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Literature DB >> 27960349

Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase.

Li Li¹, Peiyuan Yu, Man-Cheng Tang, Yi Zou, Shu-Shan Gao, Yiu-Sun Hung, Muxun Zhao, Kenji Watanabe², K N Houk, Yi Tang.

Abstract

The trans-decalin structure formed by intramolecular Diels-Alder cycloaddition is widely present among bioactive natural products isolated from fungi. We elucidated the concise three-enzyme biosynthetic pathway of the cytotoxic myceliothermophin and biochemically characterized the Diels-Alderase that catalyzes the formation of trans-decalin from an acyclic substrate. Computational studies of the reaction mechanism rationalize both the substrate and stereoselectivity of the enzyme.

Entities: CellLine Chemical Disease Species

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Year: 2016 PMID： 27960349 PMCID： PMC5323083 DOI： 10.1021/jacs.6b10452

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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