| Literature DB >> 28148583 |
Abstract
The vasculitides are a heterogeneous group of conditions typified by their ability to cause vessel inflammation with or without necrosis. They present with a wide variety of signs and symptoms and, if left untreated, carry a significant burden of mortality and morbidity. The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are three separate conditions - granulomatosis with polyangiitis (GPA; formerly known as Wegener's granulomatosis), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA; previously known as Churg-Strauss syndrome). This review examines recent developments in the pathogenesis and treatment of AAV, focusing on developments in treatment following the introduction of rituximab, in particular. © Royal College of Physicians 2017. All rights reserved.Entities:
Keywords: ANCA; diagnosis; rituximab; treatment; vasculitis
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Year: 2017 PMID: 28148583 PMCID: PMC6297586 DOI: 10.7861/clinmedicine.17-1-60
Source DB: PubMed Journal: Clin Med (Lond) ISSN: 1470-2118 Impact factor: 2.659