Literature DB >> 36083536

Library Synthesis: Building Block Selection, Handling, and Tracking.

Katelyn J Billings1, Melissa C Grenier-Davies2.   

Abstract

Careful selection and manipulation of small molecule building blocks is crucial to the success of a DNA-encoded library. Building block selection impacts the quality of the hits arising out of a selection assay, while proper sample handling and tracking ensure follow-up synthetic work is done with the appropriate synthetic map in mind. In this chapter, possible strategies for building block selection are outlined, as well as best practices for handling and tracking samples to be used for validation and library synthesis.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  2D barcoded tubes; Building blocks; DNA-encoded library; Diversity selection; Library optimization; Property filters; Reactivity; Small molecules

Mesh：

Year:  2022        PMID： 36083536     DOI： 10.1007/978-1-0716-2545-3_1

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

1.  Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.

Authors:  Hongfeng Deng; Jingye Zhou; Flora S Sundersingh; Jennifer Summerfield; Don Somers; Jeffrey A Messer; Alexander L Satz; Nicolas Ancellin; Christopher C Arico-Muendel; Katie L Sargent Bedard; Arthur Beljean; Svetlana L Belyanskaya; Ryan Bingham; Sarah E Smith; Eric Boursier; Paul Carter; Paolo A Centrella; Matthew A Clark; Chun-Wa Chung; Christopher P Davie; Jennifer L Delorey; Yun Ding; G Joseph Franklin; LaShadric C Grady; Kenny Herry; Clare Hobbs; Christopher S Kollmann; Barry A Morgan; Laura J Pothier Kaushansky; Quan Zhou
Journal:  ACS Med Chem Lett       Date:  2015-07-21       Impact factor: 4.345

2.  Design, synthesis and selection of DNA-encoded small-molecule libraries.

Authors:  Matthew A Clark; Raksha A Acharya; Christopher C Arico-Muendel; Svetlana L Belyanskaya; Dennis R Benjamin; Neil R Carlson; Paolo A Centrella; Cynthia H Chiu; Steffen P Creaser; John W Cuozzo; Christopher P Davie; Yun Ding; G Joseph Franklin; Kurt D Franzen; Malcolm L Gefter; Steven P Hale; Nils J V Hansen; David I Israel; Jinwei Jiang; Malcolm J Kavarana; Michael S Kelley; Christopher S Kollmann; Fan Li; Kenneth Lind; Sibongile Mataruse; Patricia F Medeiros; Jeffrey A Messer; Paul Myers; Heather O'Keefe; Matthew C Oliff; Cecil E Rise; Alexander L Satz; Steven R Skinner; Jennifer L Svendsen; Lujia Tang; Kurt van Vloten; Richard W Wagner; Gang Yao; Baoguang Zhao; Barry A Morgan
Journal:  Nat Chem Biol       Date:  2009-08-02       Impact factor: 15.040

3.  A scoring scheme for discriminating between drugs and nondrugs.

Authors:  J Sadowski; H Kubinyi
Journal:  J Med Chem       Date:  1998-08-27       Impact factor: 7.446

4.  Analysis of Current DNA Encoded Library Screening Data Indicates Higher False Negative Rates for Numerically Larger Libraries.

Authors:  Alexander L Satz; Remo Hochstrasser; Ann C Petersen
Journal:  ACS Comb Sci       Date:  2017-03-17       Impact factor: 3.784

5.  Design and Application of a DNA-Encoded Macrocyclic Peptide Library.

Authors:  Zhengrong Zhu; Alex Shaginian; LaShadric C Grady; Thomas O'Keeffe; Xiangguo E Shi; Christopher P Davie; Graham L Simpson; Jeffrey A Messer; Ghotas Evindar; Robert N Bream; Praew P Thansandote; Naomi R Prentice; Andrew M Mason; Sandeep Pal
Journal:  ACS Chem Biol       Date:  2017-12-04       Impact factor: 5.100

6.  Price-Focused Analysis of Commercially Available Building Blocks for Combinatorial Library Synthesis.

Authors:  Tuomo Kalliokoski
Journal:  ACS Comb Sci       Date:  2015-09-15       Impact factor: 3.784

7.  Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).

Authors:  Hongfeng Deng; Heather O'Keefe; Christopher P Davie; Kenneth E Lind; Raksha A Acharya; G Joseph Franklin; Jonathan Larkin; Rosalie Matico; Michael Neeb; Monique M Thompson; Thomas Lohr; Jeffrey W Gross; Paolo A Centrella; Gary K O'Donovan; Katie L Sargent Bedard; Kurt van Vloten; Sibongile Mataruse; Steven R Skinner; Svetlana L Belyanskaya; Tiffany Y Carpenter; Todd W Shearer; Matthew A Clark; John W Cuozzo; Christopher C Arico-Muendel; Barry A Morgan
Journal:  J Med Chem       Date:  2012-08-14       Impact factor: 7.446

8.  DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.

Authors:  Philip A Harris; Bryan W King; Deepak Bandyopadhyay; Scott B Berger; Nino Campobasso; Carol A Capriotti; Julie A Cox; Lauren Dare; Xiaoyang Dong; Joshua N Finger; LaShadric C Grady; Sandra J Hoffman; Jae U Jeong; James Kang; Viera Kasparcova; Ami S Lakdawala; Ruth Lehr; Dean E McNulty; Rakesh Nagilla; Michael T Ouellette; Christina S Pao; Alan R Rendina; Michelle C Schaeffer; Jennifer D Summerfield; Barbara A Swift; Rachel D Totoritis; Paris Ward; Aming Zhang; Daohua Zhang; Robert W Marquis; John Bertin; Peter J Gough
Journal:  J Med Chem       Date:  2016-02-23       Impact factor: 7.446

9.  Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists.

Authors:  Christopher S Kollmann; Xiaopeng Bai; Ching-Hsuan Tsai; Hongfang Yang; Kenneth E Lind; Steven R Skinner; Zhengrong Zhu; David I Israel; John W Cuozzo; Barry A Morgan; Koichi Yuki; Can Xie; Timothy A Springer; Motomu Shimaoka; Ghotas Evindar
Journal:  Bioorg Med Chem       Date:  2014-02-07       Impact factor: 3.641

10.  Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library.

Authors:  Alexander Litovchick; Christoph E Dumelin; Sevan Habeshian; Diana Gikunju; Marie-Aude Guié; Paolo Centrella; Ying Zhang; Eric A Sigel; John W Cuozzo; Anthony D Keefe; Matthew A Clark
Journal:  Sci Rep       Date:  2015-06-10       Impact factor: 4.379
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