Literature DB >> 26485069

The ins and outs of selective kinase inhibitor development.

Susanne Müller1, Apirat Chaikuad1, Nathanael S Gray2, Stefan Knapp3.   

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Year:  2015        PMID： 26485069     DOI： 10.1038/nchembio.1938

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  25 in total

1.  Comprehensive analysis of kinase inhibitor selectivity.

Authors:  Mindy I Davis; Jeremy P Hunt; Sanna Herrgard; Pietro Ciceri; Lisa M Wodicka; Gabriel Pallares; Michael Hocker; Daniel K Treiber; Patrick P Zarrinkar
Journal:  Nat Biotechnol       Date:  2011-10-30       Impact factor: 54.908

2.  Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase.

Authors:  D R Knighton; J H Zheng; L F Ten Eyck; N H Xuong; S S Taylor; J M Sowadski
Journal:  Science       Date:  1991-07-26       Impact factor: 47.728

3.  Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.

Authors:  Valerie Hindie; Adriana Stroba; Hua Zhang; Laura A Lopez-Garcia; Leila Idrissova; Stefan Zeuzem; Daniel Hirschberg; Francis Schaeffer; Thomas J D Jørgensen; Matthias Engel; Pedro M Alzari; Ricardo M Biondi
Journal:  Nat Chem Biol       Date:  2009-08-30       Impact factor: 15.040

4.  Understanding the impact of the P-loop conformation on kinase selectivity.

Authors:  Cristiano R W Guimarães; Brajesh K Rai; Michael J Munchhof; Shenping Liu; Jian Wang; Samit K Bhattacharya; Leonard Buckbinder
Journal:  J Chem Inf Model       Date:  2011-05-24       Impact factor: 4.956

Review 5.  Developing irreversible inhibitors of the protein kinase cysteinome.

Authors:  Qingsong Liu; Yogesh Sabnis; Zheng Zhao; Tinghu Zhang; Sara J Buhrlage; Lyn H Jones; Nathanael S Gray
Journal:  Chem Biol       Date:  2013-02-21

Review 6.  Recently targeted kinases and their inhibitors-the path to clinical trials.

Authors:  Stefan Knapp; Michael Sundström
Journal:  Curr Opin Pharmacol       Date:  2014-08-09       Impact factor: 5.547

7.  Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).

Authors:  Jeffrey M Axten; Jesús R Medina; Yanhong Feng; Arthur Shu; Stuart P Romeril; Seth W Grant; William Hoi Hong Li; Dirk A Heerding; Elisabeth Minthorn; Thomas Mencken; Charity Atkins; Qi Liu; Sridhar Rabindran; Rakesh Kumar; Xuan Hong; Aaron Goetz; Thomas Stanley; J David Taylor; Scott D Sigethy; Ginger H Tomberlin; Annie M Hassell; Kirsten M Kahler; Lisa M Shewchuk; Robert T Gampe
Journal:  J Med Chem       Date:  2012-08-08       Impact factor: 7.446

8.  Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.

Authors:  Melissa V Gammons; Oleg Fedorov; David Ivison; Chunyun Du; Tamsyn Clark; Claire Hopkins; Masatoshi Hagiwara; Andrew D Dick; Russell Cox; Steven J Harper; Jules C Hancox; Stefan Knapp; David O Bates
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-09-05       Impact factor: 4.799

9.  Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.

Authors:  T Schindler; W Bornmann; P Pellicena; W T Miller; B Clarkson; J Kuriyan
Journal:  Science       Date:  2000-09-15       Impact factor: 47.728

10.  Dual kinase-bromodomain inhibitors for rationally designed polypharmacology.

Authors:  Pietro Ciceri; Susanne Müller; Alison O'Mahony; Oleg Fedorov; Panagis Filippakopoulos; Jeremy P Hunt; Elisabeth A Lasater; Gabriel Pallares; Sarah Picaud; Christopher Wells; Sarah Martin; Lisa M Wodicka; Neil P Shah; Daniel K Treiber; Stefan Knapp
Journal:  Nat Chem Biol       Date:  2014-03-02       Impact factor: 15.040
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  64 in total

1.  A Chemical Probe Strategy for Interrogating Inhibitor Selectivity Across the MEK Kinase Family.

Authors:  Kristine K Deibler; Rama K Mishra; Matthew R Clutter; Aleksandar Antanasijevic; Raymond Bergan; Michael Caffrey; Karl A Scheidt
Journal:  ACS Chem Biol       Date:  2017-03-20       Impact factor: 5.100

2.  Effects of rigidity on the selectivity of protein kinase inhibitors.

Authors:  Amir Assadieskandar; Caiqun Yu; Pierre Maisonneuve; Xu Liu; Ying-Chu Chen; G K Surya Prakash; Igor Kurinov; Frank Sicheri; Chao Zhang
Journal:  Eur J Med Chem       Date:  2018-01-31       Impact factor: 6.514

Review 3.  Targeting kinase signaling pathways with constrained peptide scaffolds.

Authors:  Laura E Hanold; Melody D Fulton; Eileen J Kennedy
Journal:  Pharmacol Ther       Date:  2017-02-07       Impact factor: 12.310

4.  Delineation of Polypharmacology across the Human Structural Kinome Using a Functional Site Interaction Fingerprint Approach.

Authors:  Zheng Zhao; Li Xie; Lei Xie; Philip E Bourne
Journal:  J Med Chem       Date:  2016-03-17       Impact factor: 7.446

5.  Assessing Lysine and Cysteine Reactivities for Designing Targeted Covalent Kinase Inhibitors.

Authors:  Ruibin Liu; Zhi Yue; Cheng-Chieh Tsai; Jana Shen
Journal:  J Am Chem Soc       Date:  2019-04-16       Impact factor: 15.419

6.  How Electrostatic Coupling Enables Conformational Plasticity in a Tyrosine Kinase.

Authors:  Cheng-Chieh Tsai; Zhi Yue; Jana Shen
Journal:  J Am Chem Soc       Date:  2019-09-13       Impact factor: 15.419

7.  A Conserved Allosteric Pathway in Tyrosine Kinase Regulation.

Authors:  William M Marsiglia; Joseph Katigbak; Sijin Zheng; Moosa Mohammadi; Yingkai Zhang; Nathaniel J Traaseth
Journal:  Structure       Date:  2019-06-13       Impact factor: 5.006

Review 8.  Kinase inhibitors: the road ahead.

Authors:  Fleur M Ferguson; Nathanael S Gray
Journal:  Nat Rev Drug Discov       Date:  2018-03-16       Impact factor: 84.694

9.  DeepKinZero: zero-shot learning for predicting kinase-phosphosite associations involving understudied kinases.

Authors:  Iman Deznabi; Busra Arabaci; Mehmet Koyutürk; Oznur Tastan
Journal:  Bioinformatics       Date:  2020-06-01       Impact factor: 6.937

10.  A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.

Authors:  Alfredo Picado; Apirat Chaikuad; Carrow I Wells; Safal Shrestha; William J Zuercher; Julie E Pickett; Frank E Kwarcinski; Parvathi Sinha; Chandi S de Silva; Reena Zutshi; Shubin Liu; Natarajan Kannan; Stefan Knapp; David H Drewry; Timothy M Willson
Journal:  J Med Chem       Date:  2020-11-20       Impact factor: 7.446
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