Rabah Al-Mehisen1, Khalid Alnemri1, Maha Al-Mohaissen2,3. 1. Department of Cardiology, Security Forces Hospital, Riyadh, Kingdom of Saudi Arabia. 2. Department of Clinical Sciences (Cardiology), College of Medicine, Princess Nourah Bint Abdulrahman University, PO Box 48247, Riyadh, 11511, Kingdom of Saudi Arabia. mahaabdulrahman@hotmail.com. 3. Princess Nourah Bint Abdulrahman University Cardiovascular Disease in Women Research Chair, Riyadh, Kingdom of Saudi Arabia. mahaabdulrahman@hotmail.com.
Abstract
BACKGROUND: Recent evidence suggests that cardiac involvement in patients with granulomatosis with polyangiitis (GPA) occurs more frequently than previously reported. Multimodality cardiac imaging is gaining attention in the diagnosis, prognostication, and follow-up of such patients; however, the data remain scarce. RESULTS: 2D-TTE was useful for initial screening; while both cardiac magnetic resonance imaging and 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) metabolic imaging with rubidium-82 PET perfusion imaging were useful for characterization of myocardial disease. 18FDG-PET/CT was very useful for the follow-up of cardiac disease activity following treatment. CONCLUSION: 18FDG-PET/CT is sensitive for the detection of cardiac involvement by GPA and is useful for the tissue characterization and follow-up of disease activity following treatment.
BACKGROUND: Recent evidence suggests that cardiac involvement in patients with granulomatosis with polyangiitis (GPA) occurs more frequently than previously reported. Multimodality cardiac imaging is gaining attention in the diagnosis, prognostication, and follow-up of such patients; however, the data remain scarce. RESULTS: 2D-TTE was useful for initial screening; while both cardiac magnetic resonance imaging and 18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) metabolic imaging with rubidium-82 PET perfusion imaging were useful for characterization of myocardial disease. 18FDG-PET/CT was very useful for the follow-up of cardiac disease activity following treatment. CONCLUSION: 18FDG-PET/CT is sensitive for the detection of cardiac involvement by GPA and is useful for the tissue characterization and follow-up of disease activity following treatment.
Entities:
Keywords:
2-dimensional-echocardiography; Granulomatosis with polyangiitis; Wegner’s granulomatosis; cardiac imaging; cardiac involvement; cardiac magnetic resonance; myocardial perfusion imaging; positron emission tomography
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