Effects of Nasal Occlusion and Oral Contact on Perception of Metallic Taste from Metal Salts.

Iron and copper salts have complex olfactory and gustatory properties including a metallic flavor component that is decreased by nasal occlusion. To examine the sensory properties of ferrous sulfate and copper sulfate, a trained descriptive panel evaluated these compounds at equal molarity and perceived equal intensity with and without nasal occlusion. Ferrous sulfate exhibited a metallic taste and metallic aftertaste and copper sulfate exhibited a more pronounced metallic aftertaste. Metallic sensations were decreased by nasal occlusion, which in the absence of any orthonasal metallic smell, implies that the sensations were retronasally perceived volatiles in the nose open condition. Ferrous sulfate showed a larger effect of nasal occlusion. A second experiment isolated ferrous sulfate solutions from oral contact via a plastic barrier. In comparison to a condition in which oral contact was allowed, intensity ratings were decreased. This result is consistent with the hypothesis that rinses with solutions of metal salts, particularly ferrous sulfate, generate volatile lipid oxidation products in the mouth that are perceived retronasally as metallic flavors.