| Literature DB >> 6150989 |
Y Ohizumi, A Kajiwara, H Nakamura, J Kobayashi.
Abstract
In the rabbit isolated aorta and renal artery, aaptamine (3 X 10(-5)M), a novel heteroaromatic substance isolated from a sea sponge Aaptos aaptos produced a parallel, rightward shift of the dose-response curve for noradrenaline, whereas that for histamine or KCl was not affected. But, the derivatives of aaptamine, demethylaaptamine, demethyloxyaaptamine, dihydroaaptamine and dihydrodemethylaaptamine at concentrations of 10(-5) to 10(-4)M had no effect on the dose-response curve for noradrenaline. These results suggest that aaptamine is a competitive antagonist of alpha-adrenoceptors in vascular smooth muscles.Entities:
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Year: 1984 PMID： 6150989 DOI： 10.1111/j.2042-7158.1984.tb04876.x
Source DB: PubMed Journal: J Pharm Pharmacol ISSN： 0022-3573 Impact factor: 3.765