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Literature DB >> 2875898

Hymenin, a novel alpha-adrenoreceptor blocking agent from the Okinawan marine sponge Hymeniacidon sp.

J Kobayashi, Y Ohizumi, H Nakamura, Y Hirata, K Wakamatsu, T Miyazawa.

Abstract

A novel bromine-containing alkaloid, hymenin, has been isolated from the Okinawan marine sponge Hymeniacidon sp. as a potent alpha-adrenoceptor blocking agent and its structure determined to be 1 on the basis of the spectral data.

Entities: Chemical

Mesh：

Substances：

Year: 1986 PMID： 2875898 DOI： 10.1007/bf01940735

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

5 in total

1. Metabolism in porifera. III. Chemical patterns and the classification of the Desmospongiae.

Authors: G Cimino; S de Stefano; L Minale; G Sodano
Journal: Comp Biochem Physiol B Date: 1975-02-15

2. Ca-antagonistic substance from soft coral of the genus Sarcophyton.

Authors: J Kobayashi; Y Ohizumi; H Nakamura; T Yamakado; T Matsuzaki; Y Hirata
Journal: Experientia Date: 1983-01-15

3. Pharmacological study on the venom of the marine snail Conus textile.

Authors: J Kobayashi; Y Ohizumi; H Nakamura; Y Hirata
Journal: Toxicon Date: 1981 Impact factor: 3.033

4. Marine natural products: pyrrololactams from several sponges.

Authors: F J Schmitz; S P Gunasekera; V Lakshmi; L M Tillekeratne
Journal: J Nat Prod Date: 1985 Jan-Feb Impact factor: 4.050

5. Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle.

Authors: Y Ohizumi; A Kajiwara; H Nakamura; J Kobayashi
Journal: J Pharm Pharmacol Date: 1984-11 Impact factor: 3.765

5 in total

4 in total

Hymenin, a novel alpha-adrenoreceptor blocking agent from the Okinawan marine sponge Hymeniacidon sp.

1. Metabolism in porifera. III. Chemical patterns and the classification of the Desmospongiae.

2. Ca-antagonistic substance from soft coral of the genus Sarcophyton.

3. Pharmacological study on the venom of the marine snail Conus textile.

4. Marine natural products: pyrrololactams from several sponges.

5. Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle.

1. A potent actomyosin ATPase activator from the Okinawan marine sponge Agelas cf. nemoechinata.

2. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp.

3. Alpha-adrenoceptor blocking action of hymenin, a novel marine alkaloid.

4. Bromopyrrole Alkaloids with the Inhibitory Effects against the Biofilm Formation of Gram Negative Bacteria.