Christopher Nguyen1, Zhaoyang Fan1, Yibin Xie1, Jianing Pang1, Peter Speier2, Xiaoming Bi3, Jon Kobashigawa4, Debiao Li5,6. 1. Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. 2. Siemens Healthcare GmbH, Erlangen, Germany. 3. Siemens Healthcare, Los Angeles, California, USA. 4. Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. 5. Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. debiao.li@cshs.org. 6. Department of Bioengineering, University of California Los Angeles, Los Angeles, California, USA. debiao.li@cshs.org.
Abstract
PURPOSE: To optimize a diffusion-prepared balanced steady-state free precession cardiac MRI (CMR) technique to perform diffusion-tensor CMR (DT-CMR) in humans on a 3 Tesla clinical scanner METHODS: A previously developed second order motion compensated (M2) diffusion-preparation scheme was significantly shortened (40%) yielding sufficient signal-to-noise ratio for DT-CMR imaging. In 20 healthy volunteers and 3 heart failure (HF) patients, DT-CMR was performed comparing no motion compensation (M0), first order motion compensation (M1), and the optimized M2. Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and HA transmural slope (HATS) were calculated. Reproducibility and success rate (SR) were investigated. RESULTS: M2-derived left ventricular (LV) MD, FA, and HATS (1.4 ± 0.2 μm2 /ms, 0.28 ± 0.06, -1.0 ± 0.2 °/%trans) were significantly (P < 0.001) less than M1 (1.8 ± 0.3 μm2 /ms, 0.46 ± 0.14, -0.1 ± 0.3 °/%trans) and M0 (4.8 ± 1.0 μm2 /ms, 0.70 ± 0.14, 0.1 ± 0.3 °/%trans) indicating less motion corruption and yielding values more consistent with previous literature. M2-derived DT-CMR parameters had higher reproducible (ICC > 0.85) and SR (82%) than M1 (ICC = 0.20-0.85; SR = 37%) and M0 (ICC = 0.20-0.30; SR = 11%). M2 DT-CMR was able to yield HA maps with smooth transmural transition from endocardium to epicardium. CONCLUSION: The proposed M2 DT-CMR reproducibly yielded bulk motion robust estimations of mean LV MD, FA, HA, and HATS on a 3T clinical scanner. Magn Reson Med 76:1354-1363, 2016.
PURPOSE: To optimize a diffusion-prepared balanced steady-state free precession cardiac MRI (CMR) technique to perform diffusion-tensor CMR (DT-CMR) in humans on a 3 Tesla clinical scanner METHODS: A previously developed second order motion compensated (M2) diffusion-preparation scheme was significantly shortened (40%) yielding sufficient signal-to-noise ratio for DT-CMR imaging. In 20 healthy volunteers and 3 heart failure (HF) patients, DT-CMR was performed comparing no motion compensation (M0), first order motion compensation (M1), and the optimized M2. Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and HA transmural slope (HATS) were calculated. Reproducibility and success rate (SR) were investigated. RESULTS: M2-derived left ventricular (LV) MD, FA, and HATS (1.4 ± 0.2 μm2 /ms, 0.28 ± 0.06, -1.0 ± 0.2 °/%trans) were significantly (P < 0.001) less than M1 (1.8 ± 0.3 μm2 /ms, 0.46 ± 0.14, -0.1 ± 0.3 °/%trans) and M0 (4.8 ± 1.0 μm2 /ms, 0.70 ± 0.14, 0.1 ± 0.3 °/%trans) indicating less motion corruption and yielding values more consistent with previous literature. M2-derived DT-CMR parameters had higher reproducible (ICC > 0.85) and SR (82%) than M1 (ICC = 0.20-0.85; SR = 37%) and M0 (ICC = 0.20-0.30; SR = 11%). M2 DT-CMR was able to yield HA maps with smooth transmural transition from endocardium to epicardium. CONCLUSION: The proposed M2 DT-CMR reproducibly yielded bulk motion robust estimations of mean LV MD, FA, HA, and HATS on a 3T clinical scanner. Magn Reson Med 76:1354-1363, 2016.
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