Literature DB >> 11929225

Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.

Hideaki Kakeya1, Rie Onose, Hiroyuki Koshino, Arika Yoshida, Kimiko Kobayashi, Shun-Ichiro Kageyama, Hiroyuki Osada.   

Abstract

A unique pentaketide dimer structure of a novel fungal metabolite with antiangiogenic activity, designated as epoxyquinol A (1), was determined on the basis of NMR spectral data as well as the X-ray crystallographic analysis. 1 inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 3 mug/mL).

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Year:  2002        PMID: 11929225     DOI: 10.1021/ja0127279

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  5 in total

1.  RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis.

Authors:  Hideaki Kakeya; Daisuke Kaida; Hiromi Sekiya; Koji Nagai; Minoru Yoshida; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2015-09-09       Impact factor: 2.649

2.  Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.

Authors:  Toshihiko Nogawa; Naoki Kato; Takeshi Shimizu; Akiko Okano; Yushi Futamura; Shunji Takahashi; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2017-09-13       Impact factor: 2.649

3.  Iron salt-promoted oxidation of steroidal phenols by m-chloroperbenzoic acid: a route to possible antitumor agents.

Authors:  Tatjana J Kop; Nataša Terzić-Jovanović; Željko Žižak; Bogdan A Šolaja; Dragana R Milić
Journal:  RSC Adv       Date:  2022-07-18       Impact factor: 4.036

4.  Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation.

Authors:  Yukihiro Asami; Hideaki Kakeya; Yusuke Komi; Soichi Kojima; Kiyohiro Nishikawa; Kristin Beebe; Len Neckers; Hiroyuki Osada
Journal:  Cancer Sci       Date:  2008-07-10       Impact factor: 6.716

5.  Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities.

Authors:  Jun-Pil Jang; Hye Jin Jung; Jang Mi Han; Narae Jung; Yonghyo Kim; Ho Jeong Kwon; Sung-Kyun Ko; Nak-Kyun Soung; Jae-Hyuk Jang; Jong Seog Ahn
Journal:  PLoS One       Date:  2017-09-26       Impact factor: 3.240

  5 in total

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