| Literature DB >> 27399966 |
David L Morris1, Yujun Sheng2,3,4, Yan Zhang5, Timothy J Vyse1,6, Yong-Fei Wang5, Zhengwei Zhu2,3, Philip Tombleson1, Lingyan Chen1, Deborah S Cunninghame Graham1, James Bentham7, Amy L Roberts1, Ruoyan Chen5, Xianbo Zuo2,3, Tingyou Wang5, Leilei Wen2,3, Chao Yang2,3, Lu Liu2,3, Lulu Yang2,3, Feng Li2,3, Yuanbo Huang2,3, Xianyong Yin2,3, Sen Yang2,3, Lars Rönnblom8, Barbara G Fürnrohr9,10,11,12, Reinhard E Voll9,10,13,14,15, Georg Schett9,10, Nathalie Costedoat-Chalumeau16,17, Patrick M Gaffney18, Yu Lung Lau5,19, Xuejun Zhang2,3,20, Wanling Yang5, Yong Cui2,3,4.
Abstract
Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune disease. Genome-wide association studies (GWASs) have identified more than 50 loci as robustly associated with the disease in single ancestries, but genome-wide transancestral studies have not been conducted. We combined three GWAS data sets from Chinese (1,659 cases and 3,398 controls) and European (4,036 cases and 6,959 controls) populations. A meta-analysis of these studies showed that over half of the published SLE genetic associations are present in both populations. A replication study in Chinese (3,043 cases and 5,074 controls) and European (2,643 cases and 9,032 controls) subjects found ten previously unreported SLE loci. Our study provides further evidence that the majority of genetic risk polymorphisms for SLE are contained within the same regions across both populations. Furthermore, a comparison of risk allele frequencies and genetic risk scores suggested that the increased prevalence of SLE in non-Europeans (including Asians) has a genetic basis.Entities:
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Year: 2016 PMID： 27399966 PMCID： PMC4966635 DOI： 10.1038/ng.3603
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330