| Literature DB >> 31799975 |
Zhicheng Zhang1, Alexis J Cepeda, Mireya L Robles, Melissa Hirsch, Kaan Kumru, Jina A Zhou, Adrian T Keatinge-Clay.
Abstract
Modular polyketide synthases (PKSs) are enzymatic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.Entities:
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Year: 2019 PMID： 31799975 PMCID： PMC7172026 DOI： 10.1039/c9cc07966a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222