Literature DB >> 2773938

High-resolution analysis of a hypervariable region in the human apolipoprotein B gene.

E H Ludwig1, W Friedl, B J McCarthy.   

Abstract

A hypervariable region occurs immediately 3' of the human apolipoprotein B gene. Several allelic variants of this tandemly repeated sequence can be resolved by genomic blotting. Higher resolution among size variants may be obtained by polymerase-chain-reaction amplification of this region followed by electrophoresis in a denaturing acrylamide gel. Fourteen different alleles containing 25-52 repeats of the basic 15-bp unit were distinguished in a population study of 318 unrelated individuals. This approach should be applicable to pedigree and linkage analysis with the apolipoprotein B gene or other tandemly repeated sequence elements.

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Year:  1989        PMID： 2773938      PMCID： PMC1683401     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  23 in total

1.  Using mini-prep plasmid DNA for sequencing double stranded templates with Sequenase.

Authors:  R Kraft; J Tardiff; K S Krauter; L A Leinwand
Journal:  Biotechniques       Date:  1988-06       Impact factor: 1.993

2.  Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins.

Authors:  K H Weisgraber; T L Innerarity; Y M Newhouse; S G Young; K S Arnold; R M Krauss; G L Vega; S M Grundy; R W Mahley
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

3.  Amplification of human minisatellites by the polymerase chain reaction: towards DNA fingerprinting of single cells.

Authors:  A J Jeffreys; V Wilson; R Neumann; J Keyte
Journal:  Nucleic Acids Res       Date:  1988-12-09       Impact factor: 16.971

4.  Hypervariable 'minisatellite' regions in human DNA.

Authors:  A J Jeffreys; V Wilson; S L Thein
Journal:  Nature       Date:  1985 Mar 7-13       Impact factor: 49.962

5.  A highly polymorphic region 3' to the human type II collagen gene.

Authors:  N G Stoker; K S Cheah; J R Griffin; F M Pope; E Solomon
Journal:  Nucleic Acids Res       Date:  1985-07-11       Impact factor: 16.971

6.  The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences.

Authors:  G I Bell; M J Selby; W J Rutter
Journal:  Nature       Date:  1982-01-07       Impact factor: 49.962

7.  Apolipoprotein B-gene DNA polymorphisms associated with myocardial infarction.

Authors:  R A Hegele; L S Huang; P N Herbert; C B Blum; J E Buring; C H Hennekens; J L Breslow
Journal:  N Engl J Med       Date:  1986-12-11       Impact factor: 91.245

8.  Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100.

Authors:  L F Soria; E H Ludwig; H R Clarke; G L Vega; S M Grundy; B J McCarthy
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

9.  Structure of the human apolipoprotein B gene.

Authors:  B D Blackhart; E M Ludwig; V R Pierotti; L Caiati; M A Onasch; S C Wallis; L Powell; R Pease; T J Knott; M L Chu
Journal:  J Biol Chem       Date:  1986-11-25       Impact factor: 5.157

10.  Molecular characterisation of a hypervariable region downstream of the human alpha-globin gene cluster.

Authors:  A P Jarman; R D Nicholls; D J Weatherall; J B Clegg; D R Higgs
Journal:  EMBO J       Date:  1986-08       Impact factor: 11.598
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  24 in total

1.  Population genetics and forensic efficiency data of 4 AMPFLP's.

Authors:  S Rand; C Puers; K Skowasch; P Wiegand; B Budowle; B Brinkmann
Journal:  Int J Legal Med       Date:  1992       Impact factor: 2.686

2.  PCR amplification of alleles at the DIS80 locus: comparison of a Finnish and a North American Caucasian population sample, and forensic casework evaluation.

Authors:  A Sajantila; B Budowle; M Ström; V Johnsson; M Lukka; L Peltonen; C Ehnholm
Journal:  Am J Hum Genet       Date:  1992-04       Impact factor: 11.025

3.  Variable number of tandem repeat (VNTR) polymorphism at locus D17S5 (YNZ22) in four ethnically defined human populations.

Authors:  R Deka; S De Croo; L M Yu; R E Ferrell
Journal:  Hum Genet       Date:  1992 Sep-Oct       Impact factor: 4.132

4.  Characteristics of polymorphism at a VNTR locus 3' to the apolipoprotein B gene in five human populations.

Authors:  R Deka; R Chakraborty; S DeCroo; F Rothhammer; S A Barton; R E Ferrell
Journal:  Am J Hum Genet       Date:  1992-12       Impact factor: 11.025

5.  Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE.

Authors:  B Budowle; R Chakraborty; A M Giusti; A J Eisenberg; R C Allen
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

6.  Allele frequency estimation from data on relatives.

Authors:  M Boehnke
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

7.  Alkaline transfer of small restriction fragments from polyacrylamide gels.

Authors:  J J Martinson; J B Clegg
Journal:  Nucleic Acids Res       Date:  1990-03-11       Impact factor: 16.971

8.  The human minisatellite consensus at breakpoints of oncogene translocations.

Authors:  A M Krowczynska; R A Rudders; T G Krontiris
Journal:  Nucleic Acids Res       Date:  1990-03-11       Impact factor: 16.971

9.  Suitability of PCR methods for forensic investigation. Analysis of the 3'apoB VNTR system in an Italian population sample.

Authors:  R Giorgetti; A Tagliabracci; A Agostini; M Cingolani; S D Ferrara
Journal:  Int J Legal Med       Date:  1991       Impact factor: 2.686

10.  Associations between mutations and a VNTR in the human phenylalanine hydroxylase gene.

Authors:  A A Goltsov; R C Eisensmith; D S Konecki; U Lichter-Konecki; S L Woo
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025
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