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Literature DB >> 27450436

Regulation of Single-Strand Annealing and its Role in Genome Maintenance.

Ragini Bhargava¹, David O Onyango², Jeremy M Stark³.

Abstract

Single-strand annealing (SSA) is a DNA double-strand break (DSB) repair pathway that uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single DSB causes a deletion rearrangement between the repeats, and hence is relatively mutagenic. Nevertheless, this pathway is conserved, in that SSA events have been found in several organisms. In this review, we describe the mechanism of SSA and its regulation, including the cellular conditions that may favor SSA versus other DSB repair events. We will also evaluate the potential contribution of SSA to cancer-associated genome rearrangements, and to DSB-induced gene targeting.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: RAD51; RAD52; alternative end joining; end resection; homology directed repair; single-strand annealing

Mesh：

Substances：
DNA-Binding Proteins

Year: 2016 PMID： 27450436 PMCID： PMC4992407 DOI： 10.1016/j.tig.2016.06.007

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

110 in total

1. Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.

Authors: Anabelle Decottignies
Journal: Genetics Date: 2007-05-04 Impact factor: 4.562

2. Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process.

Authors: F L Lin; K Sperle; N Sternberg
Journal: Mol Cell Biol Date: 1984-06 Impact factor: 4.272

3. Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing.

Authors: Francesca Storici; Joyce R Snipe; Godwin K Chan; Dmitry A Gordenin; Michael A Resnick
Journal: Mol Cell Biol Date: 2006-08-14 Impact factor: 4.272

4. Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes.

Authors: Eli Rothenberg; Jill M Grimme; Maria Spies; Taekjip Ha
Journal: Proc Natl Acad Sci U S A Date: 2008-12-11 Impact factor: 11.205

Regulation of Single-Strand Annealing and its Role in Genome Maintenance.

1. Microhomology-mediated end joining in fission yeast is repressed by pku70 and relies on genes involved in homologous recombination.

2. Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process.

3. Conservative repair of a chromosomal double-strand break by single-strand DNA through two steps of annealing.

4. Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes.

5. MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems.

6. Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase.

7. Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ.

8. DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.

9. Limiting the persistence of a chromosome break diminishes its mutagenic potential.

10. The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends.

1. DNA Damage Repair Inhibitor for Breast Cancer Treatment.

2. Genome plasticity in Candida albicans is driven by long repeat sequences.

3. Stitching up broken DNA ends by FANCA.

Review 4. Ways of improving precise knock-in by genome-editing technologies.

5. Meiotic Double-Strand Break Proteins Influence Repair Pathway Utilization.

Review 6. Microhomology-mediated end joining: Good, bad and ugly.

Review 7. The molecular basis and disease relevance of non-homologous DNA end joining.

Review 8. Non-homologous DNA end joining and alternative pathways to double-strand break repair.

Review 9. Clinically Applicable Inhibitors Impacting Genome Stability.

10. Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling.