Kazutaka Nakashima1, Akiko Mizutou2, Sayaka Sakurai2. 1. Department of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan. urbandoc@med.kawasaki-m.ac.jp. 2. Department of General Surgery, Kawasaki Medical School General Medical Center, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.
Abstract
PURPOSE: To determine the reproducibility, accuracy, and quantitative values of the auto strain ratio system (ASRS)-a newly developed strain elastography-based program. MATERIALS AND METHODS: First, the accuracy of ASRS was verified using a breast phantom. A prospective clinical study was then performed in patients. Two hundred and one women (mean age 52.4 years ± SD 14.5) with 232 breast lesions (177 benign and 55 malignant) were enrolled in this study. We assessed the correlation between ASRS and manual strain ratio (MSR), calculating the diagnostic performance to determine the cut-off. The area under the receiver operating characteristic curve (AUC) was calculated. RESULTS: ASRS was strongly correlated with the subtle differences in phantom stiffness (R = 0.87). In the clinical study, there was a significant correlation between MSR and ASRS with R = 0.79 (P < 0.001). ASRS (cut-off = 3.9) had a sensitivity of 81.8%, specificity of 88.7%, accuracy of 87.1%, positive predictive value of 69.2%, and negative predictive value of 94%. The AUC of ASRS was 0.89. CONCLUSION: The findings from this study have demonstrated that it is possible to quantify strain elastography and control its accuracy. ASRS is expected to contribute to the standardization of breast elastography.
PURPOSE: To determine the reproducibility, accuracy, and quantitative values of the auto strain ratio system (ASRS)-a newly developed strain elastography-based program. MATERIALS AND METHODS: First, the accuracy of ASRS was verified using a breast phantom. A prospective clinical study was then performed in patients. Two hundred and one women (mean age 52.4 years ± SD 14.5) with 232 breast lesions (177 benign and 55 malignant) were enrolled in this study. We assessed the correlation between ASRS and manual strain ratio (MSR), calculating the diagnostic performance to determine the cut-off. The area under the receiver operating characteristic curve (AUC) was calculated. RESULTS: ASRS was strongly correlated with the subtle differences in phantom stiffness (R = 0.87). In the clinical study, there was a significant correlation between MSR and ASRS with R = 0.79 (P < 0.001). ASRS (cut-off = 3.9) had a sensitivity of 81.8%, specificity of 88.7%, accuracy of 87.1%, positive predictive value of 69.2%, and negative predictive value of 94%. The AUC of ASRS was 0.89. CONCLUSION: The findings from this study have demonstrated that it is possible to quantify strain elastography and control its accuracy. ASRS is expected to contribute to the standardization of breast elastography.
Entities:
Keywords:
Auto frame selection; Auto strain ratio system; Automatic setting of ROIs; Strain elastography; Strain ratio
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