Literature DB >> 28322495

Polyketide Synthase Modules Redefined.

Adrian T Keatinge-Clay1.   

Abstract

Modular redefinition: A long-standing paradigm in modular polyketide synthase enzymology, namely the definition of a module, has been challenged by Abe and co-workers in their recent study. With this new understanding has emerged renewed hope for engineering these assembly lines to produce new materials and medicines.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  assembly lines; enzymology; evolution-guided engineering; modules; polyketides

Mesh：

Substances：

Year:  2017        PMID： 28322495      PMCID： PMC6454894          DOI： 10.1002/anie.201701281

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  20 in total

Review 1.  The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.

Authors:  Adrian T Keatinge-Clay
Journal:  Chem Rev       Date:  2017-04-10       Impact factor: 60.622

2.  The modules of trans-acyltransferase assembly lines redefined with a central acyl carrier protein.

Authors:  Drew A Vander Wood; Adrian T Keatinge-Clay
Journal:  Proteins       Date:  2018-03-25

3.  Insights into β-ketoacyl-chain recognition for β-ketoacyl-ACP utilizing AHL synthases.

Authors:  Mila Nhu Lam; Dastagiri Dudekula; Bri Durham; Noah Collingwood; Eric C Brown; Rajesh Nagarajan
Journal:  Chem Commun (Camb)       Date:  2018-08-07       Impact factor: 6.222

4.  Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.

Authors:  Miles S Dickinson; Takeshi Miyazawa; Ryan S McCool; Adrian T Keatinge-Clay
Journal:  Structure       Date:  2022-06-22       Impact factor: 5.871

5.  Preparative production of an enantiomeric pair by engineered polyketide synthases.

Authors:  Takeshi Miyazawa; Brendan J Fitzgerald; Adrian T Keatinge-Clay
Journal:  Chem Commun (Camb)       Date:  2021-08-11       Impact factor: 6.065

6.  Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains.

Authors:  Maja Klaus; Alicia D D'Souza; Aleksandra Nivina; Chaitan Khosla; Martin Grininger
Journal:  ACS Chem Biol       Date:  2019-02-11       Impact factor: 5.100

7.  Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.

Authors:  Drew T Wagner; Zhicheng Zhang; Roy A Meoded; Alexis J Cepeda; Jörn Piel; Adrian T Keatinge-Clay
Journal:  ACS Chem Biol       Date:  2018-03-01       Impact factor: 5.100

8.  General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases.

Authors:  Zhicheng Zhang; Alexis J Cepeda; Mireya L Robles; Melissa Hirsch; Kaan Kumru; Jina A Zhou; Adrian T Keatinge-Clay
Journal:  Chem Commun (Camb)       Date:  2019-12-17       Impact factor: 6.222

9.  Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase.

Authors:  Kei Kudo; Takehiro Nishimura; Ikuko Kozone; Junko Hashimoto; Noritaka Kagaya; Hikaru Suenaga; Haruo Ikeda; Kazuo Shin-Ya
Journal:  Sci Rep       Date:  2021-05-11       Impact factor: 4.379

Review 10.  Recent trends in biocatalysis.

Authors:  Dong Yi; Thomas Bayer; Christoffel P S Badenhorst; Shuke Wu; Mark Doerr; Matthias Höhne; Uwe T Bornscheuer
Journal:  Chem Soc Rev       Date:  2021-06-18       Impact factor: 60.615
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