Literature DB >> 2895014

Alpha-adrenoceptor blocking action of hymenin, a novel marine alkaloid.

J Kobayashi1, H Nakamura, Y Ohizumi.   

Abstract

In the rabbit isolated aorta, hymenin (10(-6) M), a novel marine alkaloid, caused a parallel rightward shift of the dose-response curve for norepinephrine without affecting that for histamine or KCl, suggesting that hymenin is a competitive antagonist of alpha-adrenoceptors in vascular smooth muscles.

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Year:  1988        PMID： 2895014     DOI： 10.1007/bf01960260

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

Authors:  J M VAN ROSSUM
Journal:  Arch Int Pharmacodyn Ther       Date:  1963

2.  Bromo-eudistomin D, a novel inducer of calcium release from fragmented sarcoplasmic reticulum that causes contractions of skinned muscle fibers.

Authors:  Y Nakamura; J Kobayashi; J Gilmore; M Mascal; K L Rinehart; H Nakamura; Y Ohizumi
Journal:  J Biol Chem       Date:  1986-03-25       Impact factor: 5.157

3.  Specific inhibition of [3H] saxitoxin binding to skeletal muscle sodium channels by geographutoxin II, a polypeptide channel blocker.

Authors:  Y Ohizumi; H Nakamura; J Kobayashi; W A Catterall
Journal:  J Biol Chem       Date:  1986-05-15       Impact factor: 5.157

4.  A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp.

Authors:  J Kobayashi; Y Ohizumi; H Nakamura; Y Hirata
Journal:  Experientia       Date:  1986-10-15

5.  Hymenin, a novel alpha-adrenoreceptor blocking agent from the Okinawan marine sponge Hymeniacidon sp.

Authors:  J Kobayashi; Y Ohizumi; H Nakamura; Y Hirata; K Wakamatsu; T Miyazawa
Journal:  Experientia       Date:  1986-09-15

Review 6.  Chemicals as tools in the study of excitable membranes.

Authors:  T Narahashi
Journal:  Physiol Rev       Date:  1974-10       Impact factor: 37.312

7.  Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle.

Authors:  Y Ohizumi; A Kajiwara; H Nakamura; J Kobayashi
Journal:  J Pharm Pharmacol       Date:  1984-11       Impact factor: 3.765

8.  Hypotensive effects of N,N-din-n-propylodopamine in the anesthetized dog: comparison with sodium nitroprusside.

Authors:  W H Fennell; J D Kohli; L I Goldberg
Journal:  J Cardiovasc Pharmacol       Date:  1980       Impact factor: 3.105

9.  Ca2+ channel activating function of maitotoxin, the most potent marine toxin known, in clonal rat pheochromocytoma cells.

Authors:  M Takahashi; M Tatsumi; Y Ohizumi; T Yasumoto
Journal:  J Biol Chem       Date:  1983-09-25       Impact factor: 5.157

10.  Contractile response of the rabbit aorta to maitotoxin, the most potent marine toxin.

Authors:  Y Ohizumi; T Yasumoto
Journal:  J Physiol       Date:  1983-04       Impact factor: 5.182
  10 in total
  3 in total

Review 1.  Recent progress in neuroactive marine natural products.

Authors:  Ryuichi Sakai; Geoffrey T Swanson
Journal:  Nat Prod Rep       Date:  2014-01-17       Impact factor: 13.423

2.  Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges.

Authors:  R Rosa; W Silva; G Escalona de Motta; A D Rodríguez; J J Morales; M Ortiz
Journal:  Experientia       Date:  1992-09-15

3.  Symbioramide, a novel Ca2+-ATPase activator from the cultured dinoflagellate Symbiodinium sp.

Authors:  J Kobayashi; M Ishibashi; H Nakamura; Y Hirata; T Yamasu; T Sasaki; Y Ohizumi
Journal:  Experientia       Date:  1988-09-15
  3 in total

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