Literature DB >> 28901329

Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.

Toshihiko Nogawa1, Naoki Kato2, Takeshi Shimizu1, Akiko Okano1, Yushi Futamura1, Shunji Takahashi2, Hiroyuki Osada1.   

Abstract

Two new decaline metabolites, wakodecalines A and B, were isolated from a fungus, Pyrenochaetopsis sp. RK10-F058, by screening for structurally unique metabolites using LC/MS analysis. Their structures were determined on the basis of NMR and mass spectrometric measurements. The absolute structures were confirmed by a combination of chemical methods including chemical degradation, a modified Mosher's method and Marfey's method, and comparison of the experimental electronic CD (ECD) spectrum with calculated one. Both compounds had a cyclopentanone-fused decaline skeleton and an N-methylated amino acid moiety derived from a serine. They showed moderate antimalarial activity against the Plasmodium falciparum 3D7 strain.The Journal of Antibiotics advance online publication, 13 September 2017; doi:10.1038/ja.2017.103.

Entities:  

Year:  2017        PMID： 28901329     DOI： 10.1038/ja.2017.103

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  17 in total

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Authors:  H Osada; H Koshino; K Isono; H Takahashi; G Kawanishi
Journal:  J Antibiot (Tokyo)       Date:  1991-02       Impact factor: 2.649

Review 2.  Natural Products as Sources of New Drugs from 1981 to 2014.

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Review 3.  Bioactive microbial metabolites.

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Review 4.  Tetramic and tetronic acids: an update on new derivatives and biological aspects.

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5.  RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening.

Authors:  Chung Liang Lim; Toshihiko Nogawa; Masakazu Uramoto; Akiko Okano; Yayoi Hongo; Takemichi Nakamura; Hiroyuki Koshino; Shunji Takahashi; Darah Ibrahim; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2014-02-05       Impact factor: 2.649

6.  Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.

Authors:  Hideaki Kakeya; Rie Onose; Hiroyuki Koshino; Arika Yoshida; Kimiko Kobayashi; Shun-Ichiro Kageyama; Hiroyuki Osada
Journal:  J Am Chem Soc       Date:  2002-04-10       Impact factor: 15.419

7.  Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326.

Authors:  Jae-Hyuk Jang; Yukihiro Asami; Jun-Pil Jang; Sun-Ok Kim; Dong Oh Moon; Kee-Sun Shin; Daisuke Hashizume; Makoto Muroi; Tamio Saito; Hyuncheol Oh; Bo Yeon Kim; Hiroyuki Osada; Jong Seog Ahn
Journal:  J Am Chem Soc       Date:  2011-04-18       Impact factor: 15.419

8.  Pyrrolizilactone, a new pyrrolizidinone metabolite produced by a fungus.

Authors:  Toshihiko Nogawa; Makoto Kawatani; Masakazu Uramoto; Akiko Okano; Harumi Aono; Yushi Futamura; Hiroyuki Koshino; Shunji Takahashi; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2013-05-29       Impact factor: 2.649

Review 9.  Circular dichroism calculation for natural products.

Authors:  Alfarius Eko Nugroho; Hiroshi Morita
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10.  Bioactive natural products from fungicolous Hawaiian isolates: secondary metabolites from a Phialemoniopsis sp.

Authors:  Amninder Kaur; Kristina D Rogers; Dale E Swenson; Patrick F Dowd; Donald T Wicklow; James B Gloer
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  6 in total

Review 1.  Antiplasmodial natural products: an update.

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Review 2.  Recent advances in the chemo-biological characterization of decalin natural products and unraveling of the workings of Diels-Alderases.

Authors:  Kenji Watanabe; Michio Sato; Hiroyuki Osada
Journal:  Fungal Biol Biotechnol       Date:  2022-04-29

3.  Pyrenosetin D, a New Pentacyclic Decalinoyltetramic Acid Derivative from the Algicolous Fungus Pyrenochaetopsis sp. FVE-087.

Authors:  Bicheng Fan; Pradeep Dewapriya; Fengjie Li; Laura Grauso; Martina Blümel; Alfonso Mangoni; Deniz Tasdemir
Journal:  Mar Drugs       Date:  2020-05-26       Impact factor: 5.118

4.  Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12.

Authors:  Ziling Mao; Weixuan Wang; Ruixue Su; Gan Gu; Zhi Long Liu; Daowan Lai; Ligang Zhou
Journal:  Molecules       Date:  2019-12-27       Impact factor: 4.411

5.  Pyrenosetins A-C, New Decalinoylspirotetramic Acid Derivatives Isolated by Bioactivity-Based Molecular Networking from the Seaweed-Derived Fungus Pyrenochaetopsis sp. FVE-001.

Authors:  Bicheng Fan; Pradeep Dewapriya; Fengjie Li; Martina Blümel; Deniz Tasdemir
Journal:  Mar Drugs       Date:  2020-01-11       Impact factor: 5.118

6.  Application of Feature-Based Molecular Networking for Comparative Metabolomics and Targeted Isolation of Stereoisomers from Algicolous Fungi.

Authors:  Bicheng Fan; Laura Grauso; Fengjie Li; Silvia Scarpato; Alfonso Mangoni; Deniz Tasdemir
Journal:  Mar Drugs       Date:  2022-03-16       Impact factor: 5.118
  6 in total

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