Literature DB >> 27652374

Practical considerations for implementing genomic information resources. Experiences from eMERGE and CSER.

Luke V Rasmussen1, Casey L Overby, John Connolly, Christopher G Chute, Joshua C Denny, Robert Freimuth, Andrea L Hartzler, Ingrid A Holm, Shannon Manzi, Jyotishman Pathak, Peggy L Peissig, Maureen Smith, Marc S Williams, Brian H Shirts, Elena M Stoffel, Peter Tarczy-Hornoch, Carolyn R Rohrer Vitek, Wendy A Wolf, Justin Starren.   

Abstract

OBJECTIVES: To understand opinions and perceptions on the state of information resources specifically targeted to genomics, and approaches to delivery in clinical practice.
METHODS: We conducted a survey of genomic content use and its clinical delivery from representatives across eight institutions in the electronic Medical Records and Genomics (eMERGE) network and two institutions in the Clinical Sequencing Exploratory Research (CSER) consortium in 2014.
RESULTS: Eleven responses representing distinct projects across ten sites showed heterogeneity in how content is being delivered, with provider-facing content primarily delivered via the electronic health record (EHR) (n=10), and paper/pamphlets as the leading mode for patient-facing content (n=9). There was general agreement (91%) that new content is needed for patients and providers specific to genomics, and that while aspects of this content could be shared across institutions there remain site-specific needs (73% in agreement).
CONCLUSION: This work identifies a need for the improved access to and expansion of information resources to support genomic medicine, and opportunities for content developers and EHR vendors to partner with institutions to develop needed resources, and streamline their use - such as a central content site in multiple modalities while implementing approaches to allow for site-specific customization.

Entities:  

Keywords:  Electronic health records; clinical decision support; education; genetics; medicine

Mesh:

Year:  2016        PMID: 27652374      PMCID: PMC5052555          DOI: 10.4338/ACI-2016-04-RA-0060

Source DB:  PubMed          Journal:  Appl Clin Inform        ISSN: 1869-0327            Impact factor:   2.342


  37 in total

1.  Patient reported barriers to enrolling in a patient portal.

Authors:  Mita Sanghavi Goel; Tiffany L Brown; Adam Williams; Andrew J Cooper; Romana Hasnain-Wynia; David W Baker
Journal:  J Am Med Inform Assoc       Date:  2011-11-09       Impact factor: 4.497

2.  Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey.

Authors:  E J Stanek; C L Sanders; K A Johansen Taber; M Khalid; A Patel; R R Verbrugge; B C Agatep; R E Aubert; R S Epstein; F W Frueh
Journal:  Clin Pharmacol Ther       Date:  2012-01-25       Impact factor: 6.875

3.  Nurses transforming health care using genetics and genomics.

Authors:  Kathleen A Calzone; Ann Cashion; Suzanne Feetham; Jean Jenkins; Cynthia A Prows; Janet K Williams; Shu-Fen Wung
Journal:  Nurs Outlook       Date:  2010 Jan-Feb       Impact factor: 3.250

4.  Charting a course for genomic medicine from base pairs to bedside.

Authors:  Eric D Green; Mark S Guyer
Journal:  Nature       Date:  2011-02-10       Impact factor: 49.962

5.  Meeting the electronic health record "meaningful use" criterion for the HL7 infobutton standard using OpenInfobutton and the Librarian Infobutton Tailoring Environment (LITE).

Authors:  James J Cimino; Xia Jing; Guilherme Del Fiol
Journal:  AMIA Annu Symp Proc       Date:  2012-11-03

6.  Implementations of the HL7 Context-Aware Knowledge Retrieval ("Infobutton") Standard: challenges, strengths, limitations, and uptake.

Authors:  Guilherme Del Fiol; Vojtech Huser; Howard R Strasberg; Saverio M Maviglia; Clayton Curtis; James J Cimino
Journal:  J Biomed Inform       Date:  2012-01-02       Impact factor: 6.317

7.  Attitudes and practices among internists concerning genetic testing.

Authors:  Robert Klitzman; Wendy Chung; Karen Marder; Anita Shanmugham; Lisa J Chin; Meredith Stark; Cheng-Shiun Leu; Paul S Appelbaum
Journal:  J Genet Couns       Date:  2012-05-15       Impact factor: 2.537

8.  Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project.

Authors:  J M Pulley; J C Denny; J F Peterson; G R Bernard; C L Vnencak-Jones; A H Ramirez; J T Delaney; E Bowton; K Brothers; K Johnson; D C Crawford; J Schildcrout; D R Masys; H H Dilks; R A Wilke; E W Clayton; E Shultz; M Laposata; J McPherson; J N Jirjis; D M Roden
Journal:  Clin Pharmacol Ther       Date:  2012-05-16       Impact factor: 6.875

9.  "What does it mean?": uncertainties in understanding results of chromosomal microarray testing.

Authors:  Marian Reiff; Barbara A Bernhardt; Surabhi Mulchandani; Danielle Soucier; Diana Cornell; Reed E Pyeritz; Nancy B Spinner
Journal:  Genet Med       Date:  2012-01-05       Impact factor: 8.822

Review 10.  Implementing genomic medicine in the clinic: the future is here.

Authors:  Teri A Manolio; Rex L Chisholm; Brad Ozenberger; Dan M Roden; Marc S Williams; Richard Wilson; David Bick; Erwin P Bottinger; Murray H Brilliant; Charis Eng; Kelly A Frazer; Bruce Korf; David H Ledbetter; James R Lupski; Clay Marsh; David Mrazek; Michael F Murray; Peter H O'Donnell; Daniel J Rader; Mary V Relling; Alan R Shuldiner; David Valle; Richard Weinshilboum; Eric D Green; Geoffrey S Ginsburg
Journal:  Genet Med       Date:  2013-01-10       Impact factor: 8.822

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  12 in total

1.  Pharmacy students' attitudes and perceptions toward pharmacogenomics education.

Authors:  Shanice Coriolan; Nimota Arikawe; Arden Moscati; Lisheng Zhou; Stephanie Dym; Seda Donmez; Adinoyi Garba; Sasha Falbaum; Zvi Loewy; Melinda Lull; Maha Saad; Jane Shtaynberg; Aniwaa Owusu Obeng
Journal:  Am J Health Syst Pharm       Date:  2019-05-17       Impact factor: 2.637

2.  Healthcare provider education to support integration of pharmacogenomics in practice: the eMERGE Network experience.

Authors:  Carolyn R Rohrer Vitek; Noura S Abul-Husn; John J Connolly; Andrea L Hartzler; Terrie Kitchner; Josh F Peterson; Luke V Rasmussen; Maureen E Smith; Sarah Stallings; Marc S Williams; Wendy A Wolf; Cynthia A Prows
Journal:  Pharmacogenomics       Date:  2017-06-22       Impact factor: 2.533

Review 3.  Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward.

Authors:  Kelly E Caudle; Nicholas J Keeling; Teri E Klein; Michelle Whirl-Carrillo; Victoria M Pratt; James M Hoffman
Journal:  Pharmacogenomics       Date:  2018-06-19       Impact factor: 2.533

4.  Integrating Genomics into Healthcare: A Global Responsibility.

Authors:  Zornitza Stark; Lena Dolman; Teri A Manolio; Brad Ozenberger; Sue L Hill; Mark J Caulfied; Yves Levy; David Glazer; Julia Wilson; Mark Lawler; Tiffany Boughtwood; Jeffrey Braithwaite; Peter Goodhand; Ewan Birney; Kathryn N North
Journal:  Am J Hum Genet       Date:  2019-01-03       Impact factor: 11.025

5.  Sync for Genes: Making Clinical Genomics Available for Precision Medicine at the Point-of-Care.

Authors:  Stephanie J Garcia; Teresa Zayas-Cabán; Robert R Freimuth
Journal:  Appl Clin Inform       Date:  2020-04-22       Impact factor: 2.342

6.  The Implementation Chasm Hindering Genome-informed Health Care.

Authors:  Kevin B Johnson; Ellen Wright Clayton; Justin Starren; Josh Peterson
Journal:  J Law Med Ethics       Date:  2020-03       Impact factor: 1.718

Review 7.  Opportunities, resources, and techniques for implementing genomics in clinical care.

Authors:  Teri A Manolio; Robb Rowley; Marc S Williams; Dan Roden; Geoffrey S Ginsburg; Carol Bult; Rex L Chisholm; Patricia A Deverka; Howard L McLeod; George A Mensah; Mary V Relling; Laura Lyman Rodriguez; Cecelia Tamburro; Eric D Green
Journal:  Lancet       Date:  2019-08-05       Impact factor: 79.321

8.  Clinical pharmacogenomics: patient perspectives of pharmacogenomic testing and the incidence of actionable test results in a chronic disease cohort.

Authors:  Chandrama Mukherjee; Kevin M Sweet; Jasmine A Luzum; Mahmoud Abdel-Rasoul; Michael F Christman; Joseph P Kitzmiller
Journal:  Per Med       Date:  2017-09-01       Impact factor: 2.512

9.  Infobuttons for Genomic Medicine: Requirements and Barriers.

Authors:  Luke V Rasmussen; John J Connolly; Guilherme Del Fiol; Robert R Freimuth; Douglas B Pet; Josh F Peterson; Brian H Shirts; Justin B Starren; Marc S Williams; Nephi Walton; Casey Overby Taylor
Journal:  Appl Clin Inform       Date:  2021-05-12       Impact factor: 2.342

10.  Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey.

Authors:  Aniwaa Owusu Obeng; Kezhen Fei; Kenneth D Levy; Amanda R Elsey; Toni I Pollin; Andrea H Ramirez; Kristin W Weitzel; Carol R Horowitz
Journal:  J Pers Med       Date:  2018-07-24
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