Literature DB >> 30525096

Stitching up broken DNA ends by FANCA.

Anna Palovcak1, Wenjun Liu1, Fenghua Yuan1, Yanbin Zhang1.   

Abstract

RAD52 rejoins resected broken DNA ends by mediating single-strand annealing. Our recent work elucidates that FANCA, a Fanconi anemia protein, also directly repairs double-strand breaks (DSBs) by catalyzing annealing of single-stranded DNA. FANCA and RAD52 likely play complementary roles to each other to prevent deleterious consequences of DSBs. Abbreviations: DSBs: DNA double-strand breaks; ICL: interstrand crosslink; ssDNA: single-stranded DNA; HR: homologous recombination; SSA: single-strand annealing; MMEJ: microhomology-mediated end joining; NHEJ: non-homologous end joining; GFP: green fluorescence protein.

Entities:  

Keywords:  FANCA; Fanconi anemia; double strand break repair; interstrand crosslink repair

Year:  2018        PMID： 30525096      PMCID： PMC6276842          DOI： 10.1080/23723556.2018.1518101

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Authors:  Wendy J Cannan; David S Pederson
Journal:  J Cell Physiol       Date:  2016-01       Impact factor: 6.384

2.  Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.

Authors:  Koji Nakanishi; Yun-Gui Yang; Andrew J Pierce; Toshiyasu Taniguchi; Martin Digweed; Alan D D'Andrea; Zhao-Qi Wang; Maria Jasin
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-13       Impact factor: 11.205

Review 3.  How cells ensure correct repair of DNA double-strand breaks.

Authors:  Joonyoung Her; Samuel F Bunting
Journal:  J Biol Chem       Date:  2018-02-05       Impact factor: 5.157

4.  FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange.

Authors:  Anaid Benitez; Wenjun Liu; Anna Palovcak; Guanying Wang; Jaewon Moon; Kevin An; Anna Kim; Kevin Zheng; Yu Zhang; Feng Bai; Alexander V Mazin; Xin-Hai Pei; Fenghua Yuan; Yanbin Zhang
Journal:  Mol Cell       Date:  2018-07-26       Impact factor: 17.970

Review 5.  Regulation of Single-Strand Annealing and its Role in Genome Maintenance.

Authors:  Ragini Bhargava; David O Onyango; Jeremy M Stark
Journal:  Trends Genet       Date:  2016-07-19       Impact factor: 11.639

6.  BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair.

Authors:  Margret S Fernandes; Mamatha M Reddy; Jeffrey R Gonneville; Scott C DeRoo; Klaus Podar; James D Griffin; David M Weinstock; Martin Sattler
Journal:  Blood       Date:  2009-07-01       Impact factor: 22.113

Review 7.  DNA end resection: many nucleases make light work.

Authors:  Eleni P Mimitou; Lorraine S Symington
Journal:  DNA Repair (Amst)       Date:  2009-05-26

8.  Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

Authors:  Linn Fagerberg; Björn M Hallström; Per Oksvold; Caroline Kampf; Dijana Djureinovic; Jacob Odeberg; Masato Habuka; Simin Tahmasebpoor; Angelika Danielsson; Karolina Edlund; Anna Asplund; Evelina Sjöstedt; Emma Lundberg; Cristina Al-Khalili Szigyarto; Marie Skogs; Jenny Ottosson Takanen; Holger Berling; Hanna Tegel; Jan Mulder; Peter Nilsson; Jochen M Schwenk; Cecilia Lindskog; Frida Danielsson; Adil Mardinoglu; Asa Sivertsson; Kalle von Feilitzen; Mattias Forsberg; Martin Zwahlen; IngMarie Olsson; Sanjay Navani; Mikael Huss; Jens Nielsen; Fredrik Ponten; Mathias Uhlén
Journal:  Mol Cell Proteomics       Date:  2013-12-05       Impact factor: 5.911

9.  Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors.

Authors:  Fei Huang; Nadish Goyal; Katherine Sullivan; Kritika Hanamshet; Mikir Patel; Olga M Mazina; Charles X Wang; W Frank An; James Spoonamore; Shailesh Metkar; Kyle A Emmitte; Simon Cocklin; Tomasz Skorski; Alexander V Mazin
Journal:  Nucleic Acids Res       Date:  2016-02-11       Impact factor: 16.971

10.  Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance.

Authors:  Rachel W Anantha; Srilatha Simhadri; Tzeh Keong Foo; Susanna Miao; Jingmei Liu; Zhiyuan Shen; Shridar Ganesan; Bing Xia
Journal:  Elife       Date:  2017-04-11       Impact factor: 8.140
  10 in total
  2 in total

Review 1.  Fanconi anemia pathway as a prospective target for cancer intervention.

Authors:  Wenjun Liu; Anna Palovcak; Fang Li; Alyan Zafar; Fenghua Yuan; Yanbin Zhang
Journal:  Cell Biosci       Date:  2020-03-16       Impact factor: 7.133

2.  DNA double-strand break repair gene mutation and the risk of papillary thyroid microcarcinoma: a case-control study.

Authors:  Jiali Qin; Jie Fan; Shanting Liu; Zhensheng Liu; Gang Li; Yao Wu
Journal:  Cancer Cell Int       Date:  2021-07-02       Impact factor: 5.722
  2 in total

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