Koichi Okuda1, Kenichi Nakajima2, Shinro Matsuo3, Chisato Kondo4, Masayoshi Sarai5, Yoriko Horiguchi6, Takahiro Konishi7, Masahisa Onoguchi8, Takeshi Shimizu9, Seigo Kinuya3. 1. Department of Physics, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa, 920-0293, Japan. okuda@kanazawa-med.ac.jp. 2. Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan. nakajima@med.kanazawa-u.ac.jp. 3. Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan. 4. Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical University Hospital, Tokyo, Japan. 5. Department of Cardiology, Fujita Health University Hospital, Aichi, Japan. 6. Department of Cardiology, National Hospital Organization Sagamihara National Hospital, Kanagawa, Japan. 7. Department of Radiology, Kanazawa University Hospital, Kanazawa, Japan. 8. Department of Quantum Medical Technology, Kanazawa University, Kanazawa, Japan. 9. Department of Molecular Imaging, Siemens Healthcare K.K., Tokyo, Japan.
Abstract
BACKGROUND: Image acquisition by short-time single-photon emission-computed tomography (SPECT) has been made feasible by IQ·SPECT. The aim of this study was to generate normal databases (NDBs) of thallium-201 (201Tl) myocardial perfusion imaging for IQ·SPECT, and characterize myocardial perfusion distribution. METHODS AND RESULTS: We retrospectively enrolled 159 patients with a low likelihood of cardiac diseases from four hospitals in Japan. All patients underwent short-time 201Tl myocardial perfusion IQ·SPECT with or without attenuation and scatter correction (ACSC) in either supine or prone position. The mean myocardial counts were calculated using 17-segment polar maps. Three NDBs were derived from supine and prone images as well as supine images with ACSC. Differences between the supine and prone positions were observed in the uncorrected sex-segregated NDBs in the mid-inferolateral counts (p ≤ 0.016 for males and p ≤ 0.002 for females). Differences between IQ·SPECT and conventional SPECT were also observed in the mid-anterior, inferolateral, and apical lateral counts (p ≤ 0.009 for males and p ≤ 0.003 for females). Apical low counts attributed to myocardial thinning were observed in the apical anterior and apex segments in the supine IQ·SPECT NDB with ACSC. CONCLUSIONS: There were significant differences between uncorrected supine and prone NDBs, between uncorrected supine NDB and supine NDB with ACSC, and between uncorrected supine NDB and conventional SPECT NDB. Understanding the pattern of normal distribution in IQ-SPECT short-time acquisitions with and without ACSC will be helpful for interpretation of imaging findings in patients with coronary artery disease (CAD) or low likelihood of CAD and the NDBs will aid in quantitative analysis.
BACKGROUND: Image acquisition by short-time single-photon emission-computed tomography (SPECT) has been made feasible by IQ·SPECT. The aim of this study was to generate normal databases (NDBs) of thallium-201 (201Tl) myocardial perfusion imaging for IQ·SPECT, and characterize myocardial perfusion distribution. METHODS AND RESULTS: We retrospectively enrolled 159 patients with a low likelihood of cardiac diseases from four hospitals in Japan. All patients underwent short-time 201Tl myocardial perfusion IQ·SPECT with or without attenuation and scatter correction (ACSC) in either supine or prone position. The mean myocardial counts were calculated using 17-segment polar maps. Three NDBs were derived from supine and prone images as well as supine images with ACSC. Differences between the supine and prone positions were observed in the uncorrected sex-segregated NDBs in the mid-inferolateral counts (p ≤ 0.016 for males and p ≤ 0.002 for females). Differences between IQ·SPECT and conventional SPECT were also observed in the mid-anterior, inferolateral, and apical lateral counts (p ≤ 0.009 for males and p ≤ 0.003 for females). Apical low counts attributed to myocardial thinning were observed in the apical anterior and apex segments in the supine IQ·SPECT NDB with ACSC. CONCLUSIONS: There were significant differences between uncorrected supine and prone NDBs, between uncorrected supine NDB and supine NDB with ACSC, and between uncorrected supine NDB and conventional SPECT NDB. Understanding the pattern of normal distribution in IQ-SPECT short-time acquisitions with and without ACSC will be helpful for interpretation of imaging findings in patients with coronary artery disease (CAD) or low likelihood of CAD and the NDBs will aid in quantitative analysis.
Authors: Martin Havel; Michal Kolacek; Milan Kaminek; Vladimir Dedek; Otakar Kraft; Pavel Sirucek Journal: Hell J Nucl Med Date: 2014 Sep-Dec Impact factor: 1.102
Authors: Federico Caobelli; Stefano Ren Kaiser; James T Thackeray; Frank M Bengel; Matteo Chieregato; Alberto Soffientini; Claudio Pizzocaro; Giordano Savelli; Marco Galelli; Ugo Paolo Guerra Journal: J Nucl Med Date: 2014-11-20 Impact factor: 10.057