Literature DB >> 24496142

RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening.

Chung Liang Lim1, Toshihiko Nogawa2, Masakazu Uramoto3, Akiko Okano2, Yayoi Hongo4, Takemichi Nakamura4, Hiroyuki Koshino4, Shunji Takahashi5, Darah Ibrahim6, Hiroyuki Osada5.   

Abstract

Two novel quinomycin derivatives, RK-1355A (1) and B (2), and one known quinomycin derivative, UK-63,598 (3), were isolated from a microbial metabolites fraction library of Streptomyces sp. RK88-1355 based on Natural Products Plot screening. The structural elucidation of 1 and 2 was established through two-dimensional NMR and mass spectrometric measurements. They belong to a class of quinomycin antibiotics family having 3-hydroxyquinaldic acid and a sulfoxide moiety. They are the first examples for natural products as a quinoline type quinomycin having a sulfoxide on the intramolecular cross-linkage. They showed potent antiproliferative activities against various cancer cell lines and they were also found to exhibit moderate antibacterial activity.

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Year:  2014        PMID： 24496142     DOI： 10.1038/ja.2013.144

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

1.  Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library.

Authors:  Chung Liang Lim; Toshihiko Nogawa; Akiko Okano; Yushi Futamura; Makoto Kawatani; Shunji Takahashi; Darah Ibrahim; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2015-12-09       Impact factor: 2.649

2.  RK-270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270.

Authors:  Jun-Pil Jang; Toshihiko Nogawa; Masakazu Uramoto; Akiko Okano; Yushi Futamura; Takeshi Shimizu; Shunji Takahashi; Jae-Hyuk Jang; Jong Seog Ahn; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2014-10-15       Impact factor: 2.649

3.  Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.

Authors:  Toshihiko Nogawa; Akiko Okano; Chung Liang Lim; Yushi Futamura; Takeshi Shimizu; Shunji Takahashi; Darah Ibrahim; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2016-09-07       Impact factor: 2.649

4.  RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441.

Authors:  Jun-Pil Jang; Shunji Takahashi; Yushi Futamura; Toshihiko Nogawa; Jae-Hyuk Jang; Jong Seog Ahn; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2016-06-08       Impact factor: 2.649

5.  Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058.

Authors:  Toshihiko Nogawa; Naoki Kato; Takeshi Shimizu; Akiko Okano; Yushi Futamura; Shunji Takahashi; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2017-09-13       Impact factor: 2.649

6.  Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.

Authors:  Katherine R Duncan; Max Crüsemann; Anna Lechner; Anindita Sarkar; Jie Li; Nadine Ziemert; Mingxun Wang; Nuno Bandeira; Bradley S Moore; Pieter C Dorrestein; Paul R Jensen
Journal:  Chem Biol       Date:  2015-04-09

7.  Cytotoxic and Optically Active Pyrisulfoxins From the Endophytic Streptomyces albolongus EA12432.

Authors:  Yuqi Du; Chen Wang; Guodong Cui; Yiwen Chu; Qian Jia; Yi Wang; Weiming Zhu
Journal:  Front Chem       Date:  2020-05-06       Impact factor: 5.221

8.  New 3-Hydroxyquinaldic Acid Derivatives from Cultures of the Marine Derived Actinomycete Streptomyces cyaneofuscatus M-157.

Authors:  Francisco Javier Ortiz-López; Elsa Alcalde; Aida Sarmiento-Vizcaíno; Caridad Díaz; Bastien Cautain; Luis A García; Gloria Blanco; Fernando Reyes
Journal:  Mar Drugs       Date:  2018-10-08       Impact factor: 5.118
  8 in total

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