Literature DB >> 1397186

Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges.

R Rosa1, W Silva, G Escalona de Motta, A D Rodríguez, J J Morales, M Ortiz.   

Abstract

In a search for potential target sites for C11N5 compounds obtained from marine sponges of the genus Agelas we evaluated their interaction with muscarinic acetylcholine receptors from rat brain membranes. In competition experiments with 3H-QNB these compounds displayed the following rank order of potency: sceptrin greater than oroidin greater than or equal to dibromosceptrin greater than or equal to clathrodin. Sceptrin (50 microM) was shown to be a competitive inhibitor of 3H-QNB binding as revealed by Scatchard analysis. The results demonstrate the ability of these compounds to interact with multiple target molecules in the micromolar range.

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Year:  1992        PMID： 1397186     DOI： 10.1007/bf02118426

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  A potent actomyosin ATPase activator from the Okinawan marine sponge Agelas cf. nemoechinata.

Authors:  J Kobayashi; M Tsuda; Y Ohizumi
Journal:  Experientia       Date:  1991-03-15

2.  Potential-dependent action of Anemonia sulcata toxins III and IV on sodium channels in crayfish giant axons.

Authors:  A Warashina; Z Y Jiang; T Ogura
Journal:  Pflugers Arch       Date:  1988-01       Impact factor: 3.657

3.  A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp.

Authors:  J Kobayashi; Y Ohizumi; H Nakamura; Y Hirata
Journal:  Experientia       Date:  1986-10-15

4.  Alpha-adrenoceptor blocking action of hymenin, a novel marine alkaloid.

Authors:  J Kobayashi; H Nakamura; Y Ohizumi
Journal:  Experientia       Date:  1988-01-15

5.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

Authors:  Y Cheng; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1973-12-01       Impact factor: 5.858

6.  Neurotoxin binding to receptor sites associated with voltage-sensitive sodium channels in intact, lysed, and detergent-solubilized brain membranes.

Authors:  W A Catterall; C S Morrow; R P Hartshorne
Journal:  J Biol Chem       Date:  1979-11-25       Impact factor: 5.157

7.  Synthesis and biological activity of six monosubstituted analogs of a sea anemone polypeptide neurotoxin.

Authors:  M W Pennington; W R Kem; B M Dunn
Journal:  Pept Res       Date:  1990 Sep-Oct

8.  Purification and pharmacological properties of eight sea anemone toxins from Anemonia sulcata, Anthopleura xanthogrammica, Stoichactis giganteus, and Actinodendron plumosum.

Authors:  H Schweitz; J P Vincent; J Barhanin; C Frelin; G Linden; M Hugues; M Lazdunski
Journal:  Biochemistry       Date:  1981-09-01       Impact factor: 3.162

9.  The sodium channel from rat brain. Purification and subunit composition.

Authors:  R P Hartshorne; W A Catterall
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

10.  Evidence for the presence of muscarinic acetylcholine receptors in bovine brain coated vesicles.

Authors:  W I Silva; A Andres; W Schook; S Puszkin
Journal:  J Biol Chem       Date:  1986-11-05       Impact factor: 5.157
  10 in total
  6 in total

Review 1.  Bioactive cyclobutane-containing alkaloids.

Authors:  Valery M Dembitsky
Journal:  J Nat Med       Date:  2007-09-05       Impact factor: 2.343

2.  Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines.

Authors:  Ian B Seiple; Shun Su; Ian S Young; Akifumi Nakamura; Junichiro Yamaguchi; Lars Jørgensen; Rodrigo A Rodriguez; Daniel P O'Malley; Tanja Gaich; Matthias Köck; Phil S Baran
Journal:  J Am Chem Soc       Date:  2011-08-23       Impact factor: 15.419

3.  In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the Sponge Agelas dilatata, against Pseudomonas aeruginosa.

Authors:  Dawrin Pech-Puch; Mar Pérez-Povedano; Marta Martinez-Guitian; Cristina Lasarte-Monterrubio; Juan Carlos Vázquez-Ucha; Germán Bou; Jaime Rodríguez; Alejandro Beceiro; Carlos Jimenez
Journal:  Mar Drugs       Date:  2020-06-23       Impact factor: 5.118

4.  Cyclobutane-containing alkaloids: origin, synthesis, and biological activities.

Authors:  Anastasia Sergeiko; Vladimir V Poroikov; Lumir O Hanus; Valery M Dembitsky
Journal:  Open Med Chem J       Date:  2008-04-15

Review 5.  A submarine journey: the pyrrole-imidazole alkaloids.

Authors:  Barbara Forte; Beatrice Malgesini; Claudia Piutti; Francesca Quartieri; Alessandra Scolaro; Gianluca Papeo
Journal:  Mar Drugs       Date:  2009-11-27       Impact factor: 5.118

6.  Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines.

Authors:  Angel Cipres; Daniel P O'Malley; Ke Li; Darren Finlay; Phil S Baran; Kristiina Vuori
Journal:  ACS Chem Biol       Date:  2010-02-19       Impact factor: 5.100
  6 in total

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