Literature DB >> 3467839

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

R Derynck, D V Goeddel, A Ullrich, J U Gutterman, R D Williams, T S Bringman, W H Berger.   

Abstract

Human tumors and tumor cell lines were analyzed for the presence of mRNA coding for transforming growth factors alpha and beta (TGF-alpha and -beta) and the epidermal growth factor receptor. TGF-alpha mRNA was not detectable in hematopoietic tumor cell lines but was found in a variety of solid tumor cells, particularly carcinomas. Many of the tumors that contained TGF-alpha mRNA also expressed high levels of epidermal growth factor receptor mRNA. The concentration of TGF-alpha in the media of several tumor cell lines did not necessarily correlate with TGF-alpha mRNA levels, as a substantial fraction of TGF-alpha can remain cell associated. The levels of TGF-beta mRNA in tumor cell lines and tumor specimens were variable, but higher in tumors than in the adjacent normal tissues.

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Year:  1987        PMID： 3467839

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  208 in total

1.  Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.

Authors:  M Jost; T M Huggett; C Kari; U Rodeck
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2.  Parathyroid Hormone-related Protein in Breast Cancer Tissues: Relationship between Primary and Metastatic Sites.

Authors: 
Journal:  Breast Cancer       Date:  1994-07-30       Impact factor: 4.239

3.  Dietary fiber enhances a tumor suppressor signaling pathway in the gut.

Authors:  Khoa A Nguyen; Yanna Cao; Justin R Chen; Courtney M Townsend; Tien C Ko
Journal:  Ann Surg       Date:  2006-05       Impact factor: 12.969

4.  Proliferating cell nuclear antigen in oesophageal diseases; correlation with transforming growth factor alpha expression.

Authors:  J Jankowski; R McMenemin; C Yu; D Hopwood; K G Wormsley
Journal:  Gut       Date:  1992-05       Impact factor: 23.059

Review 5.  Monoclonal antibodies to epidermal growth factor receptors in studies of receptor structure and function.

Authors:  T Kawamoto; G H Sato; K Takahashi; M Nishi; S Taniguchi; J D Sato
Journal:  Cytotechnology       Date:  1990-05       Impact factor: 2.058

6.  Transforming growth factor-ßs as modulators of pericellular proteolytic events.

Authors:  J Keski-Oja; J Lohi; M Laiho
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

7.  Production of transforming growth factor alpha by hamster eosinophils.

Authors:  A Elovic; S J Galli; P F Weller; A L Chang; T Chiang; M Y Chou; R B Donoff; G T Gallagher; K Matossian; J McBride
Journal:  Am J Pathol       Date:  1990-12       Impact factor: 4.307

8.  Epidermal growth factor receptor gene expression and binding capacity in renal cell carcinoma, in relation to tumor stage, grade and DNA ploidy.

Authors:  B Ljungberg; M Gåfvels; J E Damber
Journal:  Urol Res       Date:  1994

9.  Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappaB.

Authors:  Y Sato; J Kato; R Takimoto; K Takada; Y Kawano; K Miyanishi; M Kobune; Y Sato; T Takayama; T Matunaga; Y Niitsu
Journal:  Gut       Date:  2006-03-31       Impact factor: 23.059

10.  Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells.

Authors:  T Oikawa; J Hitomi; A Kono; E Kaneko; K Yamaguchi
Journal:  Int J Pancreatol       Date:  1995-08
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