Literature DB >> 27740946

A multiplexed TOF and DOI capable PET detector using a binary position sensitive network.

M F Bieniosek1, J W Cates, C S Levin.   

Abstract

Time of flight (TOF) and depth of interaction (DOI) capabilities can significantly enhance the quality and uniformity of positron emission tomography (PET) images. Many proposed TOF/DOI PET detectors require complex readout systems using additional photosensors, active cooling, or waveform sampling. This work describes a high performance, low complexity, room temperature TOF/DOI PET module. The module uses multiplexed timing channels to significantly reduce the electronic readout complexity of the PET detector while maintaining excellent timing, energy, and position resolution. DOI was determined using a two layer light sharing scintillation crystal array with a novel binary position sensitive network. A 20 mm effective thickness LYSO crystal array with four 3 mm  ×  3 mm silicon photomultipliers (SiPM) read out by a single timing channel, one energy channel and two position channels achieved a full width half maximum (FWHM) coincidence time resolution of 180  ±  2 ps with 10 mm of DOI resolution and 11% energy resolution. With sixteen 3 mm  ×  3 mm SiPMs read out by a single timing channel, one energy channel and four position channels a coincidence time resolution 204  ±  1 ps was achieved with 10 mm of DOI resolution and 15% energy resolution. The methods presented here could significantly simplify the construction of high performance TOF/DOI PET detectors.

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Year:  2016        PMID: 27740946      PMCID: PMC5116435          DOI: 10.1088/0031-9155/61/21/7639

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  15 in total

1.  Investigating the temporal resolution limits of scintillation detection from pixellated elements: comparison between experiment and simulation.

Authors:  V Ch Spanoudaki; C S Levin
Journal:  Phys Med Biol       Date:  2011-01-14       Impact factor: 3.609

2.  Side readout of long scintillation crystal elements with digital SiPM for TOF-DOI PET.

Authors:  Jung Yeol Yeom; Ruud Vinke; Craig S Levin
Journal:  Med Phys       Date:  2014-12       Impact factor: 4.071

3.  Continuous depth-of-interaction measurement in a single-layer pixelated crystal array using a single-ended readout.

Authors:  Mikiko Ito; Min Sun Lee; Jae Sung Lee
Journal:  Phys Med Biol       Date:  2013-02-06       Impact factor: 3.609

4.  Analog filtering methods improve leading edge timing performance of multiplexed SiPMs.

Authors:  M F Bieniosek; J W Cates; A M Grant; C S Levin
Journal:  Phys Med Biol       Date:  2016-08-03       Impact factor: 3.609

5.  Time-of-flight positron emission tomography: status relative to conventional PET.

Authors:  T F Budinger
Journal:  J Nucl Med       Date:  1983-01       Impact factor: 10.057

6.  Feasibility of time-of-flight reconstruction in positron emission tomography.

Authors:  N A Mullani; J Markham; M M Ter-Pogossian
Journal:  J Nucl Med       Date:  1980-11       Impact factor: 10.057

7.  Characterization of stacked-crystal PET detector designs for measurement of both TOF and DOI.

Authors:  Jeffrey P Schmall; Suleman Surti; Joel S Karp
Journal:  Phys Med Biol       Date:  2015-04-10       Impact factor: 3.609

8.  Investigation of analog charge multiplexing schemes for SiPM based PET block detectors.

Authors:  Evan Downie; Xin Yang; Hao Peng
Journal:  Phys Med Biol       Date:  2013-05-16       Impact factor: 3.609

9.  Predicting the timing properties of phosphor-coated scintillators using Monte Carlo light transport simulation.

Authors:  Emilie Roncali; Jeffrey P Schmall; Varsha Viswanath; Eric Berg; Simon R Cherry
Journal:  Phys Med Biol       Date:  2014-04-02       Impact factor: 3.609

10.  Achieving fast timing performance with multiplexed SiPMs.

Authors:  M F Bieniosek; J W Cates; C S Levin
Journal:  Phys Med Biol       Date:  2016-03-17       Impact factor: 3.609

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  1 in total

1.  A preclinical PET detector constructed with a monolithic scintillator ring.

Authors:  Jianfeng Xu; Siwei Xie; Xi Zhang; Weijie Tao; Jingwu Yang; Zhixiang Zhao; Fenghua Weng; Qiu Huang; Fei Yi; Qiyu Peng
Journal:  Phys Med Biol       Date:  2019-08-07       Impact factor: 3.609

  1 in total

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