Literature DB >> 28926557

Target class drug discovery.

Kimberly D Barnash1, Lindsey I James1, Stephen V Frye1.   

Abstract

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Year:  2017        PMID： 28926557      PMCID： PMC5973815          DOI： 10.1038/nchembio.2473

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  25 in total

1.  The ins and outs of selective kinase inhibitor development.

Authors:  Susanne Müller; Apirat Chaikuad; Nathanael S Gray; Stefan Knapp
Journal:  Nat Chem Biol       Date:  2015-11       Impact factor: 15.040

2.  Small-molecule kinase inhibitors: an analysis of FDA-approved drugs.

Authors:  Peng Wu; Thomas E Nielsen; Mads H Clausen
Journal:  Drug Discov Today       Date:  2015-07-23       Impact factor: 7.851

Review 3.  The cancer epigenome--components and functional correlates.

Authors:  Angela H Ting; Kelly M McGarvey; Stephen B Baylin
Journal:  Genes Dev       Date:  2006-12-01       Impact factor: 11.361

4.  Recognizing and exploiting differences between RNAi and small-molecule inhibitors.

Authors:  William A Weiss; Stephen S Taylor; Kevan M Shokat
Journal:  Nat Chem Biol       Date:  2007-12       Impact factor: 15.040

5.  Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Authors:  Daniel Martinez Molina; Rozbeh Jafari; Marina Ignatushchenko; Takahiro Seki; E Andreas Larsson; Chen Dan; Lekshmy Sreekumar; Yihai Cao; Pär Nordlund
Journal:  Science       Date:  2013-07-05       Impact factor: 47.728

6.  Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing.

Authors:  Kimberly D Barnash; Kelsey N Lamb; Jacob I Stuckey; Jacqueline L Norris; Stephanie H Cholensky; Dmitri B Kireev; Stephen V Frye; Lindsey I James
Journal:  ACS Chem Biol       Date:  2016-07-14       Impact factor: 5.100

Review 7.  Targeting bromodomains: epigenetic readers of lysine acetylation.

Authors:  Panagis Filippakopoulos; Stefan Knapp
Journal:  Nat Rev Drug Discov       Date:  2014-04-22       Impact factor: 84.694

8.  In situ kinase profiling reveals functionally relevant properties of native kinases.

Authors:  Matthew P Patricelli; Tyzoon K Nomanbhoy; Jiangyue Wu; Heidi Brown; David Zhou; Jianming Zhang; Subadhra Jagannathan; Arwin Aban; Eric Okerberg; Chris Herring; Brian Nordin; Helge Weissig; Qingkai Yang; Jiing-Dwan Lee; Nathanael S Gray; John W Kozarich
Journal:  Chem Biol       Date:  2011-06-24

Review 9.  Chemical probes for methyl lysine reader domains.

Authors:  Lindsey I James; Stephen V Frye
Journal:  Curr Opin Chem Biol       Date:  2016-06-25       Impact factor: 8.822

10.  Drug discovery toward antagonists of methyl-lysine binding proteins.

Authors:  J Martin Herold; Lindsey A Ingerman; Cen Gao; Stephen V Frye
Journal:  Curr Chem Genomics       Date:  2011-08-22
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  11 in total

1.  A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.

Authors:  Jarod M Waybright; Sarah E Clinkscales; Kimberly D Barnash; Gabrielle R Budziszewski; Justin M Rectenwald; Anna M Chiarella; Jacqueline L Norris-Drouin; Stephanie H Cholensky; Kenneth H Pearce; Laura E Herring; Robert K McGinty; Nathaniel A Hathaway; Lindsey I James
Journal:  ACS Chem Biol       Date:  2021-08-20       Impact factor: 4.634

2.  Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology.

Authors:  Chenxiao Da; Dehui Zhang; Michael Stashko; Eleana Vasileiadi; Rebecca E Parker; Katherine A Minson; Madeline G Huey; Justus M Huelse; Debra Hunter; Thomas S K Gilbert; Jacqueline Norris-Drouin; Michael Miley; Laura E Herring; Lee M Graves; Deborah DeRyckere; H Shelton Earp; Douglas K Graham; Stephen V Frye; Xiaodong Wang; Dmitri Kireev
Journal:  J Am Chem Soc       Date:  2019-09-20       Impact factor: 15.419

Review 3.  RNA-modifying proteins as anticancer drug targets.

Authors:  P Ann Boriack-Sjodin; Scott Ribich; Robert A Copeland
Journal:  Nat Rev Drug Discov       Date:  2018-05-18       Impact factor: 84.694

4.  Getting a handle on chemical probes of chomatin readers.

Authors:  Jarod M Waybright; Lindsey I James
Journal:  Future Med Chem       Date:  2020-01-10       Impact factor: 3.808

5.  A General TR-FRET Assay Platform for High-Throughput Screening and Characterizing Inhibitors of Methyl-Lysine Reader Proteins.

Authors:  Justin M Rectenwald; P Brian Hardy; Jacqueline L Norris-Drouin; Stephanie H Cholensky; Lindsey I James; Stephen V Frye; Kenneth H Pearce
Journal:  SLAS Discov       Date:  2019-04-24       Impact factor: 3.341

Review 6.  Inositol phosphate kinases: Expanding the biological significance of the universal core of the protein kinase fold.

Authors:  Stephen B Shears; Huanchen Wang
Journal:  Adv Biol Regul       Date:  2018-10-27

7.  Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors.

Authors:  Ana C Puhl-Rubio; Michael A Stashko; Huanchen Wang; P Brian Hardy; Vikas Tyagi; Bing Li; Xiaodong Wang; Dmitri Kireev; Henning J Jessen; Stephen V Frye; Stephen B Shears; Kenneth H Pearce
Journal:  SLAS Discov       Date:  2018-05-29       Impact factor: 3.341

8.  A "Target Class" Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels.

Authors:  David McCoull; Emma Ococks; Jonathan M Large; David C Tickle; Alistair Mathie; Jeffrey Jerman; Paul D Wright
Journal:  SLAS Discov       Date:  2020-12-29       Impact factor: 3.341

9.  Target 2035 - update on the quest for a probe for every protein.

Authors:  Susanne Müller; Suzanne Ackloo; Arij Al Chawaf; Bissan Al-Lazikani; Albert Antolin; Jonathan B Baell; Hartmut Beck; Shaunna Beedie; Ulrich A K Betz; Gustavo Arruda Bezerra; Paul E Brennan; David Brown; Peter J Brown; Alex N Bullock; Adrian J Carter; Apirat Chaikuad; Mathilde Chaineau; Alessio Ciulli; Ian Collins; Jan Dreher; David Drewry; Kristina Edfeldt; Aled M Edwards; Ursula Egner; Stephen V Frye; Stephen M Fuchs; Matthew D Hall; Ingo V Hartung; Alexander Hillisch; Stephen H Hitchcock; Evert Homan; Natarajan Kannan; James R Kiefer; Stefan Knapp; Milka Kostic; Stefan Kubicek; Andrew R Leach; Sven Lindemann; Brian D Marsden; Hisanori Matsui; Jordan L Meier; Daniel Merk; Maurice Michel; Maxwell R Morgan; Anke Mueller-Fahrnow; Dafydd R Owen; Benjamin G Perry; Saul H Rosenberg; Kumar Singh Saikatendu; Matthieu Schapira; Cora Scholten; Sujata Sharma; Anton Simeonov; Michael Sundström; Giulio Superti-Furga; Matthew H Todd; Claudia Tredup; Masoud Vedadi; Frank von Delft; Timothy M Willson; Georg E Winter; Paul Workman; Cheryl H Arrowsmith
Journal:  RSC Med Chem       Date:  2021-12-03

10.  Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins.

Authors:  Justin M Rectenwald; Shiva Krishna Reddy Guduru; Zhao Dang; Leonard B Collins; Yi-En Liao; Jacqueline L Norris-Drouin; Stephanie H Cholensky; Kyle W Kaufmann; Scott M Hammond; Dmitri B Kireev; Stephen V Frye; Kenneth H Pearce
Journal:  Molecules       Date:  2020-02-22       Impact factor: 4.411
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