor. Comparison with a mass spectrometer and implications on monitoring other gases.

Authors:  Martin Luginbühl; Rolf Lauber; Peter Feigenwinter; Alex M Zbinden
Journal:  J Clin Monit Comput       Date:  2002-01       Impact factor: 2.502

10.  Regional myocardial perfusion abnormalities on xenon-133 imaging in patients with angina pectoris and normal coronary arteries.

Authors:  O Korhola; M Valle; M H Frick; M Wiljasalo; E Riihimäki
Journal:  Am J Cardiol       Date:  1977-03       Impact factor: 2.778
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  1 in total

1.  Explaining anaesthetic hysteresis with effect-site equilibration.

Authors:  Alex Proekt; Max B Kelz
Journal:  Br J Anaesth       Date:  2020-10-17       Impact factor: 9.166
  1 in total

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