Literature DB >> 28639489

Healthcare provider education to support integration of pharmacogenomics in practice: the eMERGE Network experience.

Carolyn R Rohrer Vitek1, Noura S Abul-Husn2, John J Connolly3, Andrea L Hartzler4, Terrie Kitchner5, Josh F Peterson6, Luke V Rasmussen7, Maureen E Smith8, Sarah Stallings9, Marc S Williams10, Wendy A Wolf11, Cynthia A Prows12.   

Abstract

Ten organizations within the Electronic Medical Records and Genomics Network developed programs to implement pharmacogenomic sequencing and clinical decision support into clinical settings. Recognizing the importance of informed prescribers, a variety of strategies were used to incorporate provider education to support implementation. Education experiences with pharmacogenomics are described within the context of each organization's prior involvement, including the scope and scale of implementation specific to their Electronic Medical Records and Genomics projects. We describe common and distinct education strategies, provide exemplars and share challenges. Lessons learned inform future perspectives. Future pharmacogenomics clinical implementation initiatives need to include funding toward implementing provider education and evaluating outcomes.

Keywords:  clinical decision support; education; pharmacogenetics; pharmacogenomics; pre-emptive testing

Mesh:

Year:  2017        PMID: 28639489      PMCID: PMC5941709          DOI: 10.2217/pgs-2017-0038

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN: 1462-2416            Impact factor:   2.533


  46 in total

1.  Survey of genetic counselors and clinical geneticists' use and attitudes toward pharmacogenetic testing.

Authors:  S B Haga; J M O'Daniel; G M Tindall; R Mills; I M Lipkus; R Agans
Journal:  Clin Genet       Date:  2012-02-19       Impact factor: 4.438

2.  Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.

Authors:  Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde
Journal:  J Biomed Inform       Date:  2008-09-30       Impact factor: 6.317

3.  Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial).

Authors:  Iftikhar J Kullo; Hayan Jouni; Erin E Austin; Sherry-Ann Brown; Teresa M Kruisselbrink; Iyad N Isseh; Raad A Haddad; Tariq S Marroush; Khader Shameer; Janet E Olson; Ulrich Broeckel; Robert C Green; Daniel J Schaid; Victor M Montori; Kent R Bailey
Journal:  Circulation       Date:  2016-02-25       Impact factor: 29.690

4.  Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients.

Authors:  Cynthia A Prows; Todd G Nick; Shannon N Saldaña; Sanjeev Pathak; Chunyan Liu; Kejian Zhang; Zachary S Daniels; Alexander A Vinks; Tracy A Glauser
Journal:  J Child Adolesc Psychopharmacol       Date:  2009-08       Impact factor: 2.576

Review 5.  Learning and change: implications for continuing medical education.

Authors:  R D Fox; N L Bennett
Journal:  BMJ       Date:  1998-02-07

6.  Impact of formal continuing medical education: do conferences, workshops, rounds, and other traditional continuing education activities change physician behavior or health care outcomes?

Authors:  D Davis; M A O'Brien; N Freemantle; F M Wolf; P Mazmanian; A Taylor-Vaisey
Journal:  JAMA       Date:  1999-09-01       Impact factor: 56.272

7.  Primary care physicians' knowledge of and experience with pharmacogenetic testing.

Authors:  S B Haga; W Burke; G S Ginsburg; R Mills; R Agans
Journal:  Clin Genet       Date:  2012-07-03       Impact factor: 4.438

8.  Genomics nursing Faculty Champion initiative.

Authors:  Jean Jenkins; Kathleen A Calzone
Journal:  Nurse Educ       Date:  2014 Jan-Feb       Impact factor: 2.082

9.  Prospective participant selection and ranking to maximize actionable pharmacogenetic variants and discovery in the eMERGE Network.

Authors:  David R Crosslin; Peggy D Robertson; David S Carrell; Adam S Gordon; David S Hanna; Amber Burt; Stephanie M Fullerton; Aaron Scrol; James Ralston; Kathleen Leppig; Andrea Hartzler; Eric Baldwin; Mariza de Andrade; Iftikhar J Kullo; Gerard Tromp; Kimberly F Doheny; Marylyn D Ritchie; Paul K Crane; Deborah A Nickerson; Eric B Larson; Gail P Jarvik
Journal:  Genome Med       Date:  2015-07-03       Impact factor: 11.117

10.  Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems.

Authors:  L J Rasmussen-Torvik; S C Stallings; A S Gordon; B Almoguera; M A Basford; S J Bielinski; A Brautbar; M H Brilliant; D S Carrell; J J Connolly; D R Crosslin; K F Doheny; C J Gallego; O Gottesman; D S Kim; K A Leppig; R Li; S Lin; S Manzi; A R Mejia; J A Pacheco; V Pan; J Pathak; C L Perry; J F Peterson; C A Prows; J Ralston; L V Rasmussen; M D Ritchie; S Sadhasivam; S A Scott; M Smith; A Vega; A A Vinks; S Volpi; W A Wolf; E Bottinger; R L Chisholm; C G Chute; J L Haines; J B Harley; B Keating; I A Holm; I J Kullo; G P Jarvik; E B Larson; T Manolio; C A McCarty; D A Nickerson; S E Scherer; M S Williams; D M Roden; J C Denny
Journal:  Clin Pharmacol Ther       Date:  2014-06-24       Impact factor: 6.875

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  14 in total

Review 1.  Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward.

Authors:  Kelly E Caudle; Nicholas J Keeling; Teri E Klein; Michelle Whirl-Carrillo; Victoria M Pratt; James M Hoffman
Journal:  Pharmacogenomics       Date:  2018-06-19       Impact factor: 2.533

Review 2.  Physician preparedness for big genomic data: a review of genomic medicine education initiatives in the United States.

Authors:  Caryn Kseniya Rubanovich; Cynthia Cheung; Jess Mandel; Cinnamon S Bloss
Journal:  Hum Mol Genet       Date:  2018-08-01       Impact factor: 6.150

3.  Impact of SLCO1B1 Pharmacogenetic Testing on Patient and Healthcare Outcomes: A Systematic Review.

Authors:  Jason L Vassy; Sojeong Chun; Sanjay Advani; Sophie A Ludin; Jason G Smith; Elaine C Alligood
Journal:  Clin Pharmacol Ther       Date:  2018-10-18       Impact factor: 6.875

Review 4.  Personalized Medicine and the Power of Electronic Health Records.

Authors:  Noura S Abul-Husn; Eimear E Kenny
Journal:  Cell       Date:  2019-03-21       Impact factor: 41.582

5.  Barriers and Facilitators for Population Genetic Screening in Healthy Populations: A Systematic Review.

Authors:  Emily C Shen; Swetha Srinivasan; Lauren E Passero; Caitlin G Allen; Madison Dixon; Kimberly Foss; Brianna Halliburton; Laura V Milko; Amelia K Smit; Rebecca Carlson; Megan C Roberts
Journal:  Front Genet       Date:  2022-07-04       Impact factor: 4.772

6.  Integrating pharmacogenetic testing into primary care.

Authors:  Susanne B Haga
Journal:  Expert Rev Precis Med Drug Dev       Date:  2017-11-03

Review 7.  Personalized Medicine Implementation with Non-traditional Data Sources: A Conceptual Framework and Survey of the Literature.

Authors:  Casey Overby Taylor; Peter Tarczy-Hornoch
Journal:  Yearb Med Inform       Date:  2019-08-16

Review 8.  Challenges and Future Prospects of Precision Medicine in Psychiatry.

Authors:  Mirko Manchia; Claudia Pisanu; Alessio Squassina; Bernardo Carpiniello
Journal:  Pharmgenomics Pers Med       Date:  2020-04-23

9.  Genomic Information for Clinicians in the Electronic Health Record: Lessons Learned From the Clinical Genome Resource Project and the Electronic Medical Records and Genomics Network.

Authors:  Marc S Williams; Casey Overby Taylor; Nephi A Walton; Scott R Goehringer; Samuel Aronson; Robert R Freimuth; Luke V Rasmussen; Eric S Hall; Cynthia A Prows; Wendy K Chung; Alexander Fedotov; Jordan Nestor; Chunhua Weng; Robb K Rowley; Georgia L Wiesner; Gail P Jarvik; Guilherme Del Fiol
Journal:  Front Genet       Date:  2019-10-29       Impact factor: 4.599

Review 10.  Lessons learned from the eMERGE Network: balancing genomics in discovery and practice.

Authors: 
Journal:  HGG Adv       Date:  2020-12-25
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