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Literature DB >> 21307933

Charting a course for genomic medicine from base pairs to bedside.

Abstract

There has been much progress in genomics in the ten years since a draft sequence of the human genome was published. Opportunities for understanding health and disease are now unprecedented, as advances in genomics are harnessed to obtain robust foundational knowledge about the structure and function of the human genome and about the genetic contributions to human health and disease. Here we articulate a 2011 vision for the future of genomics research and describe the path towards an era of genomic medicine.

Entities: Species

Mesh：

Year: 2011 PMID： 21307933 DOI： 10.1038/nature09764

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

102 in total

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Journal: Nature Date: 2003-04-14 Impact factor: 49.962

2. Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.

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Journal: Clin Chem Date: 2007-09-21 Impact factor: 8.327

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5. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project.

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Journal: Science Date: 2010-12-22 Impact factor: 47.728

6. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations.

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7. Angiotensin II blockade and aortic-root dilation in Marfan's syndrome.

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Journal: N Engl J Med Date: 2008-06-26 Impact factor: 91.245

Review 8. Linking somatic genetic alterations in cancer to therapeutics.

Authors: Darrin Stuart; William R Sellers
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9. The case for a US prospective cohort study of genes and environment.

Authors: Francis S Collins
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Review 10. Microfluidics in macro-biomolecules analysis: macro inside in a nano world.

Authors: Iuliana Oita; Hadewych Halewyck; Bert Thys; Bart Rombaut; Yvan Vander Heyden; Debby Mangelings
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383 in total

1. Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study.

Authors: A E Justice; G Chittoor; E Blanco; M Graff; Y Wang; C Albala; J L Santos; B Angel; B Lozoff; V S Voruganti; K E North; S Gahagan
Journal: Pediatr Obes Date: 2018-12-04 Impact factor: 4.000

2. Next generation analytic tools for large scale genetic epidemiology studies of complex diseases.

Authors: Leah E Mechanic; Huann-Sheng Chen; Christopher I Amos; Nilanjan Chatterjee; Nancy J Cox; Rao L Divi; Ruzong Fan; Emily L Harris; Kevin Jacobs; Peter Kraft; Suzanne M Leal; Kimberly McAllister; Jason H Moore; Dina N Paltoo; Michael A Province; Erin M Ramos; Marylyn D Ritchie; Kathryn Roeder; Daniel J Schaid; Matthew Stephens; Duncan C Thomas; Clarice R Weinberg; John S Witte; Shunpu Zhang; Sebastian Zöllner; Eric J Feuer; Elizabeth M Gillanders
Journal: Genet Epidemiol Date: 2011-12-06 Impact factor: 2.135

3. A role for fibrocytes in peritoneal fibrosis?

Authors: Timothy Bowen
Journal: Perit Dial Int Date: 2012 Jan-Feb Impact factor: 1.756

4. Disclosing pathogenic genetic variants to research participants: quantifying an emerging ethical responsibility.

Authors: Christopher A Cassa; Sarah K Savage; Patrick L Taylor; Robert C Green; Amy L McGuire; Kenneth D Mandl
Journal: Genome Res Date: 2012-01-06 Impact factor: 9.043

5. Considerations in the construction of an instrument to assess attitudes regarding critical illness gene variation research.

Authors: Bradley D Freeman; Carie R Kennedy; Dragana Bolcic-Jankovic; Alexander Eastman; Ellen Iverson; Erica Shehane; Aaron Celious; Jennifer Barillas; Brian Clarridge
Journal: J Empir Res Hum Res Ethics Date: 2012-02 Impact factor: 1.742

6. BioQ: tracing experimental origins in public genomic databases using a novel data provenance model.

Authors: Scott F Saccone; Jiaxi Quan; Peter L Jones
Journal: Bioinformatics Date: 2012-03-16 Impact factor: 6.937

7. PRECISION MEDICINE: FROM DIPLOTYPES TO DISPARITIES TOWARDS IMPROVED HEALTH AND THERAPIES.

Authors: Dana C Crawford; Alexander A Morgan; Joshua C Denny; Bruce J Aronow; Steven E Brenner
Journal: Pac Symp Biocomput Date: 2018

8. Rapid whole-genome sequencing for genetic disease diagnosis in neonatal intensive care units.

Authors: Carol Jean Saunders; Neil Andrew Miller; Sarah Elizabeth Soden; Darrell Lee Dinwiddie; Aaron Noll; Noor Abu Alnadi; Nevene Andraws; Melanie LeAnn Patterson; Lisa Ann Krivohlavek; Joel Fellis; Sean Humphray; Peter Saffrey; Zoya Kingsbury; Jacqueline Claire Weir; Jason Betley; Russell James Grocock; Elliott Harrison Margulies; Emily Gwendolyn Farrow; Michael Artman; Nicole Pauline Safina; Joshua Erin Petrikin; Kevin Peter Hall; Stephen Francis Kingsmore
Journal: Sci Transl Med Date: 2012-10-03 Impact factor: 17.956

9. Geography of Genetics and Genomics Research Funding in Africa.

Authors: Eric Coles; George A Mensah
Journal: Glob Heart Date: 2017-06

Review 10. Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine.

Authors: M Elizabeth Fini; Stephen G Schwartz; Xiaoyi Gao; Shinwu Jeong; Nitin Patel; Tatsuo Itakura; Marianne O Price; Francis W Price; Rohit Varma; W Daniel Stamer
Journal: Prog Retin Eye Res Date: 2016-09-22 Impact factor: 21.198