Literature DB >> 29172684

Faster and safer? FLASH ultra-high dose rate in radiotherapy.

Marco Durante1, Elke Bräuer-Krisch2, Mark Hill3.   

Abstract

Recent results from the Franco-Swiss team of Institute Curie and Centre Hospitalier Universitaire Vaudois demonstrate a remarkable sparing of normal tissue after irradiation at ultra-high dose rate (>40 Gy s-1). The "FLASH" radiotherapy maintains tumour control level, suggesting that ultra-high dose rate can substantially enhance the therapeutic window in radiotherapy. The results have been obtained so far only with 4-6 MeV electrons in lung and brain mouse model. Nevertheless, they have attracted a great attention for the potential clinical applications. Oxygen depletion had been discussed many years ago as a possible mechanism for reduction of the damage after exposure to ultra-high dose rate. However, the mechanism underlying the effect observed in the FLASH radiotherapy remains to be elucidated.

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Year:  2017        PMID： 29172684      PMCID： PMC5965780          DOI： 10.1259/bjr.20170628

Source DB:  PubMed          Journal:  Br J Radiol        ISSN： 0007-1285            Impact factor:   3.039


  16 in total

1.  Dose responses for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles, and by gamma rays delivered at sublimiting low dose rates.

Authors:  Michael N Cornforth; Susan M Bailey; Edwin H Goodwin
Journal:  Radiat Res       Date:  2002-07       Impact factor: 2.841

2.  Estimation of life times and diffusion distances of radicals involved in x-ray-induced DNA strand breaks of killing of mammalian cells.

Authors:  R Roots; S Okada
Journal:  Radiat Res       Date:  1975-11       Impact factor: 2.841

3.  Radiobiology. Effect of high dose rates on survival of mammalian cells.

Authors:  C D Town
Journal:  Nature       Date:  1967-08-19       Impact factor: 49.962

4.  Interaction of ion tracks in spatial and temporal proximity.

Authors:  Maximilian Stephan Kreipl; Werner Friedland; Herwig G Paretzke
Journal:  Radiat Environ Biophys       Date:  2009-07-12       Impact factor: 1.925

5.  High dose-per-pulse electron beam dosimetry: Usability and dose-rate independence of EBT3 Gafchromic films.

Authors:  Maud Jaccard; Kristoffer Petersson; Thierry Buchillier; Jean-François Germond; Maria Teresa Durán; Marie-Catherine Vozenin; Jean Bourhis; François O Bochud; Claude Bailat
Journal:  Med Phys       Date:  2017-02-08       Impact factor: 4.071

6.  Experimental Platform for Ultra-high Dose Rate FLASH Irradiation of Small Animals Using a Clinical Linear Accelerator.

Authors:  Emil Schüler; Stefania Trovati; Gregory King; Frederick Lartey; Marjan Rafat; Manuel Villegas; A Joe Praxel; Billy W Loo; Peter G Maxim
Journal:  Int J Radiat Oncol Biol Phys       Date:  2016-09-20       Impact factor: 7.038

7.  Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation.

Authors:  M Fernet; V Ponette; E Deniaud-Alexandre; J Ménissier-De Murcia; G De Murcia; N Giocanti; F Megnin-Chanet; V Favaudon
Journal:  Int J Radiat Biol       Date:  2000-12       Impact factor: 2.694

Review 8.  Revisiting the ultra-high dose rate effect: implications for charged particle radiotherapy using protons and light ions.

Authors:  P Wilson; B Jones; T Yokoi; M Hill; B Vojnovic
Journal:  Br J Radiol       Date:  2012-04-11       Impact factor: 3.039

9.  Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice.

Authors:  Vincent Favaudon; Laura Caplier; Virginie Monceau; Frédéric Pouzoulet; Mano Sayarath; Charles Fouillade; Marie-France Poupon; Isabel Brito; Philippe Hupé; Jean Bourhis; Janet Hall; Jean-Jacques Fontaine; Marie-Catherine Vozenin
Journal:  Sci Transl Med       Date:  2014-07-16       Impact factor: 17.956

10.  The etiology of treatment-related lymphopenia in patients with malignant gliomas: modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cells.

Authors:  Susannah Yovino; Lawrence Kleinberg; Stuart A Grossman; Manisha Narayanan; Eric Ford
Journal:  Cancer Invest       Date:  2013-02       Impact factor: 2.176
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  32 in total

1.  Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System.

Authors:  Eric S Diffenderfer; Ioannis I Verginadis; Michele M Kim; Khayrullo Shoniyozov; Anastasia Velalopoulou; Denisa Goia; Mary Putt; Sarah Hagan; Stephen Avery; Kevin Teo; Wei Zou; Alexander Lin; Samuel Swisher-McClure; Cameron Koch; Ann R Kennedy; Andy Minn; Amit Maity; Theresa M Busch; Lei Dong; Costas Koumenis; James Metz; Keith A Cengel
Journal:  Int J Radiat Oncol Biol Phys       Date:  2020-02-01       Impact factor: 7.038

2.  Ultra-high dose rate effect on circulating immune cells: A potential mechanism for FLASH effect?

Authors:  Jian-Yue Jin; Anxin Gu; Weili Wang; Nancy L Oleinick; Mitchell Machtay; Feng-Ming Spring Kong
Journal:  Radiother Oncol       Date:  2020-05-06       Impact factor: 6.280

3.  Simultaneous dose and dose rate optimization (SDDRO) of the FLASH effect for pencil-beam-scanning proton therapy.

Authors:  Hao Gao; Jiulong Liu; Yuting Lin; Gregory N Gan; Guillem Pratx; Fen Wang; Katja Langen; Jeffrey D Bradley; Ronny L Rotondo; Harold H Li; Ronald C Chen
Journal:  Med Phys       Date:  2021-12-07       Impact factor: 4.506

4.  Ultrafast Tracking of Oxygen Dynamics During Proton FLASH.

Authors:  Mirna El Khatib; Alexander L Van Slyke; Anastasia Velalopoulou; Michele M Kim; Khayrullo Shoniyozov; Srinivasa Rao Allu; Eric E Diffenderfer; Theresa M Busch; Rodney D Wiersma; Cameron J Koch; Sergei A Vinogradov
Journal:  Int J Radiat Oncol Biol Phys       Date:  2022-03-18       Impact factor: 8.013

5.  A sparse orthogonal collimator for small animal intensity-modulated radiation therapy. Part II: hardware development and commissioning.

Authors:  Kaley Woods; Ryan Neph; Dan Nguyen; Ke Sheng
Journal:  Med Phys       Date:  2019-11-04       Impact factor: 4.071

Review 6.  The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT.

Authors:  Eui Jung Moon; Kristoffer Petersson; Monica M Olcina
Journal:  Int J Radiat Biol       Date:  2021-11-02       Impact factor: 2.694

7.  DNA strand break induction of aqueous plasmid DNA exposed to 30 MeV protons at ultra-high dose rate.

Authors:  Daisuke Ohsawa; Yota Hiroyama; Alisa Kobayashi; Tamon Kusumoto; Hisashi Kitamura; Satoru Hojo; Satoshi Kodaira; Teruaki Konishi
Journal:  J Radiat Res       Date:  2022-03-17       Impact factor: 2.724

8.  SDDRO-joint: simultaneous dose and dose rate optimization with the joint use of transmission beams and Bragg peaks for FLASH proton therapy.

Authors:  Yuting Lin; Bowen Lin; Shujun Fu; Michael M Folkerts; Eric Abel; Jeffrey Bradley; Hao Gao
Journal:  Phys Med Biol       Date:  2021-06-14       Impact factor: 4.174

9.  Significant changes in yields of 7-hydroxy-coumarin-3-carboxylic acid produced under FLASH radiotherapy conditions.

Authors:  Tamon Kusumoto; Hisashi Kitamura; Satoru Hojo; Teruaki Konishi; Satoshi Kodaira
Journal:  RSC Adv       Date:  2020-10-27       Impact factor: 4.036

10.  The FLASH effect depends on oxygen concentration.

Authors:  Gabriel Adrian; Elise Konradsson; Michael Lempart; Sven Bäck; Crister Ceberg; Kristoffer Petersson
Journal:  Br J Radiol       Date:  2019-12-20       Impact factor: 3.629
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