Literature DB >> 29185700

Design and Application of a DNA-Encoded Macrocyclic Peptide Library.

Zhengrong Zhu1, Alex Shaginian1, LaShadric C Grady1, Thomas O'Keeffe1, Xiangguo E Shi1, Christopher P Davie1, Graham L Simpson2, Jeffrey A Messer1, Ghotas Evindar1, Robert N Bream2, Praew P Thansandote2, Naomi R Prentice2, Andrew M Mason2, Sandeep Pal2.   

Abstract

A DNA-encoded macrocyclic peptide library was designed and synthesized with 2.4 × 1012 members composed of 4-20 natural and non-natural amino acids. Affinity-based selection was performed against two therapeutic targets, VHL and RSV N protein. On the basis of selection data, some peptides were selected for resynthesis without a DNA tag, and their activity was confirmed.

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Year:  2017        PMID： 29185700     DOI： 10.1021/acschembio.7b00852

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  22 in total

Review 1.  Nucleic Acid-Barcoding Technologies: Converting DNA Sequencing into a Broad-Spectrum Molecular Counter.

Authors:  Glen Liszczak; Tom W Muir
Journal:  Angew Chem Int Ed Engl       Date:  2019-02-06       Impact factor: 15.336

2.  DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules.

Authors:  Christopher J Gerry; Mathias J Wawer; Paul A Clemons; Stuart L Schreiber
Journal:  J Am Chem Soc       Date:  2019-06-25       Impact factor: 15.419

3.  Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis.

Authors:  James P Phelan; Simon B Lang; Jaehoon Sim; Simon Berritt; Andrew J Peat; Katelyn Billings; Lijun Fan; Gary A Molander
Journal:  J Am Chem Soc       Date:  2019-02-12       Impact factor: 15.419

Review 4.  Chemical composition of DNA-encoded libraries, past present and future.

Authors:  Paige Dickson; Thomas Kodadek
Journal:  Org Biomol Chem       Date:  2019-05-15       Impact factor: 3.876

Review 5.  DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges.

Authors:  Adrián Gironda-Martínez; Etienne J Donckele; Florent Samain; Dario Neri
Journal:  ACS Pharmacol Transl Sci       Date:  2021-06-14

6.  Library Synthesis: Building Block Selection, Handling, and Tracking.

Authors:  Katelyn J Billings; Melissa C Grenier-Davies
Journal:  Methods Mol Biol       Date:  2022

7.  Genetically-encoded discovery of proteolytically stable bicyclic inhibitors for morphogen NODAL.

Authors:  Jeffrey Y-K Wong; Raja Mukherjee; Jiayuan Miao; Olena Bilyk; Vivian Triana; Mark Miskolzie; Antoine Henninot; John J Dwyer; Serhii Kharchenko; Anna Iampolska; Dmitriy M Volochnyuk; Yu-Shan Lin; Lynne-Marie Postovit; Ratmir Derda
Journal:  Chem Sci       Date:  2021-06-17       Impact factor: 9.825

8.  Off-DNA DNA-Encoded Library Affinity Screening.

Authors:  Amber L Hackler; Forrest G FitzGerald; Vuong Q Dang; Alexander L Satz; Brian M Paegel
Journal:  ACS Comb Sci       Date:  2019-12-31       Impact factor: 3.784

Review 9.  DNA-encoded chemical libraries - achievements and remaining challenges.

Authors:  Nicholas Favalli; Gabriele Bassi; Jörg Scheuermann; Dario Neri
Journal:  FEBS Lett       Date:  2018-05-10       Impact factor: 4.124

10.  DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry.

Authors:  Bing Xia; G Joseph Franklin; Xiaojie Lu; Katie L Bedard; LaShadric C Grady; Jennifer D Summerfield; Eric X Shi; Bryan W King; Kenneth E Lind; Cynthia Chiu; Eleanor Watts; Vera Bodmer; Xiaopeng Bai; Lisa A Marcaurelle
Journal:  ACS Med Chem Lett       Date:  2021-06-03       Impact factor: 4.632
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