S Hara1, Y Tanaka2, Y Ueda1, S Hayashi1, M Inaji1,3, K Ishiwata3, K Ishii3, T Maehara1, T Nariai1,3. 1. From the Department of Neurosurgery (S.H., Y.T., Y.U., S.H., M.I., T.M., T.N.), Tokyo Medical and Dental University, Tokyo, Japan. 2. From the Department of Neurosurgery (S.H., Y.T., Y.U., S.H., M.I., T.M., T.N.), Tokyo Medical and Dental University, Tokyo, Japan tanaka.nsrg@tmd.ac.jp. 3. Research Team for Neuroimaging (M.I., K. Ishiwata, K. Ishii, T.N.), Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Abstract
BACKGROUND AND PURPOSE: Arterial spin-labeling MR imaging with multiple postlabeling delays has a potential to evaluate various hemodynamic parameters. To clarify whether arterial spin-labeling MR imaging can identify CBF and perfusion delay in patients with Moyamoya disease, we compared arterial spin-labeling, DSC, and 15O-gas PET in terms of their ability to identify these parameters. MATERIALS AND METHODS: Eighteen patients with Moyamoya disease (5 men, 13 women; ages, 21-55 years) were retrospectively analyzed. CBF values of pulsed continuous arterial spin-labeling using 2 postlabeling delays (short arterial spin-labeling, 1525 ms; delayed arterial spin-labeling, 2525 ms) were compared with CBF values measured by 15O-gas PET. All plots were divided into 2 groups by the cutoff of time-based parameters (the time of the maximum observed concentration, TTP, MTT, delay of MTT to cerebellum, and disease severity [symptomatic or not]). The ratio of 2 arterial spin-labeling CBFs (delayed arterial spin-labeling CBF to short arterial spin-labeling CBF) was compared with time-based parameters: time of the maximum observed concentration, TTP, and MTT. RESULTS: The short arterial spin-labeling-CBF values were significantly correlated with the PET-CBF values (r = 0.63; P = .01). However, the short arterial spin-labeling-CBF value dropped in the regions with severe perfusion delay. The delayed arterial spin-labeling CBF overestimated PET-CBF regardless of the degree of perfusion delay. Delayed arterial spin-labeling CBF/short arterial spin-labeling CBF was well correlated with the time of the maximum observed concentration, TTP, and MTT (ρ = 0.71, 0.64, and 0.47, respectively). CONCLUSIONS: Arterial spin-labeling using 2 postlabeling delays may detect PET-measured true CBF and perfusion delay in patients with Moyamoya disease. Provided its theoretic basis and limitations are considered, noninvasive arterial spin-labeling could be a useful alternative for evaluating the hemodynamics of Moyamoya disease.
BACKGROUND AND PURPOSE: Arterial spin-labeling MR imaging with multiple postlabeling delays has a potential to evaluate various hemodynamic parameters. To clarify whether arterial spin-labeling MR imaging can identify CBF and perfusion delay in patients with Moyamoya disease, we compared arterial spin-labeling, DSC, and 15O-gas PET in terms of their ability to identify these parameters. MATERIALS AND METHODS: Eighteen patients with Moyamoya disease (5 men, 13 women; ages, 21-55 years) were retrospectively analyzed. CBF values of pulsed continuous arterial spin-labeling using 2 postlabeling delays (short arterial spin-labeling, 1525 ms; delayed arterial spin-labeling, 2525 ms) were compared with CBF values measured by 15O-gas PET. All plots were divided into 2 groups by the cutoff of time-based parameters (the time of the maximum observed concentration, TTP, MTT, delay of MTT to cerebellum, and disease severity [symptomatic or not]). The ratio of 2 arterial spin-labeling CBFs (delayed arterial spin-labeling CBF to short arterial spin-labeling CBF) was compared with time-based parameters: time of the maximum observed concentration, TTP, and MTT. RESULTS: The short arterial spin-labeling-CBF values were significantly correlated with the PET-CBF values (r = 0.63; P = .01). However, the short arterial spin-labeling-CBF value dropped in the regions with severe perfusion delay. The delayed arterial spin-labeling CBF overestimated PET-CBF regardless of the degree of perfusion delay. Delayed arterial spin-labeling CBF/short arterial spin-labeling CBF was well correlated with the time of the maximum observed concentration, TTP, and MTT (ρ = 0.71, 0.64, and 0.47, respectively). CONCLUSIONS: Arterial spin-labeling using 2 postlabeling delays may detect PET-measured true CBF and perfusion delay in patients with Moyamoya disease. Provided its theoretic basis and limitations are considered, noninvasive arterial spin-labeling could be a useful alternative for evaluating the hemodynamics of Moyamoya disease.
Authors: F Q Ye; K F Berman; T Ellmore; G Esposito; J D van Horn; Y Yang; J Duyn; A M Smith; J A Frank; D R Weinberger; A C McLaughlin Journal: Magn Reson Med Date: 2000-09 Impact factor: 4.668
Authors: Jinhao Lyu; Ning Ma; David S Liebeskind; Danny J J Wang; Lin Ma; Yang Xu; Ting Wang; Zhongrong Miao; Xin Lou Journal: Stroke Date: 2016-01-05 Impact factor: 7.914
Authors: David C Alsop; John A Detre; Xavier Golay; Matthias Günther; Jeroen Hendrikse; Luis Hernandez-Garcia; Hanzhang Lu; Bradley J MacIntosh; Laura M Parkes; Marion Smits; Matthias J P van Osch; Danny J J Wang; Eric C Wong; Greg Zaharchuk Journal: Magn Reson Med Date: 2014-04-08 Impact factor: 4.668
Authors: S Hara; Y Tanaka; S Hayashi; M Inaji; T Maehara; M Hori; S Aoki; K Ishii; T Nariai Journal: AJNR Am J Neuroradiol Date: 2019-10-10 Impact factor: 3.825
Authors: S Hara; M Hori; A Hagiwara; Y Tsurushima; Y Tanaka; T Maehara; S Aoki; T Nariai Journal: AJNR Am J Neuroradiol Date: 2020-08-27 Impact factor: 3.825
Authors: Audrey P Fan; Jia Guo; Mohammad M Khalighi; Praveen K Gulaka; Bin Shen; Jun Hyung Park; Harsh Gandhi; Dawn Holley; Omar Rutledge; Prachi Singh; Tom Haywood; Gary K Steinberg; Frederick T Chin; Greg Zaharchuk Journal: Stroke Date: 2017-08-01 Impact factor: 7.914
Authors: Caiyu Zhuang; Julien Poublanc; Larissa Mcketton; Lakshmikumar Venkatraghavan; Olivia Sobczyk; James Duffin; Adrian P Crawley; Joseph A Fisher; Renhua Wu; David J Mikulis Journal: Quant Imaging Med Surg Date: 2021-02
Authors: K Setta; T Matsuda; M Sasaki; T Chiba; S Fujiwara; M Kobayashi; K Yoshida; Y Kubo; M Suzuki; K Yoshioka; K Ogasawara Journal: AJNR Am J Neuroradiol Date: 2021-05-20 Impact factor: 4.966
Authors: Ji Young Ha; Young Hun Choi; Seunghyun Lee; Yeon Jin Cho; Jung Eun Cheon; In One Kim; Woo Sun Kim Journal: Korean J Radiol Date: 2019-06 Impact factor: 3.500