Literature DB >> 2991899

Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene.

S Ishii, Y H Xu, R H Stratton, B A Roe, G T Merlino, I Pastan.   

Abstract

The promoter region of the epidermal growth factor (EGF) receptor has been identified by in vitro transcription using EGF receptor genomic DNA fragments as template and by primer extension and nuclease S1 mapping using EGF receptor mRNA. Six transcriptional start sites were identified. DNA sequence analysis shows that the promoter region contains neither a "TATA box" nor a "CAAT box," has an extremely high G+C content (88%), and contains five CCGCCC repeats and four (TCC)TCCTCCTCC repeats. This promoter region is situated close to or within a DNase I-hypersensitive site in A431 human epidermoid carcinoma cells, which overproduce the EGF receptor. The EGF receptor gene promoter has some resemblance to the promoter of the hydroxymethylglutaryl-CoA reductase gene and the early promoter of simian virus 40. This similarity may offer a clue to the mechanism by which the receptor gene is regulated.

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Year:  1985        PMID： 2991899      PMCID： PMC390469          DOI： 10.1073/pnas.82.15.4920

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  47 in total

1.  Insulin and epidermal growth factor-urogastrone: affinity crosslinking to specific binding sites in rat liver membranes.

Authors:  N Sahyoun; R A Hock; M D Hollenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

2.  Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors:  A J Berk; P A Sharp
Journal:  Cell       Date:  1977-11       Impact factor: 41.582

Review 3.  Epidermal growth factor.

Authors:  G Carpenter; S Cohen
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

4.  The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence.

Authors:  C Wu; P M Bingham; K J Livak; R Holmgren; S C Elgin
Journal:  Cell       Date:  1979-04       Impact factor: 41.582

5.  Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization.

Authors:  C R Savage; S Cohen
Journal:  J Biol Chem       Date:  1972-12-10       Impact factor: 5.157

6.  Specific radiolabeling of a cell surface receptor for epidermal growth factor.

Authors:  M Das; T Miyakawa; C F Fox; R M Pruss; A Aharonov; H R Herschman
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

7.  The isolation of structural genes from libraries of eucaryotic DNA.

Authors:  T Maniatis; R C Hardison; E Lacy; J Lauer; C O'Connell; D Quon; G K Sim; A Efstratiadis
Journal:  Cell       Date:  1978-10       Impact factor: 41.582

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles.

Authors:  S Cohen; H Ushiro; C Stoscheck; M Chinkers
Journal:  J Biol Chem       Date:  1982-02-10       Impact factor: 5.157

10.  Nerve growth factor receptors on human melanoma cells in culture.

Authors:  R N Fabricant; J E De Larco; G J Todaro
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205
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  123 in total

Review 1.  Transcriptional regulation of type I receptor tyrosine kinases in the mammary gland.

Authors:  N P Bates; H C Hurst
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-04       Impact factor: 2.673

2.  Estrogen-dependent transcription of the NEL-like 2 (NELL2) gene and its role in protection from cell death.

Authors:  Eun Jung Choi; Dong Hee Kim; Jae Geun Kim; Dong Yeol Kim; Jung Dae Kim; Ok Ju Seol; Choon Soo Jeong; Jeong Woo Park; Min Young Choi; Sung Goo Kang; Maria E Costa; Sergio R Ojeda; Byung Ju Lee
Journal:  J Biol Chem       Date:  2010-06-10       Impact factor: 5.157

3.  Tissue-specific expression from a compound TATA-dependent and TATA-independent promoter.

Authors:  P A Garrity; B J Wold
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

4.  Partial purification and characterization of an 80-kDa transcription factor binding to bHLH motif in the rat p53 promoter.

Authors:  Minhyung Lee; Yong-beom Lim; Jong-sang Park
Journal:  Mol Biol Rep       Date:  2002-12       Impact factor: 2.316

5.  Overlap of the p53-responsive element and cAMP-responsive element in the enhancer of human T-cell leukemia virus type I.

Authors:  N Aoyama; T Nagase; T Sawazaki; G Mizuguchi; H Nakagoshi; J I Fujisawa; M Yoshida; S Ishii
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

6.  Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter.

Authors:  M C Blake; R C Jambou; A G Swick; J W Kahn; J C Azizkhan
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

7.  Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

Authors:  N Sugawa; A J Ekstrand; C D James; V P Collins
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

8.  Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster.

Authors:  J C Eissenberg; T C James; D M Foster-Hartnett; T Hartnett; V Ngan; S C Elgin
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

9.  Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice.

Authors:  E Danciger; C Mettling; M Vidal; R Morris; F Margolis
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

10.  Optimization of PCR conditions for amplification of GC-Rich EGFR promoter sequence.

Authors:  Jasmina Obradovic; Vladimir Jurisic; Natasa Tosic; Jasminka Mrdjanovic; Branislav Perin; Sonja Pavlovic; Natasa Djordjevic
Journal:  J Clin Lab Anal       Date:  2013-11       Impact factor: 2.352
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