Farshid Bastami1, Shahriar Shahab2, Azin Parsa3, Fatemeh Mashhadi Abbas4, Mohammad Hadi Noori Kooshki5, Mahshid Namdari6, Hamidreza Azimi Lisar7, Tohid Rafiei7, Farahnaz Fahimipour8, Majid Salehi9, Maissa Jafari10. 1. Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahed University, Tehran, Iran. sh.shahab3@gmail.com. 3. Department of Oral Radiology, Department of General and Specialized Dentistry, Academic Center for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands. a.parsa@acta.nl. 4. Department of Oral Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Department of Oral and Maxillofacial Radiology, School of Dentistry, Shahed University, Tehran, Iran. 6. Department of Biostatistics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 7. Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahed University, Tehran, Iran. 8. Department of Developmental Sciences, School of Dentistry, Marquette University, Milwaukee, WI, USA. 9. Department of Tissue Engineering and Cell Therapy, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. 10. Department of Oral Radiology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
OBJECTIVES: The main aim of this study was to investigate whether Hounsfield unit derived from computed tomography (HU/CT) and gray value derived from cone beam computed tomography (GV/CBCT) can predict the amount of new bone formation (NBF) in the defects after bone reconstruction surgeries. MATERIALS AND METHODS: Thirty calvaria defects created in 5 rabbits and grafted with both radiolucent (RL, n = 15) and radiopaque (RO, n = 15) bone substitute materials were evaluated, 8 weeks postoperatively. The defects were scanned by multislice computed tomography (Somatom®, Siemens Healthineers, Erlangen, Germany) and CBCT (NewTom VG®, Qualitative Radiology, Verona, Italy). MSCT and CBCT scans were matched to select the exact region of interest (ROI, diameter = 5 mm and height = 1 mm). HU/CT and GV/CBCT of each ROI were obtained. Mean amount of NBF in whole of the defects was measured using serial histomorphometric assessment. We investigated the correlation between HU/CT and GV/CBCT, HU/CT and NBF, and GV/CBCT and NBF generally, and separately among the RL or RO grafted defects, by linear generalized estimating equation modeling. Receiver operation characteristic analysis was performed to check the accuracy of HU/CT and GV/CBCT in diagnosing more than 10% NBF in the samples. RESULTS: There were linear correlations between HU/CT and GV/CBCT, HU/CT and NBF, and GV/CBCT and NBF. CONCLUSION: According to the results, both HU/CT and GV/CBCT can be considered as fairly good predictors for assessment of the amount of NBF following bone reconstruction surgeries.
OBJECTIVES: The main aim of this study was to investigate whether Hounsfield unit derived from computed tomography (HU/CT) and gray value derived from cone beam computed tomography (GV/CBCT) can predict the amount of new bone formation (NBF) in the defects after bone reconstruction surgeries. MATERIALS AND METHODS: Thirty calvaria defects created in 5 rabbits and grafted with both radiolucent (RL, n = 15) and radiopaque (RO, n = 15) bone substitute materials were evaluated, 8 weeks postoperatively. The defects were scanned by multislice computed tomography (Somatom®, Siemens Healthineers, Erlangen, Germany) and CBCT (NewTom VG®, Qualitative Radiology, Verona, Italy). MSCT and CBCT scans were matched to select the exact region of interest (ROI, diameter = 5 mm and height = 1 mm). HU/CT and GV/CBCT of each ROI were obtained. Mean amount of NBF in whole of the defects was measured using serial histomorphometric assessment. We investigated the correlation between HU/CT and GV/CBCT, HU/CT and NBF, and GV/CBCT and NBF generally, and separately among the RL or RO grafted defects, by linear generalized estimating equation modeling. Receiver operation characteristic analysis was performed to check the accuracy of HU/CT and GV/CBCT in diagnosing more than 10% NBF in the samples. RESULTS: There were linear correlations between HU/CT and GV/CBCT, HU/CT and NBF, and GV/CBCT and NBF. CONCLUSION: According to the results, both HU/CT and GV/CBCT can be considered as fairly good predictors for assessment of the amount of NBF following bone reconstruction surgeries.
Entities:
Keywords:
Bone regeneration; CT number; Cone beam computed tomography; Hounsfield unit; New bone formation
Authors: Masih Shahlaie; Bernard Gantes; Eloy Schulz; Matt Riggs; Max Crigger Journal: Int J Oral Maxillofac Implants Date: 2003 Mar-Apr Impact factor: 2.804
Authors: Tannaz Shapurian; Petros D Damoulis; Gary M Reiser; Terrence J Griffin; William M Rand Journal: Int J Oral Maxillofac Implants Date: 2006 Mar-Apr Impact factor: 2.804
Authors: Azin Parsa; Norliza Ibrahim; Bassam Hassan; Paul van der Stelt; Daniel Wismeijer Journal: Clin Oral Implants Res Date: 2013-12-11 Impact factor: 5.977