| Literature DB >> 29245064 |
Ines Lucia Patop1, Sebastian Kadener2.
Abstract
Exonic circular RNAs (circRNAs) are mostly generated from exons of protein-coding genes and, in many cases, are more abundant that the linear product from their hosting gene. Certain circRNAs are very abundant in the brain and in non-dividing cells; and many also show physiological-specific and tissue-specific expression. Moreover, recent work has demonstrated that some circRNAs are functional. Lately an important number of research articles have pointed a relation between cancer and certain circRNAs. In this review, we describe general advances in the field regarding circRNA biogenesis and functions in relationship with cancer. Also, we summarize some necessary precautions to work with circRNA that are particularly relevant to cancer-related studies.Entities:
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Year: 2017 PMID： 29245064 PMCID： PMC5877416 DOI： 10.1016/j.gde.2017.11.007
Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578