Literature DB >> 30027952

Insights into β-ketoacyl-chain recognition for β-ketoacyl-ACP utilizing AHL synthases.

Mila Nhu Lam1, Dastagiri Dudekula, Bri Durham, Noah Collingwood, Eric C Brown, Rajesh Nagarajan.   

Abstract

Beta-ketoacyl-ACP utilizing enzymes in fatty acid, polyketide and acyl-homoserine lactone biosynthetic pathways are important targets for developing antimicrobial, anticancer and antiparasitic compounds. Published reports on successful isolation of beta-ketoacyl-ACPs in a laboratory remain scarce to date and thus most beta-ketoacyl-ACP utilizing enzymes are routinely characterized using small molecule substrates in lieu of the bonafide 3-oxoacyl-ACPs. We report the systematic investigation into the electronic, geometric and spatial aspects of beta-ketoacyl-chain recognition to develop 3-oxoacyl-ACP substrate mimics for two beta-ketoacyl-ACP utilizing quorum signal synthases.

Entities:  

Mesh：

Substances：

Year:  2018        PMID： 30027952      PMCID： PMC6124316          DOI： 10.1039/c8cc04532a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  26 in total

Review 1.  Quorum sensing: cell-to-cell communication in bacteria.

Authors:  Christopher M Waters; Bonnie L Bassler
Journal:  Annu Rev Cell Dev Biol       Date:  2005       Impact factor: 13.827

2.  Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.

Authors:  B A Pfeifer; S J Admiraal; H Gramajo; D E Cane; C Khosla
Journal:  Science       Date:  2001-03-02       Impact factor: 47.728

3.  Specificity of acyl-homoserine lactone synthases examined by mass spectrometry.

Authors:  Ty A Gould; Jake Herman; Jessica Krank; Robert C Murphy; Mair E A Churchill
Journal:  J Bacteriol       Date:  2006-01       Impact factor: 3.490

4.  Structural basis and specificity of acyl-homoserine lactone signal production in bacterial quorum sensing.

Authors:  William T Watson; Timothy D Minogue; Dale L Val; Susanne Beck von Bodman; Mair E A Churchill
Journal:  Mol Cell       Date:  2002-03       Impact factor: 17.970

Review 5.  The enzymes of bacterial census and censorship.

Authors:  Walter Fast; Peter A Tipton
Journal:  Trends Biochem Sci       Date:  2011-11-16       Impact factor: 13.807

6.  α-Methylation follows condensation in the gephyronic acid modular polyketide synthase.

Authors:  Drew T Wagner; D Cole Stevens; M Rachel Mehaffey; Hannah R Manion; Richard E Taylor; Jennifer S Brodbelt; Adrian T Keatinge-Clay
Journal:  Chem Commun (Camb)       Date:  2016-07-07       Impact factor: 6.222

7.  A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases.

Authors:  Quin H Christensen; Tyler L Grove; Squire J Booker; E Peter Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-07       Impact factor: 11.205

8.  Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways.

Authors:  John E Cronan; Jacob Thomas
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

9.  S···O and S···N Sulfur Bonding Interactions in Protein-Ligand Complexes: Empirical Considerations and Scoring Function.

Authors:  Mathew R Koebel; Aaron Cooper; Grant Schmadeke; Soyoung Jeon; Mahesh Narayan; Suman Sirimulla
Journal:  J Chem Inf Model       Date:  2016-12-12       Impact factor: 4.956

10.  Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases.

Authors:  Alistair K Brown; Rebecca C Taylor; Apoorva Bhatt; Klaus Fütterer; Gurdyal S Besra
Journal:  PLoS One       Date:  2009-07-17       Impact factor: 3.240
View more
  1 in total

1.  N-Acyl Homoserine Lactone Analog Modulators of the Pseudomonas aeruginosa Rhll Quorum Sensing Signal Synthase.

Authors:  Daniel Shin; Christoph Gorgulla; Michelle E Boursier; Neilson Rexrode; Eric C Brown; Haribabu Arthanari; Helen E Blackwell; Rajesh Nagarajan
Journal:  ACS Chem Biol       Date:  2019-10-09       Impact factor: 5.100
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.