Literature DB >> 2907605

The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

E B Jakobovits1, U Schlokat, J L Vannice, R Derynck, A D Levinson.   

Abstract

Transforming growth factor alpha (TGF-alpha) is a transformation-responsive mitogenic polypeptide that is expressed in the brain, epithelial cells, and activated macrophages. We isolated and characterized the TGF-alpha promoter and localized the 5' end of the TGF-alpha transcript to a unique position. Surprisingly, no apparent TATA box was present in the promoter sequence, suggesting that transcription from mammalian genes can initiate at unique and specific positions from promoters lacking this sequence motif.

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Year:  1988        PMID： 2907605      PMCID： PMC365660          DOI： 10.1128/mcb.8.12.5549-5554.1988

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  31 in total

1.  Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins.

Authors:  W S Dynan; R Tjian
Journal:  Nature       Date:  1985 Aug 29-Sep 4       Impact factor: 49.962

2.  Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements.

Authors:  W Lee; P Mitchell; R Tjian
Journal:  Cell       Date:  1987-06-19       Impact factor: 41.582

3.  A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus.

Authors:  M Boshart; F Weber; G Jahn; K Dorsch-Häsler; B Fleckenstein; W Schaffner
Journal:  Cell       Date:  1985-06       Impact factor: 41.582

4.  Simian virus 40 guanine-cytosine-rich sequences function as independent transcriptional control elements in vitro.

Authors:  H Mishoe; J N Brady; M Radonovich; N P Salzman
Journal:  Mol Cell Biol       Date:  1984-12       Impact factor: 4.272

5.  Developmental expression of rat transforming growth factor-alpha mRNA.

Authors:  D C Lee; R Rochford; G J Todaro; L P Villarreal
Journal:  Mol Cell Biol       Date:  1985-12       Impact factor: 4.272

6.  Trans effect of the E1 region of adenoviruses on the expression of a prokaryotic gene in mammalian cells: resistance to 5' -CCGG- 3' methylation.

Authors:  K D Langner; U Weyer; W Doerfler
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

7.  Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

Authors:  R Derynck; D V Goeddel; A Ullrich; J U Gutterman; R D Williams; T S Bringman; W H Berger
Journal:  Cancer Res       Date:  1987-02-01       Impact factor: 12.701

8.  Differential expression of transforming growth factor-alpha during prenatal development of the mouse.

Authors:  D R Twardzik
Journal:  Cancer Res       Date:  1985-11       Impact factor: 12.701

9.  Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.

Authors:  S Ishii; Y H Xu; R H Stratton; B A Roe; G T Merlino; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

10.  Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation.

Authors:  A Rosenthal; P B Lindquist; T S Bringman; D V Goeddel; R Derynck
Journal:  Cell       Date:  1986-07-18       Impact factor: 41.582
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  21 in total

1.  Expression of transforming growth factor alpha in human tissues: immunohistochemical study and northern blot analysis.

Authors:  W Yasui; Z Q Ji; H Kuniyasu; A Ayhan; H Yokozaki; H Ito; E Tahara
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

2.  Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter.

Authors:  M C Blake; R C Jambou; A G Swick; J W Kahn; J C Azizkhan
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

3.  Identification and characterization of a regulated promoter element in the epidermal growth factor receptor gene.

Authors:  L G Hudson; K L Thompson; J Xu; G N Gill
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

4.  Functional analysis of GC element binding and transcription in the hamster dihydrofolate reductase gene promoter.

Authors:  A G Swick; M C Blake; J W Kahn; J C Azizkhan
Journal:  Nucleic Acids Res       Date:  1989-11-25       Impact factor: 16.971

Review 5.  From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease.

Authors:  Bhuminder Singh; Robert J Coffey
Journal:  Semin Cell Dev Biol       Date:  2014-03-12       Impact factor: 7.727

6.  Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 gene.

Authors:  G J Mavrothalassitis; D K Watson; T S Papas
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

7.  p53 stimulates transcription from the human transforming growth factor alpha promoter: a potential growth-stimulatory role for p53.

Authors:  T H Shin; A J Paterson; J E Kudlow
Journal:  Mol Cell Biol       Date:  1995-09       Impact factor: 4.272

8.  Lack of an initiator element is responsible for multiple transcriptional initiation sites of the TATA-less mouse thymidylate synthase promoter.

Authors:  Y Geng; L F Johnson
Journal:  Mol Cell Biol       Date:  1993-08       Impact factor: 4.272

9.  Association of transforming growth-factor alpha gene polymorphisms with nonsyndromic cleft palate only (CPO).

Authors:  R Shiang; A C Lidral; H H Ardinger; K H Buetow; P A Romitti; R G Munger; J C Murray
Journal:  Am J Hum Genet       Date:  1993-10       Impact factor: 11.025

10.  5-Azacytidine treatment of HA-A melanoma cells induces Sp1 activity and concomitant transforming growth factor alpha expression.

Authors:  T H Shin; A J Paterson; J H Grant; A A Meluch; J E Kudlow
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272
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