Literature DB >> 27814486

Mediator: A Drawbridge across the Enhancer-Promoter Divide.

Sohail Malik1, Robert G Roeder2.   

Abstract

Two papers in this issue of Molecular Cell provide insights into how the multisubunit Mediator coactivator complex dynamically links enhancer-bound activators to the RNA polymerase II machinery at the core promoter.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27814486      PMCID： PMC6114138          DOI： 10.1016/j.molcel.2016.10.024

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  8 in total

1.  Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator.

Authors:  Sohail Malik; Hwa Jin Baek; Weizhen Wu; Robert G Roeder
Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

2.  Architecture of the RNA polymerase II-Mediator core initiation complex.

Authors:  C Plaschka; L Larivière; L Wenzeck; M Seizl; M Hemann; D Tegunov; E V Petrotchenko; C H Borchers; W Baumeister; F Herzog; E Villa; P Cramer
Journal:  Nature       Date:  2015-02-04       Impact factor: 49.962

3.  Super-enhancers in the control of cell identity and disease.

Authors:  Denes Hnisz; Brian J Abraham; Tong Ihn Lee; Ashley Lau; Violaine Saint-André; Alla A Sigova; Heather A Hoke; Richard A Young
Journal:  Cell       Date:  2013-10-10       Impact factor: 41.582

4.  PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator.

Authors:  Rushad Pavri; Brian Lewis; Tae-Kyung Kim; F Jeffrey Dilworth; Hediye Erdjument-Bromage; Paul Tempst; Gilbert de Murcia; Ronald Evans; Pierre Chambon; Danny Reinberg
Journal:  Mol Cell       Date:  2005-04-01       Impact factor: 17.970

5.  Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex.

Authors:  Philip J Robinson; Michael J Trnka; David A Bushnell; Ralph E Davis; Pierre-Jean Mattei; Alma L Burlingame; Roger D Kornberg
Journal:  Cell       Date:  2016-09-08       Impact factor: 41.582

6.  Enhancer Control of Transcriptional Bursting.

Authors:  Takashi Fukaya; Bomyi Lim; Michael Levine
Journal:  Cell       Date:  2016-06-09       Impact factor: 41.582

Review 7.  The Mediator complex: a central integrator of transcription.

Authors:  Benjamin L Allen; Dylan J Taatjes
Journal:  Nat Rev Mol Cell Biol       Date:  2015-02-18       Impact factor: 94.444

8.  Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.

Authors:  Murat A Cevher; Yi Shi; Dan Li; Brian T Chait; Sohail Malik; Robert G Roeder
Journal:  Nat Struct Mol Biol       Date:  2014-11-10       Impact factor: 15.369
  8 in total
  12 in total

1.  Mediator subunit MED1 is required for E2A-PBX1-mediated oncogenic transcription and leukemic cell growth.

Authors:  Yu-Ling Lee; Keiichi Ito; Wen-Chieh Pi; I-Hsuan Lin; Chi-Shuen Chu; Sohail Malik; I-Hsin Cheng; Wei-Yi Chen; Robert G Roeder
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-09       Impact factor: 11.205

2.  Regulation of hepatocyte cell cycle re-entry by RNA polymerase II-associated Gdown1.

Authors:  Miki Jishage; Robert G Roeder
Journal:  Cell Cycle       Date:  2020-11-25       Impact factor: 4.534

3.  SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription.

Authors:  Anil K Panigrahi; Charles E Foulds; Rainer B Lanz; Ross A Hamilton; Ping Yi; David M Lonard; Ming-Jer Tsai; Sophia Y Tsai; Bert W O'Malley
Journal:  Mol Cell       Date:  2018-05-17       Impact factor: 17.970

4.  Candida glabrata Med3 Plays a Role in Altering Cell Size and Budding Index To Coordinate Cell Growth.

Authors:  Hui Liu; Lulin Kong; Yanli Qi; Xiulai Chen; Liming Liu
Journal:  Appl Environ Microbiol       Date:  2018-07-17       Impact factor: 4.792

Review 5.  50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms.

Authors:  Robert G Roeder
Journal:  Nat Struct Mol Biol       Date:  2019-08-22       Impact factor: 15.369

6.  Multivalent Role of Human TFIID in Recruiting Elongation Components at the Promoter-Proximal Region for Transcriptional Control.

Authors:  Dipika Yadav; Koushik Ghosh; Subham Basu; Robert G Roeder; Debabrata Biswas
Journal:  Cell Rep       Date:  2019-01-29       Impact factor: 9.423

7.  Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage.

Authors:  Chi-Shuen Chu; Johannes C Hellmuth; Rajat Singh; Hsia-Yuan Ying; Lucy Skrabanek; Matthew R Teater; Ashley S Doane; Olivier Elemento; Ari M Melnick; Robert G Roeder
Journal:  Mol Cell       Date:  2020-11-23       Impact factor: 19.328

Review 8.  Enhancers and chromatin structures: regulatory hubs in gene expression and diseases.

Authors:  Zhenhua Hu; Wee-Wei Tee
Journal:  Biosci Rep       Date:  2017-04-28       Impact factor: 3.840

9.  Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

Authors:  Miki Jishage; Xiaodi Yu; Yi Shi; Sai J Ganesan; Wei-Yi Chen; Andrej Sali; Brian T Chait; Francisco J Asturias; Robert G Roeder
Journal:  Nat Struct Mol Biol       Date:  2018-09-06       Impact factor: 15.369

10.  Gene Transcription as a Limiting Factor in Protein Production and Cell Growth.

Authors:  Eyal Metzl-Raz; Moshe Kafri; Gilad Yaakov; Naama Barkai
Journal:  G3 (Bethesda)       Date:  2020-09-02       Impact factor: 3.154
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